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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | -48.00 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | 463.35 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 5.400000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 419.00 °F. TCC ( 214.90 °C. ) (est)
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| logP (o/w): | 9.026 (est) |
| Soluble in: |
| | water, 0.2 mg/L @ 20 °C (exp) | | | water, 2.317e-005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for diisononyl phthalate usage levels up to: | | | not for fragrance use.
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| Recommendation for diisononyl phthalate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Di-isononylphthalate (DINP) for use in food contact materials
View page or View pdf
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Di-isodecylphthalate (DIDP) for use in food contact materials
View page or View pdf
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Technical report of the public consultation on the ‘Draft update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials’
View page or View pdf
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Update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials
View page or View pdf
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| EPI System: View |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):28553-12-0 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :34277 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| bis(3,5,5-trimethylhexyl) benzene-1,2-dicarboxylate |
| Chemidplus:0014103618 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:28553-12-0 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | baylectrol 4200 | | 1,2- | benzene dicarboxylic acid diisononyl ester | | 1,2- | benzenedicarboxylic acid bis(3,5,5-trimethylhexyl) ester | | 1,2- | benzenedicarboxylic acid, bis(3,5,5-trimethylhexyl) ester | | 1,2- | benzenedicarboxylic acid, diisononyl ester | | | di-''isononyl'' phthalate | | | diisononylphthalate | | | DINP2 | | | DINP3 | | | JAY-DINP | | | jayflex DINP | | | palatinol DN | | | palatinol N | | | phthalic acid, diisononyl ester | | | phthalisocizer DINP | | | plasthall DINP | | | sansocizer DINP | | bis(3,5,5- | trimethylhexyl) phthalate | | | vestinol 9 | | | vestinol NN | | | vinylcizer 90 | | | witamol 150 |
Articles:
| PubMed:Generation of hazard indices for cumulative exposure to phthalates for use in cumulative risk assessment. |
| PubMed:Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin. |
| PubMed:Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. |
| PubMed:Dispersive solid-phase extraction based on magnetic dummy molecularly imprinted microspheres for selective screening of phthalates in plastic bottled beverages. |
| PubMed:Semivolatile organic compounds in indoor air and settled dust in 30 French dwellings. |
| PubMed:Associations between serum phthalates and biomarkers of reproductive function in 589 adult men. |
| PubMed:Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice. |
| PubMed:Ecological risk assessment of chemicals migrated from a recycled plastic product. |
| PubMed:Emissions of two phthalate esters and BDE 209 to indoor air and their impact on urban air quality. |
| PubMed:[The occurrence of plasticisers (phthalates) in communal facilities under special consideration of results from LUPE 3]. |
| PubMed:Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP). |
| PubMed:Adverse effects of diisooctyl phthalate on the male rat reproductive development following prenatal exposure. |
| PubMed:[Hazardous endocrine disruptors. Phthalates in our hospital]. |
| PubMed:Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000-2012). |
| PubMed:Analysis of selected phthalates in Canadian indoor dust collected using household vacuum and standardized sampling techniques. |
| PubMed:Determination of phthalate diesters in foods. |
| PubMed:[Toxicity effects of phthalate substitute plasticizers used in toys]. |
| PubMed:[Determination of phthalic acid esters in imitation jewellery and investigation of their migration risk]. |
| PubMed:Urinary biomarkers for phthalates associated with asthma in Norwegian children. |
| PubMed:A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development. |
| PubMed:Plasticizer incident and its health effects in Taiwan. |
| PubMed:Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men. |
| PubMed:Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats. |
| PubMed:Effects of 4-nonylphenol and/or diisononylphthalate on THP-1 cells: impact of endocrine disruptors on human immune system parameters. |
| PubMed:[Determination of 23 phthalate esters in food by solid-phase extraction coupled with gas chromatography-mass spectrometry]. |
| PubMed:Dummy molecularly imprinted solid-phase extraction for selective determination of five phthalate esters in plastic bottled functional beverages. |
| PubMed:Human biological monitoring of diisononyl phthalate and diisodecyl phthalate: a review. |
| PubMed:[Survey of plasticizers in polyvinyl chloride toys]. |
| PubMed:High urinary phthalate concentration associated with delayed pubarche in girls. |
| PubMed:Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: temporal trends and timing of amniocentesis in pregnancy. |
| PubMed:Endocrine disruptors and asthma-associated chemicals in consumer products. |
| PubMed:A comprehensive review of intake estimates of di-isononyl phthalate (DINP) based on indirect exposure models and urinary biomonitoring data. |
| PubMed:[Test method for 6 phthalates in polyvinyl chloride]. |
| PubMed:Identification of di-isononyl phthalate metabolites for exposure marker discovery using in vitro/in vivo metabolism and signal mining strategy with LC-MS data. |
| PubMed:Beyond phthalates: gas phase concentrations and modeled gas/particle distribution of modern plasticizers. |
| PubMed:Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan. |
| PubMed:Phthalate exposure during cold plastisol application--a human biomonitoring study. |
| PubMed:Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations. |
| PubMed:Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate. |
| PubMed:Biomonitoring equivalents for di-isononyl phthalate (DINP). |
| PubMed:Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats. |
| PubMed:Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey. |
| PubMed:Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth. |
| PubMed:Determination of five phthalate monoesters in human urine using gas chromatography-mass spectrometry. |
