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Category:food additive
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 872.63 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 585.00 °F. TCC ( 307.50 °C. ) (est)
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| logP (o/w): | -0.111 (est) |
| Soluble in: |
| | water, 2.782e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | food additive |
| Recommendation for hyperoside usage levels up to: | | | not for fragrance use.
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| Recommendation for hyperoside flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5281643 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| Chemidplus:0000482360 |
| RTECS:DJ3009200 for cas# 482-36-0 |
References:
| | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5281643 |
| Pubchem (sid): | 135030293 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(b-D-galactopyranosyloxy)-5,7-dihydroxy- | | 2-(3,4- | dihydroxyphenyl)-3-(beta-dextro-galactopyranosyl oxy)-5,7-dihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | | 2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl b-D-galactopyranoside | | | hydroside | | | hyperasid | | | hyperin | | | hyperosid | | | hyperozide | | | quercetin 3-b-D-galactopyranoside | | | quercetin 3-D-galactoside | | | quercetin 3-O-b-D-galactopyranoside | | | quercetin-3-D-galactoside |
Articles:
| PubMed:Modeling of the total antioxidant capacity of rooibos (Aspalathus linearis) tea infusions from chromatographic fingerprints and identification of potential antioxidant markers. |
| PubMed:Purification and characterization of flavonoids from the leaves of Zanthoxylum bungeanum and correlation between their structure and antioxidant activity. |
| PubMed:Phytochemical profiles and antioxidant and antimicrobial activities of the leaves of Zanthoxylum bungeanum. |
| PubMed:Ionic liquid-based one-step micellar extraction of multiclass polar compounds from hawthorn fruits by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. |
| PubMed:Flavonol glycosides and other phenolic compounds in buds and leaves of different varieties of black currant (Ribes nigrum L.) and changes during growing season. |
| PubMed:Hyperoside and anthocyanin content of ten different pomegranate cultivars. |
| PubMed:Quantification of individual phenolic compounds' contribution to antioxidant capacity in apple: a novel analytical tool based on liquid chromatography with diode array, electrochemical, and charged aerosol detection. |
| PubMed:Hyperoside downregulates the receptor for advanced glycation end products (RAGE) and promotes proliferation in ECV304 cells via the c-Jun N-terminal kinases (JNK) pathway following stimulation by advanced glycation end-products in vitro. |
| PubMed:Comparative analysis of Tunisian wild Crataegus azarolus (yellow azarole) and Crataegus monogyna (red azarole) leaf, fruit, and traditionally derived syrup: phenolic profiles and antioxidant and antimicrobial activities of the aqueous-acetone extracts. |
| PubMed:Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6. |
| PubMed:Determination of hyperin in seed of Cuscuta chinensis Lam. by enhanced chemiluminescence of CdTe quantum dots on calcein/K3Fe(CN)6 system. |
| PubMed:Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris. |
| PubMed:Polyphenolics composition of the leaves of Zanthoxylum bungeanum Maxim. grown in Hebei, China, and their radical scavenging activities. |
| PubMed:Development of a validated HPLC method for the simultaneous determination of flavonoids in Cuscuta chinensis Lam. by ultra-violet detection. |
| PubMed:Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Receptaculum Nelumbinis by RP-HPLC Coupled with Hierarchical Clustering Analysis. |
| PubMed:Antithrombotic and profibrinolytic activities of isorhamnetin-3-O-galactoside and hyperoside. |
| PubMed:Variation in phenolic content and antioxidant activity of fermented rooibos herbal tea infusions: role of production season and quality grade. |
| PubMed:Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. |
| PubMed:Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats. |
| PubMed:Assessment of flavonoids contents and in vitro antioxidant activity of Launaea procumbens. |
| PubMed:A review of the chemistry of the genus Crataegus. |
| PubMed:Chemical composition and hepatoprotective effects of polyphenol-rich extract from Houttuynia cordata tea. |
| PubMed:Between species diversity of Hypericum perforatum and H. maculatum by the content of bioactive compounds. |
| PubMed:Pretreatment with the total flavone glycosides of Flos Abelmoschus manihot and hyperoside prevents glomerular podocyte apoptosis in streptozotocin-induced diabetic nephropathy. |
| PubMed:Phenolic composition in different genotypes of Guabiju fruits (Myrcianthes pungens) and their potential as antioxidant and antichemotactic agents. |
| PubMed:Comparative analysis of the chemical composition and antioxidant activity of red (Psidium cattleianum) and yellow (Psidium cattleianum var. lucidum) strawberry guava fruit. |
| PubMed:Phenolic compounds in hawthorn (Crataegus grayana) fruits and leaves and changes during fruit ripening. |
| PubMed:Quantitative analysis of phenolic compounds in Chinese hawthorn (Crataegus spp.) fruits by high performance liquid chromatography-electrospray ionisation mass spectrometry. |
| PubMed:Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat. |
| PubMed:Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki. |
| PubMed:Edible neotropical blueberries: antioxidant and compositional fingerprint analysis. |
| PubMed:Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. |
| PubMed:Consumption of polyphenol concentrate with dietary fructo-oligosaccharides enhances cecal metabolism of quercetin glycosides in rats. |
| PubMed:Highly variable contents of phenolics in St. John's Wort products affect their transport in the human intestinal Caco-2 cell model: pharmaceutical and biopharmaceutical rationale for product standardization. |
| PubMed:Synergetic effect and structure-activity relationship of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors from Crataegus pinnatifida Bge. |
| PubMed:Isolation and purification of three flavonoid glycosides from the leaves of Nelumbo nucifera (Lotus) by high-speed counter-current chromatography. |
| PubMed:Protective effects of leaf extract of Zanthoxylum ailanthoides on oxidation of low-density lipoprotein and accumulation of lipid in differentiated THP-1 cells. |
| PubMed:Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. |
| PubMed:Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines. |
| PubMed:Effect of Albizia julibrissin water extracts on low-density lipoprotein oxidization. |
| PubMed:Phenolic compounds, organic acids profiles and antioxidative properties of beefsteak fungus (Fistulina hepatica). |
| PubMed:Quantification of the polyphenols and triterpene acids in chinese hawthorn fruit by high-performance liquid chromatography. |
| PubMed:Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L. |
| PubMed:Approach to novel functional foods for stress control 5. Antioxidant activity profiles of antidepressant herbs and their active components. |
| PubMed:An improved method for the quantitation of flavonoids in Herba Leonuri by capillary electrophoresis. |
| PubMed:Inhibitors of the epidermal growth factor receptor in apple juice extract. |
| PubMed:Herbal drug quality and phytochemical composition of Hypericum perforatum L. affected by ash yellows phytoplasma infection. |
| PubMed:Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata. |
| PubMed:Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro. |
| PubMed:The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. |
| PubMed:Unfermented rooibos tea: quantitative characterization of flavonoids by HPLC-UV and determination of the total antioxidant activity. |
| PubMed:Antioxidant capacity of polyphenolic extracts from leaves of Crataegus laevigata and Crataegus monogyna (Hawthorn) subjected to drought and cold stress. |
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Occurs widely in plants, e.g. in apple peel and Hypericum perforatum (St John's wort)
Hyperoside is the 3-O-galactoside of quercetin. It is a medicinally active compound that can be isolated from Drosera rotundifolia, from the Stachys plant, from Prunella vulgaris, from Rumex acetosella and from St John's wort. (Wikipedia)
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3D/inchi