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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 185.00 to 186.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.708000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 164.00 °F. TCC ( 73.40 °C. ) (est)
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| logP (o/w): | -0.388 (est) |
| Soluble in: |
| | alcohol | | | water, 8.11e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 4920 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-rat LC50 3225 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicologist. Vol. 13, Pg. 228, 1993.
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for acrolein dimer usage levels up to: | | | not for fragrance use.
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| Recommendation for acrolein dimer flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3,4- | dihydro-(2H)-pyrane-2-carbaldehyde | | 2,3- | dihydro-1,4-pyran-2-karboxaldehyd | | 3,4- | dihydro-2H-pyran-2-carbaldehyde | | 3,4- | dihydro-2H-pyran-2-carboxaldehyde | | 2- | formyl-3,4-dihydro-2H-pyran | | 5- | hexenal, 2,6-epoxy- | | 2- | propenal dimer | | | pyran aldehyde | | 2H- | pyran-2-carboxaldehyde, 3,4-dihydro- | | a- | tolyl aldehyde dimethyl acetal | | a- | tolylaldehyde dimethyl acetal |
Articles:
| Google Patents:Acrolein dimer production |
| PubMed:Lewis Acid-Catalyzed Synthesis of Benzofurans and 4,5,6,7-Tetrahydrobenzofurans from Acrolein Dimer and 1,3-Dicarbonyl Compounds |
| PubMed:Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source |
| PubMed:Acrolein in wine: importance of 3-hydroxypropionaldehyde and derivatives in production and detection |
| PubMed:Robinetinidol-(4beta-->8)-epigallocatechin 3-O-gallate, a galloyl dimer prorobinetinidin from Acacia mearnsii De Wild, effectively protects human neuroblastoma SH-SY5Y cells against a |
| PubMed:Decontamination of Minimally-Processed Fresh Lettuce Using Reuterin Produced by Lactobacillus reuteri |
| PubMed:Hydralazine inhibits rapid acrolein-induced protein oligomerization: role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection |
| PubMed:Reference Energies for Double Excitations |
| PubMed:Acrolein with an alpha, beta-unsaturated carbonyl group inhibits LPS-induced homodimerization of toll-like receptor 4 |
| PubMed:Chemoprotectants for cancer chemotherapy |
| PubMed:Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice |
| PubMed:Cinnamaldehyde disrupts biofilm formation and swarming motility of Pseudomonas aeruginosa |
| PubMed:To Be or Not to Be: Demystifying the 2nd-Quantized Picture of Complex Electronic Configuration Patterns in Chemistry with Natural Poly-Electron Population Analysis |
| PubMed:3-hydroxypropionaldehyde: applications and perspectives of biotechnological production |
| PubMed:Effect of spermine-derived AGEs on oxidative stress and polyamine metabolism |
| PubMed:New insights into the half-of-the-sites reactivity of human aldehyde dehydrogenase 1A1 |
| PubMed:Semi-grand canonical Monte Carlo simulation of the acrolein induced surface segregation and aggregation of AgPd with machine learning surrogate models |
| PubMed:Degradation and polymerization of monolignols by Abortiporus biennis, and induction of its degradation with a reducing agent |
| PubMed:Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation |
| PubMed:Autocatalysis and organocatalysis with synthetic structures |
| PubMed:Nature and strength of C-HúúúO interactions involving formyl hydrogen atoms: computational and experimental studies of small aldehydes |
| PubMed:Synthesis and structural characterization of oaklin-catechins |
| PubMed:Ifosfamide and mesna: effects on the Na/H exchanger activity in renal epithelial cells in culture (LLC-PK1) |
| PubMed:Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules |
| PubMed:Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease |
| PubMed:Structure of polymeric polyphenols of cinnamon bark deduced from condensation products of cinnamaldehyde with catechin and procyanidins |
| PubMed:Quantitation of formaldehyde, acetaldehyde, and acetone in sidestream cigarette smoke by high-performance liquid chromatography |
| PubMed:Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents |
| PubMed:Initial steps of the peroxidase-catalyzed polymerization of coniferyl alcohol and/or sinapyl aldehyde: capillary zone electrophoresis study of pH effect |
| PubMed:Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells |
| PubMed:Tetramethylammonium hydroxide (TMAH) thermochemolysis of lignin: behavior of 4-O-etherified cinnamyl alcohols and aldehydes |
| PubMed:Purification and characterization of a novel lignin peroxidase from white-rot fungus Phanerochaete sordida YK-624 |
| PubMed:Solvent Effects on Electronically Excited States Using the Conductor-Like Screening Model and the Second-Order Correlated Method ADC(2) |
| PubMed:Reaction of tobacco smoke aldehydes with human hemoglobin |
| PubMed:Synthesis of nonracemic allylic hydroxy phosphonates via alkene cross metathesis |
| PubMed:Arene-ruthenium complexes with salicyloxazolines: diastereoselective synthesis, configurational stability and applications as asymmetric catalysts for Diels-Alder reactions |
| PubMed:A new class of synthetic biological response modifiers: the methylfurylbutyrolactones (Nafocare B) |
| PubMed:Enhanced pi ... pi interactions in alpha,beta-unsaturated carbonyls |
| PubMed:Interaction of cyclophosphamide metabolites with membrane proteins: an in vitro study with rabbit liver microsomes and human red blood cells. Effect of thiols |
| PubMed:Non-adiabatic intramolecular and photodissociation dynamics studied by femtosecond time-resolved photoelectron and coincidence imaging spectroscopy |
| PubMed:Two stable Fenton oxidation products of cyclophosphamide (NSC-26271) as precursors of 4-hydroxycyclophosphamide (NSC-196562) under physiologic conditions |
| PubMed:Biologic activity of two derivatives and six possible metabolites of cyclophosphamide (NSC-26271) |
| PubMed:[Mechanism of thermal denaturation of native trypsin and trypsin modified by neutral soluble polymer] |
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3D/inchi