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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 500.00 to 501.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 366.00 °F. TCC ( 185.80 °C. ) (est)
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| logP (o/w): | 4.206 (est) |
| Soluble in: |
| | water, 17.57 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Flavokawain B 98%
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| BOC Sciences |
| For experimental / research use only. |
| Flavokawain B 98%
Odor: characteristic Use: Flavokawain B is a chalcone isolated from Piper methysticum with strong antiangiogenic activity. |
| Coompo |
| For experimental / research use only. |
| Flavokawain B from Plants ≥98%
Odor: characteristic Use: Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-?B and MAPK signaling pathways.
Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
A potent anti-inflammatory. Flavokawain B significantly inhibited production of NO and PGE2 in LPS-induced RAW 264.7 cells.
Robust mechanisms for Flavokawain B induction of apoptosis preferentially for hormone-refractory prostate cancer and the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. |
| ExtraSynthese |
| For experimental / research use only. |
| Flavokawain B
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Flavokawain B
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Safety Information:
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for flavokawain B usage levels up to: | | | not for fragrance use.
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| Recommendation for flavokawain B flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5356121 |
| Pubchem (sid): | 135269659 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2',4'- | dimethoxy-6'-hydroxychalcone | | (E)-1-(2- | hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-propenone | | (E)-1-(2- | hydroxy-4,6-dimethoxy-phenyl)-3-phenylpropenone | | (E)-1-(2- | hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one | | (2E)-1-(2- | hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one | | (E)-1-(2- | hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one | | (E)-1-(2- | hydroxy-4,6-dimethoxyphenyl)-3-phenylpropenone | | 2'- | hydroxy-4',6'-dimethoxychalcone | | 2- | propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)- | | 2- | propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)- |
Articles:
| PubMed:The flavokawains: uprising medicinal chalcones. |
| PubMed:Multispectroscopic and molecular modeling approach to investigate the interaction of flavokawain B with human serum albumin. |
| PubMed:Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. |
| PubMed:Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. |
| PubMed:Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata. |
| PubMed:In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum). |
| PubMed:HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst. |
| PubMed:Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme. |
| PubMed:The chalcones cardamonin and flavokawain B inhibit the differentiation of preadipocytes to adipocytes by activating ERK. |
| PubMed:Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells. |
| PubMed:The flavokawains: uprising medicinal chalcones. |
| PubMed:Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. |
| PubMed:Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway. |
| PubMed:Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. |
| PubMed:Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice. |
| PubMed:The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. |
| PubMed:Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. |
| PubMed:Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression. |
| PubMed:Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo. |
| PubMed:Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. |
| PubMed:Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B. |
| PubMed:Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. |
| PubMed:Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. |
| PubMed:Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata. |
| PubMed:HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst. |
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3D/inchi