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Category:preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 98.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 54.00 to 58.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 344.00 to 345.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000032 mmHg @ 25.00 °C. (est) |
| Flash Point: | 324.00 °F. TCC ( 162.20 °C. ) (est)
|
| logP (o/w): | 4.760 |
| Soluble in: |
| | water, 10 mg/L @ 20 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 3700 mg/kg
"Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970.
oral-mouse LD50 4530 mg/kg
"Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970.
intraperitoneal-mouse LD50 84 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.
intraperitoneal-rat LD50 89 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.
intravenous-rat LD50 29 mg/kg
Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969.
|
| Dermal Toxicity: |
skin-rabbit LD50 9300 mg/kg
Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969.
subcutaneous-mouse LD50 3800 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.
subcutaneous-rat LD50 3900 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | preservatives |
| Recommendation for triclosan usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for triclosan flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to a 3rd list of substances for food contact materials
View page or View pdf
|
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):3380-34-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5564 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 5-chloro-2-(2,4-dichlorophenoxy)phenol |
| Chemidplus:0003380345 |
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C12059 |
| HMDB (The Human Metabolome Database): | Search |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•trade names: aquasept, gamophen, irgasan dp 300, sapoderm, ster-zac
•vinyzene dp 7000 (rohm and haas company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%.
•vinyzene sb-30 (rohm and haas company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 10%.
•sanitized brand t96-21 (sanitized inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 10%.
•sanitized brand pla (sanitized inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99.9%.
•waste minders with stangard4 (s.c. johnson & son inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- .06%.
•microbanish r (troy chemical corp): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%.
•vikol thp (vikon chemical company, inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 2%.
•ultrafresh 300 dd nonionic (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 1.6%, bis(tributyltin) oxide 1.06%.
•ultra fresh nm (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 3%.
•ultra fresh nm-100 (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%.
•ultra-fresh ft-7 (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 1%, octhilinone 6.1%.
•microban additive "b" (microban products company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%.
•viv-20 (triclosan) (microban products company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99.9%.
•aerisguard bioactive coil treatment (aeris environmental ltd): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- .69%.
•invasan am 110 us (huntsman international, llc): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 10%.
•superclear t100 (pulcra chemicals, llc): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99.9%.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5- | chlor-2-(2,4-dichlorphenoxy)phenol | | 5- | chloro-(2,4-dichlorophenoxy)phenol | | 5- | chloro-2-(2,4-dichlorophenoxy)phenol | | | cliniclean | | | cloxifenol | | | cloxifenolum | | 2-(2,4- | dichlorophenoxy)-5-chlorophenol | | | ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl | | 2- | hydroxy-2',4,4'-trichlorodiphenyl ether | | | irgasan | | | manusept | | | microban B | | | phenol, 5-chloro-2-(2,4-dichlorophenoxy)- | | | sapoderm | | | symguard CD | | 2,4,4'- | trichloro-2'-hydroxy diphenyl ether | | 2,4,4'- | trichloro-2'-hydroxydiphenyl ether | | 2,4,4'- | trichloro-2'-hydroxydiphenylether |
Articles:
| PubMed:Determination of plaque viability following a single brushing with commercial toothpastes. |
| PubMed:Comparison of the short-term antiplaque/antibacterial efficacy of two commercial dentifrices. |
| PubMed:The technology behind Colgate Total Advanced Fresh. |
| PubMed:A model for studying the effects of mouthrinses on de novo plaque formation. |
| PubMed:Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products. |
| PubMed:News, views, & reviews. Update on antibacterial soaps: the FDA takes a second look at triclosans. |
| PubMed:Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. |
| PubMed:Development of a multi-preservative method based on solid-phase microextraction-gas chromatography-tandem mass spectrometry for cosmetic analysis. |
