sodium citrate anhydrous, 68-04-2

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Product(s):
68-04-2 Sodium citrate,anhydrous 99%

Glentham Life Sciences Ltd

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Product(s):
GK2264 Sodium citrate, anhydrous

Lluch Essence S.L.

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Product(s):
SODIUM CITRATE NATURAL

M&U International LLC

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Product(s):
A0232 Sodium Citrate, Kosher

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Product(s):
19-27450 SODIUM CITRATE ANHYDROUS GRANULAR USP - FCC
20-85500 TRISODIUM CITRATE
19-27500 SODIUM CITRATE ANHYDROUS POWDER USP - FCC

Name:	trisodium 2-hydroxypropane-1,2,3-tricarboxylate
CAS Number:	68-04-2	3D/inchi
ECHA EINECS - REACH Pre-Reg:	200-675-3
FDA UNII:	RS7A450LGA
Nikkaji Web:	J1.168A
MDL:	MFCD00012462
Molecular Weight:	258.06955784
Formula:	C6 H5 Na3 O7
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:preservatives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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	FDA/DG SANTE Petitions, Reviews, Notices:
184.1751	Sodium citrate View - review
EU SANCO	Sodium citrates View - review
JECFA Food Additive:	Trisodium Citrate
GSFA Codex:	Trisodium citrate (331(iii))
FDA Mainterm (SATF):	68-04-2 ; TRISODIUM CITRATE
FDA Regulation:
FDA PART 131 -- MILK AND CREAM Subpart B--Requirements for Specific Standardized Milk and Cream Sec. 131.111 Acidified milk. FDA PART 131 -- MILK AND CREAM Subpart B--Requirements for Specific Standardized Milk and Cream Sec. 131.112 Cultured milk. FDA PART 131 -- MILK AND CREAM Subpart B--Requirements for Specific Standardized Milk and Cream Sec. 131.160 Sour cream. FDA PART 131 -- MILK AND CREAM FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS Subpart B--Requirements for Specific Standardized Cheese and Related Products Sec. 133.169 Pasteurized process cheese. FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS Subpart B--Requirements for Specific Standardized Cheese and Related Products Sec. 133.173 Pasteurized process cheese food. FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS Subpart B--Requirements for Specific Standardized Cheese and Related Products Sec. 133.179 Pasteurized process cheese spread. FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products Sec. 150.141 Artificially sweetened fruit jelly. FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products Sec. 150.161 Artificially sweetened fruit preserves and jams. FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS Subpart C--Substances for Use as Components of Coatings Sec. 175.300 Resinous and polymeric coatings. FDA PART 179 -- IRRADIATION IN THE PRODUCTION, PROCESSING AND HANDLING OF FOOD Subpart C--Packaging Materials for Irradiated Foods Sec. 179.45 Packaging materials for use during the irradiation of prepackaged foods. FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS Subpart B--Specific Prior-Sanctioned Food Ingredients Sec. 181.29 Stabilizers. FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE Subpart B--Listing of Specific Substances Affirmed as GRAS Sec. 184.1751 Sodium citrate.

Physical Properties:

Appearance:	white crystalline powder (est)
Assay:	99.00 to 100.00
Food Chemicals Codex Listed:	No
logP (o/w):	-0.280 (est)
Soluble in:
	water, 1.2e+005 mg/L @ 25 °C (est)
	water, 4.34E+05 mg/L @ C (exp)
Insoluble in:
	alcohol

Organoleptic Properties:

Odor Strength:none

Odor Description:at 100.00 %. odorless

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	buffering agents chelating agents fragrance

Suppliers:

ADM

Sodium Citrate Anhydrous Powder

Odor: odorless

Use: Sodium Citrate Anhydrous is derived from citric acid and is available in either free-flowing colorless granular, fine granular or powder forms. It is odorless and freely soluble in water, but insoluble in alcohol. Storage at room temperature in tightly sealed containers is recommended. Sodium citrate dihydrate is the most broadly used emulsifying salt in sliced processed cheese products. It is commonly used as a buffering agent in combination with citric acid to provide precise pH control required in many food and beverage applications. In meat products it is used as an anticoagulant of fresh livestock blood and as a curing accelerator. The detergent-building and rapid biodegradability characteristics of sodium citrate enable its use as an environmentally acceptable phosphate substitute in a large variety of household cleaning products.

ADM

Sodium Citrate Anhydrous, USP/FCC

Atlantic Chemicals

Trisodium Citrate

BOC Sciences

For experimental / research use only.