| PubMed:Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro. |
| PubMed:Determination of phthalates in diet and bedding for experimental animals using gas chromatography-mass spectrometry. |
| PubMed:Rapid and nondestructive analysis of phthalic acid esters in toys made of poly(vinyl chloride) by direct analysis in real time single-quadrupole mass spectrometry. |
| PubMed:Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland. |
| PubMed:Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions. |
| PubMed:Phthalates and nonylphenols in urban runoff: Occurrence, distribution and area emission factors. |
| PubMed:P450(BM-3)-catalyzed whole-cell biotransformation of alpha-pinene with recombinant Escherichia coli in an aqueous-organic two-phase system. |
| PubMed:Hazard to the developing male reproductive system from cumulative exposure to phthalate esters--dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate. |
| PubMed:Biodegradation of a phthalate plasticizer, di-isononyl phthalate (DINP), by Sphingobium chungbukense. |
| PubMed:Phthalates: metabolism and exposure. |
| PubMed:Metabolism of phthalates in humans. |
| PubMed:Urinary metabolites of diisodecyl phthalate in rats. |
| PubMed:Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP. |
| PubMed:[Determination of phthalic acid esters in textiles by solid phase extraction-gas chromatography]. |
| PubMed:[Survey of epoxidized soybean oil in cap sealing for bottled foods]. |
| PubMed:Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment. |
| PubMed:Urinary biomarkers of di-isononyl phthalate in rats. |
| PubMed:Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats. |
| PubMed:Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment. |
| PubMed:Modulation of iodide uptake by dialkyl phthalate plasticisers in FRTL-5 rat thyroid follicular cells. |
| PubMed:Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring. |
| PubMed:Hazard evaluation of diisononyl phthalate and diisodecyl phthalate in a Japanese medaka multigenerational assay. |
| PubMed:Risk assessment of oral exposure to diisononyl phthalate from children's products. |
| PubMed:Enhancement of interleukin-4 production in activated CD4+ T cells by diphthalate plasticizers via increased NF-AT binding activity. |
| PubMed:Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats. |
| PubMed:Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals. |
| PubMed:Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. |
| PubMed:[Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products]. |
| PubMed:Role of the peroxisome proliferator-activated receptor alpha in responses to diisononyl phthalate. |
| PubMed:[Estimation of daily oral exposure to phthalates derived from soft polyvinyl chloride baby toys]. |
| PubMed:Determination of phthalate ester congeners and mixtures by LC/ESI-MS in sediments and biota of an urbanized marine inlet. |
| PubMed:Pediatric exposure and potential toxicity of phthalate plasticizers. |
| PubMed:Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. |
| PubMed:A simple and reproducible testing method for dialkyl phthalate migration from polyvinyl chloride products into saliva simulant. |
| PubMed:[Contents of plasticizers in cap-sealing for bottled food and their migration into food]. |
| PubMed:Adjuvant effect of di-n-butyl-, di-n-octyl-, di-iso-nonyl- and di-iso-decyl phthalate in a subcutaneous injection model using BALB/c mice. |
| PubMed:Gas chromatography-mass spectrometry determination of the migration of phthalate plasticisers from polyvinyl chloride toys and childcare articles. |
| PubMed:Comments on Foster, P., and McIntyre, B. (2002). Endocrine active agents: implications of adverse and non-adverse changes. Toxicol Pathol 30(1): 59-65. |
| PubMed:Tumor induction in mouse liver: di-isononyl phthalate acts via peroxisome proliferation. |
| PubMed:NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate. |
| PubMed:Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats. |
| PubMed:Species differences in response to the phthalate plasticizer monoisononylphthalate (MINP) in vitro: a comparison of rat and human hepatocytes. |
| PubMed:Migration of phthalates from PVC toys into saliva simulant by dynamic extraction. |
| PubMed:An assessment of the toxicity of phthalate esters to freshwater benthos. 2. Sediment exposures. |
| PubMed:[Contents of eleven phthalates and di(2-ethylhexyl) adipate in retail packed lunches after prohibition of DEHP-containing PVC gloves for cooking purposes]. |
| PubMed:[Contents of phthalate in polyvinyl chloride toys]. |
| PubMed:Analysis of plasticizers in cap-sealing resins for bottled foods. |
| PubMed:Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate (DIDP) are not mutagenic. |
| PubMed:Response letter from ACSH phthalate panel. |
| PubMed:Letter in response to ACSH report on plasticizers. |
| PubMed:Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. |
| PubMed:The role of inhibition of gap junctional intercellular communication in rodent liver tumor induction by phthalates: review of data on selected phthalates and the potential relevance to man. |
| PubMed:Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys. |
| PubMed:Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver. |
| PubMed:Concentrations of phthalate esters and identification of other additives in PVC children's toys. |
| PubMed:Two-generation reproduction study in rats given di-isononyl phthalate in the diet. |
| PubMed:Suppression of apoptosis and induction of DNA synthesis in vitro by the phthalate plasticizers monoethylhexylphthalate (MEHP) and diisononylphthalate (DINP): a comparison of rat and human hepatocytes in vitro. |
| PubMed:The potential health effects of phthalate esters in children's toys: a review and risk assessment. |
| PubMed:Retrospective evaluation of alpha 2u-globulin accumulation in male rat kidneys following high doses of diisononyl phthalate. |
| PubMed:Effects of di-isononyl phthalate (DINP) on peroxisomal markers in the marmoset-DINP is not a peroxisome proliferator. |
| PubMed:Developmental toxicity of di-isodecyl and di-isononyl phthalates in rats. |
| PubMed:Analysis of potentially toxic phthalate plasticizers used in toy manufacturing. |
| PubMed:Differential prenatal toxicity of branched phthalate esters in rats. |
| PubMed:Biodegradation of DEHP, DBP, and DINP: poorly water soluble and widely used phthalate plasticizers. |
| PubMed:Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats. |
| PubMed:Sqwish Ball dermatitis. |
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3D/inchi