| PubMed:Triclosan Induced Aminoglycoside-Tolerant Listeria monocytogenes Isolates can appear as Small-Colony Variants. |
| PubMed:Assessment of toxic effects of triclosan on the terrestrial snail (Achatina fulica). |
| PubMed:Urinary concentrations of environmental phenols in pregnant women in a pilot study of the National Children's Study. |
| PubMed:Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women. |
| PubMed:Uptake and accumulation of antimicrobials, triclocarban and triclosan, by food crops in a hydroponic system. |
| PubMed:Identification of plant metabolites of environmental contaminants by UPLC-QToF-MS: the in vitro metabolism of triclosan in horseradish. |
| PubMed:FDA pushes makers of antimicrobial soap to prove safety and effectiveness. |
| PubMed:Fate and uptake of pharmaceuticals in soil-plant systems. |
| PubMed:Triclocarban, triclosan and its transformation product methyl triclosan in native earthworm species four years after a commercial-scale biosolids application. |
| PubMed:Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. |
| PubMed:Analysis of triclosan-selected Salmonella enterica mutants of eight serovars revealed increased aminoglycoside susceptibility and reduced growth rates. |
| PubMed:Analytical performance of two miniaturised extraction methods for triclosan and methyltriclosan, in fish roe and surimi samples. |
| PubMed:Transcriptomic analysis of triclosan-susceptible and -tolerant Escherichia coli O157:H19 in response to triclosan exposure. |
| PubMed:Biocide and copper tolerance in enterococci from different sources. |
| PubMed:Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity. |
| PubMed:Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. |
| PubMed:Bioconcentration of triclosan and methyl-triclosan in marine mussels (Mytilus galloprovincialis) under laboratory conditions and in metropolitan waters of Gulf St Vincent, South Australia. |
| PubMed:Oregano essential oil as an antimicrobial additive to detergent for hand washing and food contact surface cleaning. |
| PubMed:Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring. |
| PubMed:Foliar sorption of emerging and priority contaminants under controlled conditions. |
| PubMed:Small colony variants (SCVs) of Staphylococcus aureus--a bacterial survival strategy. |
| PubMed:Antibacterial electrospun poly(lactic acid) (PLA) nanofibrous webs incorporating triclosan/cyclodextrin inclusion complexes. |
| PubMed:Comparative analysis of the susceptibility to triclosan and three other biocides of avian Salmonella enterica isolates collected 1979 through 1994 and 2004 through 2010. |
| PubMed:Combined treatments of enterocin AS-48 with biocides to improve the inactivation of methicillin-sensitive and methicillin-resistant Staphylococcus aureus planktonic and sessile cells. |
| PubMed:Assessment of the susceptibility of lactic acid bacteria to biocides. |
| PubMed:Comparison of degradation between indigenous and spiked bisphenol A and triclosan in a biosolids amended soil. |
| PubMed:Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts. |
| PubMed:Proteomic and phenotypic analysis of triclosan tolerant verocytotoxigenic Escherichia coli O157:H19. |
| PubMed:Development of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli adapted to biocides. |
| PubMed:Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012. |
| PubMed:How dirty are the dirty dozen ingredients in cosmetics? |
| PubMed:Effects of efflux-pump inducers and genetic variation of the multidrug transporter cmeB in biocide resistance of Campylobacter jejuni and Campylobacter coli. |
| PubMed:Triclosan exposure and allergic sensitization in Norwegian children. |
| PubMed:Metabolization of the bacteriostatic agent triclosan in edible plants and its consequences for plant uptake assessment. |
| PubMed:Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine. |
| PubMed:Uptake of galaxolide, tonalide, and triclosan by carrot, barley, and meadow fescue plants. |
| PubMed:Toxicity and bioaccumulation of biosolids-borne triclosan in food crops. |
| PubMed:Triple bioaffinity mass spectrometry concept for thyroid transporter ligands. |
| PubMed:Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells. |
| PubMed:Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. |
| PubMed:Comparative proteomic analysis of Salmonella tolerance to the biocide active agent triclosan. |
| PubMed:Efficacy of biocides used in the modern food industry to control salmonella enterica, and links between biocide tolerance and resistance to clinically relevant antimicrobial compounds. |
| PubMed:Transfer of Salmonella Enteritidis to four types of surfaces after cleaning procedures and cross-contamination to tomatoes. |
| PubMed:Involvement of efflux mechanisms in biocide resistance of Campylobacter jejuni and Campylobacter coli. |
