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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 567.88 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 359.00 °F. TCC ( 181.90 °C. ) (est)
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| logP (o/w): | 3.459 (est) |
| Soluble in: |
| | water, 1.019 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for herboxidiene usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for herboxidiene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6438496 |
| National Institute of Allergy and Infectious Diseases:Data |
| 2-[(2R,5S,6S)-6-[(2E,4E,6S)-7-[(2R,3R)-3-[(2R,3R,4R)-4-hydroxy-3-methoxypentan-2-yl]-2-methyloxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-5-methyloxan-2-yl]acetic acid |
| Chemidplus:0142861005 |
References:
| | 2-[(2R,5S,6S)-6-[(2E,4E,6S)-7-[(2R,3R)-3-[(2R,3R,4R)-4-hydroxy-3-methoxypentan-2-yl]-2-methyloxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-5-methyloxan-2-yl]acetic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6438496 |
| Pubchem (sid): | 135080559 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2-[(2R,5S,6S)-6-[(2E,4E,6S)-7-[(2R,3R)-3-[(2R,3R,4R)-4- | hydroxy-3-methoxypentan-2-yl]-2-methyloxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-5-methyloxan-2-yl]acetic acid | | 2H- | pyran-2-acetic acid, tetrahydro-6-(6-(3-(3-hydroxy-2-methoxy-1-methylbutyl)-2-methyloxiranyl)-1,5-dimethyl-1,3-hexadienyl)-5-methyl- |
Articles:
| PubMed:A specific cytochrome P450 hydroxylase in herboxidiene biosynthesis. |
| PubMed:Switching Antibiotics Production On and Off in Actinomycetes by an IclR Family Transcriptional Regulator from Streptomyces peucetius ATCC 27952. |
| PubMed:Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives. |
| PubMed:Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs. |
| PubMed:Enhancement of herboxidiene production in Streptomyces chromofuscus ATCC 49982. |
| PubMed:Characterization of a methyltransferase involved in herboxidiene biosynthesis. |
| PubMed:Comparison of splicing factor 3b inhibitors in human cells. |
| PubMed:Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982. |
| PubMed:Total synthesis of (+)-herboxidiene from two chiral lactate-derived ketones. |
| PubMed:Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product. |
| PubMed:A stereoselective synthesis of (+)-herboxidiene/GEX1A. |
| PubMed:Total synthesis of GEX1A. |
| PubMed:Total synthesis of herboxidiene/GEX 1A. |
| PubMed:GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression. |
| PubMed:GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities. |
| PubMed:Synthesis of simplified herboxidiene aromatic hybrids. |
| PubMed:Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor. |
| PubMed:Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties. |
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3D/inchi