Sodium citrate,anhydrous 99%

Glentham Life Sciences

Sodium citrate, anhydrous

Graham Chemical

Sodium Citrate

Jungbunzlauer Suisse

Trisodium Citrate Anhydrous

Flavor: characteristic

Trisodium citrate is a tribasic salt of citric acid. It is produced by complete neutralisation of citric acid with high purity sodium hydroxide or carbonate and subsequent crystallisation and dehydration. The common hydrate form, trisodium citrate dihydrate, is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent, whereas the anhydrous form finds its uses in particular applications such as water sensitive dry blends and instant beverages, surfactants, fragrances as well as in tablets and OTC products. Jungbunzlauer trisodium citrate anhydrous is manufactured from trisodium citrate dihydrate. Water molecules of the dihydrate crystals are removed by a patented process without destroying the original crystal matrix. The resulting crystals have a porous matrix that can be used as a carrier for inorganic and/or organic substances, especially after being impregnated with liquids. Further, due to the absence of water, the product is not prone to caking. Trisodium citrate anhydrous is also used in applications where excess water is not desired.

Lluch Essence

SODIUM CITRATE NATURAL

M&U International

Sodium Citrate, Kosher

Penta International

SODIUM CITRATE ANHYDROUS GRANULAR USP - FCC

Penta International

SODIUM CITRATE ANHYDROUS POWDER USP - FCC

Penta International

TRISODIUM CITRATE

Sigma-Aldrich

For experimental / research use only.

Citric acid trisodium salt ≥98% (GC), anhydrous

Tianjin Talent Chemical

Trisodium Citrate

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 1548 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948. intravenous-rabbit LD50 449 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948. intravenous-mouse LD50 170 mg/kg LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948. intraperitoneal-mouse LD50 1364 mg/kg LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
preservatives
Recommendation for sodium citrate anhydrous usage levels up to:
	not for fragrance use.

Recommendation for sodium citrate anhydrous flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

ClinicalTrials.gov:search

NIOSH International Chemical Safety Cards:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):68-04-2

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :6224

National Institute of Allergy and Infectious Diseases:Data

trisodium 2-hydroxypropane-1,2,3-tricarboxylate

Chemidplus:0000068042

RTECS:68-04-2

References:

	trisodium 2-hydroxypropane-1,2,3-tricarboxylate
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	68-04-2
Pubchem (cid):	6224
Pubchem (sid):	134971042

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	D05855
HMDB (The Human Metabolome Database):	Search
FDA Listing of Food Additive Status:	View
Wikipedia:	View
Formulations/Preparations: •sodium citrate is an ingredient in anticoagulant citrate dextrose solution usp; anticoagulant citrate phosphate dextrose solution usp; & sodium citrate & citric acid solution usp. •grades: highest purity, medicinal; pure, commercial, cp; usp; fcc. dihydrate

Potential Blenders and core components note

None Found

Potential Uses:

	buffering agents
	chelating agents

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	citric acid trisodium salt
2-	hydroxy-1,2,3-propane tricarboxylic acid trisodium salt anhydrous
	natrocitral
	trisodium 2-hydroxy-1,2,3-propane tricarboxylate
	trisodium 2-hydroxypropane-1,2,3-tricarboxylate
	trisodium citrate

Articles:

PubMed:Effect of increasing the protein-to-fat ratio and reducing fat content on the chemical and physical properties of processed cheese product.

PubMed:Development of a multi-mycotoxin analysis in beer-based drinks by a modified QuEChERS method and ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.

PubMed:A multipathogen selective enrichment broth for simultaneous growth of Salmonella spp., Vibrio parahaemolyticus, and Vibrio cholerae.

PubMed:Casein peptization, functional properties, and sensory acceptance of processed cheese spreads made with different emulsifying salts.

PubMed:Rheological enhancement of mechanically activated alpha-tricalcium phosphate cements.

PubMed:Factors influencing calcium phosphate cement shelf-life.

PubMed:Ionic modification of calcium phosphate cement viscosity. Part II: hypodermic injection and strength improvement of brushite cement.

PubMed:Ionic modification of calcium phosphate cement viscosity. Part I: hypodermic injection and strength improvement of apatite cement.

PubMed:Effect of sodium citrate on structure-function relationships of Cheddar cheese.

PubMed:Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride.

PubMed:Chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms.

PubMed:The effects of a single evening dose of alkaline citrate on urine composition and calcium stone formation.

PubMed:The adsorption of 99mTc(Sn)-diphosphonate complexes on tri-calciumphosphate: the influence of preparation conditions, ligand-type, incubation media and adsorption conditions. The reversibility of the adsorption.

Notes:

a key intermediate in metabolism. it is an acid compound found in citrus fruits. the salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.

sodium citrate anhydrous citric acid trisodium salt

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sodium citrate anhydrous
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