| PubMed:Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women. |
| PubMed:An expert panel report of a proposed scientific model demonstrating the effectiveness of antibacterial handwash products. |
| PubMed:Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field. |
| PubMed:Miniaturized extraction methods of triclosan from aqueous and fish roe samples. Bioconcentration studies in zebrafish larvae (Danio rerio). |
| PubMed:Uptake of organic emergent contaminants in spath and lettuce: an in vitro experiment. |
| PubMed:Effect of enterocin AS-48 in combination with biocides on planktonic and sessile Listeria monocytogenes. |
| PubMed:Review of risk from potential emerging contaminants in UK groundwater. |
| PubMed:Field dissipation of 4-nonylphenol, 4-t-octylphenol, triclosan and bisphenol A following land application of biosolids. |
| PubMed:Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain). |
| PubMed:A meta-analysis of the published literature on the effectiveness of antimicrobial soaps. |
| PubMed:Sensitivity analysis for the SimpleTreat model to simulate fate of chemicals in sewage treatment plants. |
| PubMed:Determination of preservative and antimicrobial compounds in fish from Manila Bay, Philippines using ultra high performance liquid chromatography tandem mass spectrometry, and assessment of human dietary exposure. |
| PubMed:4-Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels. |
| PubMed:Sublethal triclosan exposure decreases susceptibility to gentamicin and other aminoglycosides in Listeria monocytogenes. |
| PubMed:Degradation of 4-nonylphenol, 4-t-octylphenol, bisphenol A and triclosan following biosolids addition to soil under laboratory conditions. |
| PubMed:In vitro interaction between fluconazole and triclosan against clinical isolates of fluconazole-resistant Candida albicans determined by different methods. |
| PubMed:Inappropriate use of D-values for determining biocidal activity of various antimicrobials. |
| PubMed:Effect of active packaging incorporated with triclosan on bacteria adhesion. |
| PubMed:Uptake of 17α-ethynylestradiol and triclosan in pinto bean, Phaseolus vulgaris. |
| PubMed:Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry. |
| PubMed:Assessment of the antibacterial activity of a triclosan-containing cutting board. |
| PubMed:Listeria monocytogenes and Salmonella enterica enteritidis biofilms susceptibility to different disinfectants and stress-response and virulence gene expression of surviving cells. |
| PubMed:Effectiveness of triclosan in the management of radiation-induced oral mucositis: a randomized clinical trial. |
| PubMed:Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter. |
| PubMed:Salmonella enterica Enteritidis biofilm formation and viability on regular and triclosan-impregnated bench cover materials. |
| PubMed:Comparative efficacy of seven hand sanitizers against murine norovirus, feline calicivirus, and GII.4 norovirus. |
| PubMed:Selected personal care products and endocrine disruptors in biosolids: an Australia-wide survey. |
| PubMed:A review of personal care products in the aquatic environment: environmental concentrations and toxicity. |
| PubMed:Fully automated determination of parabens, triclosan and methyl triclosan in wastewater by microextraction by packed sorbents and gas chromatography-mass spectrometry. |
| PubMed:Occurrence, efficacy, metabolism, and toxicity of triclosan. |
| PubMed:Probabilistic risk evaluation for triclosan in surface water, sediments, and aquatic biota tissues. |
| PubMed:Review of 'emerging' organic contaminants in biosolids and assessment of international research priorities for the agricultural use of biosolids. |
| PubMed:In-sample acetylation-non-porous membrane-assisted liquid-liquid extraction for the determination of parabens and triclosan in water samples. |
| PubMed:Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. |
| PubMed:The synergistic activity of triclosan and ciprofloxacin on biofilms of Salmonella Typhimurium. |
| PubMed:Electrochemical sensor for rapid detection of triclosan using a multiwall carbon nanotube film. |
| PubMed:Organic contaminants in sewage sludge (biosolids) and their significance for agricultural recycling. |
| PubMed:Impact of biosolids on the persistence and dissipation pathways of triclosan and triclocarban in an agricultural soil. |
| PubMed:Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium. |
| PubMed:Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field. |
| PubMed:Adsorption and degradation of triclosan and triclocarban in soils and biosolids-amended soils. |
| PubMed:Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry. |
| PubMed:Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field. |
| PubMed:Association of triclosan to casein proteins through solvent-mediated high-pressure homogenization. |
