|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | -76.50 °C. @ 760.00 mm Hg
|
| Boiling Point: | 104.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 30.000000 mmHg @ 20.00 °C. (est) |
| Flash Point: | 40.00 °F. TCC ( 4.60 °C. ) (est)
|
| logP (o/w): | 0.771 (est) |
| Soluble in: |
| | water, 1.81E+05 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-cat LDLo 30 mg/kg
BLOOD: OTHER CHANGES
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 275, 1952.
oral-mouse LD50 104 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(8), Pg. 53, 1982.
oral-rat LD50 80 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 62(3), Pg. 3, 1997.
|
| Dermal Toxicity: |
skin-guinea pig LD50 30 uL/kg
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.
skin-rabbit LD50 380 uL/kg
Union Carbide Data Sheet. Vol. 4/21/1967
|
| Inhalation Toxicity: |
inhalation-mouse LC50 580 mg/m3/2H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(8), Pg. 53, 1982.
inhalation-rat LC50 200 mg/m3/2H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(8), Pg. 53, 1982.
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 2-butenal usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for 2-butenal flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | but-2-enal | | 2- | buten-1-al | | 2- | butenal propylene aldelhyde | | 2- | butenaldehyde | | | crotonaldehyde | | | crotonic aldehyde | | | crotyl aldehyde | | 1- | formyl propene | | 1- | formylpropene | | beta- | methyl acrolein | | | methyl propenal |
Articles:
| US Patents:8,173,822 - 1,3-oxathiane compounds and their use in flavor and fragrance compositions |
| PubMed:Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L. |
| PubMed:Transport of hop aroma compounds across Caco-2 monolayers. |
| PubMed:Development of three stable isotope dilution assays for the quantitation of (E)-2-butenal (crotonaldehyde) in heat-processed edible fats and oils as well as in food. |
| PubMed:Growth Inhibitory Effect of (E)-2,4-bis(p-hydroxyphenyl)-2-Butenal Diacetate through Induction of Apoptotic Cell Death by Increasing DR3 Expression in Human Lung Cancer Cells. |
| PubMed:Effects of aliphatic aldehydes on the growth and patulin production of Penicillium expansum in apple juice. |
| PubMed:Mutagenic/recombinogenic effects of four lipid peroxidation products in Drosophila. |
| PubMed:Small reactive carbonyl compounds as tissue lipid oxidation products; and the mechanisms of their formation thereby. |
| PubMed:On-fiber furan formation from volatile precursors: a critical example of artefact formation during Solid-Phase Microextraction. |
| PubMed:The potential of biodetoxification activity as a probiotic property of Lactobacillus reuteri. |
| PubMed:[13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells. |
| PubMed:Gas chromatography/sniffing port analysis of aroma compounds released under mouth conditions. |
| PubMed:Chemical profile of rums as a function of their origin. The use of chemometric techniques for their identification. |
| PubMed:Direct aldehyde homologation utilized to construct a conjugated-tetraene hydrocarbon insect pheromone. |
| PubMed:Difference in the volatile composition of pine-mushrooms (Tricholoma matsutake Sing.) according to their grades. |
| PubMed:Changes induced by UV radiation during virgin olive oil storage. |
| PubMed:How cysteine reacts with citral: an unexpected reaction of beta,beta-disubstituted acroleins with cysteine leading to hexahydro-1,4-thiazepines. |
| PubMed:The unbearable lightness of "light" cigarettes: a comparison of smoke yields in six varieties of Canadian "light" cigarettes. |
| PubMed:Origin and mechanistic pathways of formation of the parent furan--a food toxicant. |
| PubMed:Analysis of a model reaction system containing cysteine and (E)-2-methyl-2-butenal, (E)-2-hexenal, or mesityl oxide. |
| PubMed:Aldehyde-induced xanthine oxidase activity in raw milk. |
| PubMed:A novel, inducible, citral lyase purified from spores of Penicillium digitatum. |
| PubMed:Aroma active components in aqueous kiwi fruit essence and kiwi fruit puree by GC-MS and multidimensional GC/GC-O. |
| PubMed:Identification of aroma compounds in Parmigiano-Reggiano cheese by gas chromatography/olfactometry. |
| PubMed:The influence of the solvents DMSO and ethanol on the genotoxicity of alpha,beta-unsaturated aldehydes in the SOS chromotest. |
| PubMed:Cancer risk assessment for the environmental mutagen and carcinogen crotonaldehyde on the basis of TD(50) and comparison with 1,N(2)-propanodeoxyguanosine adduct levels. |
| PubMed:Endogenous formation of protein adducts with carcinogenic aldehydes: implications for oxidative stress. |
| PubMed:Development of a 32P-postlabelling method for the detection of 1,N2-propanodeoxyguanosine adducts of crotonaldehyde in vivo. |
| PubMed:Volatile aldehydes are promising broad-spectrum postharvest insecticides. |
| PubMed:Detection of 1,N(2)-propanodeoxyguanosine adducts in DNA of Fischer 344 rats by an adapted (32)P-post-labeling technique after per os application of crotonaldehyde. |
| PubMed:Detection of 1,N2-propanodeoxyguanosine adducts of 2-hexenal in organs of Fischer 344 rats by a 32P-post-labeling technique. |
| PubMed:Cellular response to the redox active lipid peroxidation products: induction of glutathione S-transferase P by 4-hydroxy-2-nonenal. |
| PubMed:(E)-2-hexenal-induced DNA damage and formation of cyclic 1,N2-(1,3-propano)-2'-deoxyguanosine adducts in mammalian cells. |
| PubMed:Crotonaldehyde: a carcinogenic and mutagenic air, water and food pollutant. |
| PubMed:The influence of glutathione and detoxifying enzymes on DNA damage induced by 2-alkenals in primary rat hepatocytes and human lymphoblastoid cells. |
| PubMed:Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment. |
| PubMed:Formation of odorous compounds from hydrogen sulphide and 2-butenal. |
|
3D/inchi