EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

piroctone olamine
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)

Supplier Sponsors

CAS Number: 68890-66-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:272-574-2
FDA UNII:A4V5C6R9FB
MDL:MFCD01690792
Molecular Weight:298.42670000
Formula:C16 H30 N2 O3
NMR Predictor:Predict (works with chrome or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 344.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000004 mmHg @ 25.00 °C. (est)
Flash Point: 323.00 °F. TCC ( 161.90 °C. ) (est)
logP (o/w): 3.696 (est)
Soluble in:
 water, 18.75 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
BOC Sciences
For experimental / research use only.
Piroctone olamine 95%
ECSA Chemicals
PIROCTONE OLAMINE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Jiangyin Healthway
Piroctone Olamine
New functional food ingredients
Kingyoung Bio Technical
Piroctone
M.C.Biotec
Piroctone Olamine
Sigma-Aldrich
For experimental / research use only.
Piroctone Olamine
analytical standard
Spec-Chem Industry
SpecKare TM PO(Pirotone Olamine)
TCI AMERICA
For experimental / research use only.
Piroctone Olamine >97.0%(HPLC)(T)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 5000 mg/kg
Farmaco. Vol. 53, Pg. 405, 1998.

oral-rat LD50 8100 mg/kg
Farmaco. Vol. 53, Pg. 405, 1998.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for piroctone olamine usage levels up to:
 not for fragrance use.
 
Recommendation for piroctone olamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :50258
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
Chemidplus:0068890664
RTECS:UU7786150 for cas# 68890-66-4
 
References:
 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):50258
Pubchem (sid):135008949
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D05505
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.79.1500
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon--2-aminoethanol(1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone - 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
 octopirox
 piroctone ethanolamine salt
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1)
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
 

Articles:

PubMed:Effect of Wnt inhibitors in pancreatic cancer.
PubMed:Targeting the Wnt/beta-catenin pathway in renal cell carcinoma.
PubMed:Preparation and evaluation of the effect of Fe3 O4 @piroctone olamine magnetic nanoparticles on matrix metalloproteinase-2: a preliminary in vitro study.
PubMed:Targeting renal cancer with a combination of WNT inhibitors and a bi-functional peptide.
PubMed:Double-blinded, placebo-controlled study to evaluate an antipruritic shampoo for dogs with allergic pruritus.
PubMed:Antifungal susceptibility of dermatophytes isolated from patients with chronic renal failure.
PubMed:Increased in vivo efficacy of lenalidomide by addition of piroctone olamine.
PubMed:Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff.
PubMed:Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.
PubMed:The in vitro effect of a collagenolytic enzyme inhibitor on lesion development in root dentin.
PubMed:The antidandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo.
PubMed:Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
PubMed:Effect of residence time on the efficacy of antidandruff shampoos.
PubMed:Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair), a novel topical medical device: results of a pilot, randomized, double-blind, controlled trial.
PubMed:In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans.
PubMed:[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].
PubMed:In vitro antimycotic activity and nail permeation models of a piroctone olamine (octopirox) containing transungual water soluble technology.
PubMed:Enhanced delivery of an anti-dandruff active in a shampoo vehicle.
PubMed:Comparative anti-dandruff efficacy between a tar and a non-tar shampoo.
PubMed:[Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents].
PubMed:Malassezia furfur: a fungus belonging to the physiological skin flora and its relevance in skin disorders.
PubMed:In vitro susceptibility of Malassezia furfur.
PubMed:Evaluation de l'activité antifongique de deux dérivés et test d'innocuitéin vivo de shampooings à visée antipelliculaire ainsi formulés.
PubMed:The effect of piroctone olamine on reproduction of male and female rats.
PubMed:The effects of dietary iron supplementation on the toxicity of piroctone olamine in the growing rat.
PubMed:Percutaneous absorption of Octopirox.
PubMed:[Anti-pityriasis activity of a line of products containing piroctone olamine].
 
Notes:
2(1h)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- combined with 2-aminoethanol; used to treat pityriasis.
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