| PubMed:Development of triclosan and antibiotic resistance in Salmonella enterica serovar Typhimurium. |
| PubMed:An ecological risk assessment for triclosan in the terrestrial environment. |
| PubMed:Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1. |
| PubMed:Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. |
| PubMed:Determinations and residual characteristics of triclosan in household food detergents of Taiwan. |
| PubMed:Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids. |
| PubMed:Polychlorinated dibenzo-p-dioxins and dibenzofurans pollution in China: sources, environmental levels and potential human health impacts. |
| PubMed:Snail bioaccumulation of triclocarban, triclosan, and methyltriclosan in a North Texas, USA, stream affected by wastewater treatment plant runoff. |
| PubMed:Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field. |
| PubMed:Simplified sample preparation method for triclosan and methyltriclosan determination in biota and foodstuff samples. |
| PubMed:Antibiotic and disinfectant susceptibility profiles of vancomycin-resistant Enterococcus faecium (VRE) isolated from community wastewater in Texas. |
| PubMed:Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta. |
| PubMed:Antimicrobial susceptibility of Listeria monocytogenes from food products. |
| PubMed:Measurement of triclosan in water using a magnetic particle enzyme immunoassay. |
| PubMed:Effect of triclosan on Salmonella typhimurium at different growth stages and in biofilms. |
| PubMed:Efflux pump activity in fluoroquinolone and tetracycline resistant Salmonella and E. coli implicated in reduced susceptibility to household antimicrobial cleaning agents. |
| PubMed:Risk assessment of triclosan [Irgasan] in human breast milk. |
| PubMed:Triclosan and antimicrobial resistance in bacteria: an overview. |
| PubMed:Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase. |
| PubMed:Evaluation of the antibacterial effect of a triclosan-containing floor used in the food industry. |
| PubMed:Environmental oestrogens, cosmetics and breast cancer. |
| PubMed:Inhibition of sulfotransferases by xenobiotics. |
| PubMed:Assessment of benefits from use of antimicrobial hand products: reduction in risk from handling ground beef. |
| PubMed:A unique water optional health care personnel handwash provides antimicrobial persistence and residual effects while decreasing the need for additional products. |
| PubMed:Possible associations between Salmonella persistence in poultry houses and resistance to commonly used disinfectants and a putative role of mar. |
| PubMed:Inhibition of fatty acid synthase prevents preadipocyte differentiation. |
| PubMed:Determination of triclosan in foodstuffs. |
| PubMed:Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica. |
| PubMed:The effect of a toothpaste containing 2% zinc citrate/0.3% Triclosan on the glycolysis of plaque bacteria ex vivo after food intake. |
| PubMed:The effect of a 2% zinc citrate, 0.3% Triclosan dentifrice on plaque acid production following consumption of a snackfood. |
| PubMed:Plaque antibacterial levels following controlled food intake and use of a toothpaste containing 2% zinc citrate and 0.3% Triclosan. |
| PubMed:Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages. |
| PubMed:Antimicrobial food packaging in meat industry. |
| PubMed:Effectiveness of some recent antimicrobial packaging concepts. |
| PubMed:[Can disinfectants contribute to antibiotic resistance?]. |
| PubMed:The comparative anticaries efficacy of a dentifrice containing 0.3% triclosan and 2.0% copolymer in a 0.243% sodium fluoride/silica base and a dentifrice containing 0.243% sodium fluoride/silica base: a two-year coronal caries clinical trial on adults in Israel. |
| PubMed:Determination of phenolic disinfectant agents in commercial formulations by liquid chromatography. |
| PubMed:A method of assessing the efficacy of hand sanitizers: use of real soil encountered in the food service industry. |
| PubMed:Percutaneous penetration and dermal metabolism of triclosan (2,4, 4'-trichloro-2'-hydroxydiphenyl ether). |
| PubMed:The influence of specific foods and oral hygiene on the microflora of fissures and smooth surfaces of molar teeth: A 5-day study. |
| PubMed:The effectiveness of triclosan-incorporated plastic against bacteria on beef surfaces. |
| PubMed:[Analysis of components in natural food additive "grapefruit seed extract" by HPLC and LC/MS]. |
| PubMed:Dietary staining in vitro by mouthrinses as a comparative measure of antiseptic activity and predictor of staining in vivo. |
| PubMed:Evaluation of the skin disinfecting activity and cumulative effect of chlorhexidine and triclosan handwash preparations on hands artificially contaminated with Serratia marcescens. |
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3D/inchi