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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellow to brown powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 374.00 to 375.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.000001 mmHg @ 25.00 °C. (est) |
| Flash Point: | 525.00 °F. TCC ( 273.89 °C. )
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| logP (o/w): | 5.188 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: |
| | alcohol | | | water, slightly | | | water, 3.284 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for valerenic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for valerenic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (E)-3-[(4S,7R,7aR)-3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6440940 |
| Pubchem (sid): | 135115560 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2E)-3-[(4S,7R,7aR)-3,7- | dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylacrylic acid | | (2E)-3-[(4S,7R,7aR)-3,7- | dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid | | (E)-3-[(4S,7R,7aR)-3,7- | dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid | | (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a- | hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid | | (4S-(4alpha(E),7beta,7aalpha))-3-(2,4,5,6,7,7a- | hexahydro-3,7-dimethyl-1H-inden-4-yl)-2-methyl-2-propenoic acid | | 2- | propenoic acid, 3-[(4S,7R,7aR)-2,4,5,6,7,7a-hexahydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-, (2E)- | | | valerenicacid | | | valerinic acid |
Articles:
| PubMed:Esters of valerenic acid as potential prodrugs. |
| PubMed:Revised structures of nardal and nardin: identity with valerenal and valerenic acid. |
| PubMed:Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. |
| PubMed:Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansii in comparison to Valeriana officinalis. |
| PubMed:Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. |
| PubMed:Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity. |
| PubMed:Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors. |
| PubMed:Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). |
| PubMed:Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations. |
| PubMed:Efficient and scalable one-pot synthesis of 2,4-dienols from cycloalkenones: optimized total synthesis of valerenic acid. |
| PubMed:Three phases hollow fiber LPME combined with HPLC-UV for extraction, preconcentration and determination of valerenic acid in Valeriana officinalis. |
| PubMed:Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes. |
| PubMed:Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice. |
| PubMed:Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women. |
| PubMed:Concise synthesis of Valerena-4,7(11)-diene, a highly active sedative, from valerenic acid. |
| PubMed:Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. |
| PubMed:Highly potent modulation of GABA(A) receptors by valerenic acid derivatives. |
| PubMed:Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. |
| PubMed:Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L. |
| PubMed:Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle. |
| PubMed:Total synthesis of valerenic acid, a potent GABAA receptor modulator. |
| PubMed:Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: role of Mrp2 (Abcc2). |
| PubMed:Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier. |
| PubMed:GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. |
| PubMed:HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes. |
| PubMed:[Studies on chemical constituents of Valeriana officinalis]. |
| PubMed:Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation. |
| PubMed:Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. |
| PubMed:[GC-MS analysis of volatile constituents from five different kinds of Chinese eaglewood]. |
| PubMed:Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity. |
| PubMed:Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro. |
| PubMed:NF-kappaB modulators from Valeriana officinalis. |
| PubMed:Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes. |
| PubMed:Chemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. |
| PubMed:Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. |
| PubMed:Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. |
| PubMed:Extraction of valerenic acids from valerian (Valeriana officinalis L.) rhizomes. |
| PubMed:In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. |
| PubMed:Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. |
| PubMed:Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. |
| PubMed:Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. |
| PubMed:Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. |
| PubMed:The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. |
| PubMed:In vitro release of valerenic and hydroxyvalerenic acids from valerian tablets. |
| PubMed:(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis. |
| PubMed:Valepotriates and valerenic acids in commercial preparations of valerian available in Australia. |
| PubMed:Analysis of sesquiterpenes in Valeriana officinalis by capillary electrophoresis. |
| PubMed:Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia. |
| PubMed:Valerenic acid derivatives and valepotriates among individuals, varieties and species of Valeriana. |
| PubMed:The scientific basis for the reputed activity of Valerian. |
| PubMed:Cytotoxic potential of valerian constituents and valerian tinctures. |
| PubMed:Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines. |
| PubMed:In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. |
| PubMed:Central nervous depressant activity of valerenic Acid in the mouse. |
| PubMed:Central nervous depressant activity of valerenic acid in the mouse. |
| PubMed:[Inhibition of gamma-aminobutyric acid catabolism by valerenic acid derivatives]. |
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3D/inchi