EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isopropyl paraben
benzoic acid, 4-hydroxy-, 1-methylethyl ester (9CI)

Supplier Sponsors

CAS Number: 4191-73-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:224-069-3
FDA UNII:A6EOX47QK0
Nikkaji Web:J1.260B
Beilstein Number:2641564
MDL:MFCD00016468
XlogP3:2.80 (est)
Molecular Weight:180.20324000
Formula:C10 H12 O3
NMR Predictor:Predict (works with chrome or firefox)
Category:antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:4-hydroxybenzoic acid isopropyl ester
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 286.00 to 287.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.001000 mmHg @ 25.00 °C. (est)
Flash Point: 249.00 °F. TCC ( 120.40 °C. ) (est)
logP (o/w): 2.745 (est)
Soluble in:
 alcohol
 water, 689.7 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
BOC Sciences
For experimental / research use only.
Isopropyl paraben 98%
Odor: characteristic
Use: An antimicrobial
Matrix Scientific
For experimental / research use only.
isoPropyl 4-hydroxybenzoate
Nanjing Jiancheng Chemical
isoPropyl Paraben
Odor: characteristic
Use: Isopropyl paraben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives.
Penta International
ISOPROPYL-P-HYDROXY BENZOATE
Santa Cruz Biotechnology
For experimental / research use only.
isoPropyl Paraben
Sigma-Aldrich
For experimental / research use only.
isoPropyl 4-hydroxybenzoate analytical reference material
TCI AMERICA
For experimental / research use only.
isoPropyl 4-Hydroxybenzoate >99.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
subcutaneous-mouse LD50 1900 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antimicrobial agents
Recommendation for isopropyl paraben usage levels up to:
 not for fragrance use.
 
Recommendation for isopropyl paraben flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :20161
National Institute of Allergy and Infectious Diseases:Data
propan-2-yl 4-hydroxybenzoate
Chemidplus:0004191735
RTECS:DH2250000 for cas# 4191-73-5
 
References:
 propan-2-yl 4-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:4191-73-5
Pubchem (cid):20161
Pubchem (sid):134984920
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
KEGG (GenomeNet):C20343
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.29.7500
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzoic acid, 4-hydroxy-, 1-methylethyl ester (9CI)
 benzoic acid, 4-hydroxy-, isopropyl ester
 benzoic acid, p-hydroxy-, isopropyl ester
4-hydroxybenzoic acid isopropyl ester
p-hydroxybenzoic acid isopropyl ester
para-hydroxybenzoic acid isopropyl ester
4-hydroxybenzoic acid, 1-methylethyl ester
 methylethyl 4-hydroxybenzoate
1-methylethyl 4-hydroxybenzoate
 propan-2-yl 4-hydroxybenzoate
isopropyl 4-hydroxybenzoate
isopropyl p-hydroxybenzoate
isopropyl para-hydroxybenzoate
isopropyl-p-hydroxy benzoate
isopropylhydroxybenzoate
isopropylparaben
 

Articles:

PubMed:Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes.
PubMed:Assessment of the sensitizing potency of preservatives with chance of skin contact by the loose-fit coculture-based sensitization assay (LCSA).
PubMed:A multiclass method for the analysis of endocrine disrupting chemicals in human urine samples. Sample treatment by dispersive liquid-liquid microextraction.
PubMed:Drug-excipient compatibility studies in binary mixtures of avobenzone.
PubMed:The role of vehicle interactions on permeation of an active through model membranes and human skin.
PubMed:The influence of volatile solvents on transport across model membranes and human skin.
PubMed:Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells.
PubMed:Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding.
PubMed:Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455).
PubMed:[Effect of topical application of aminoguanidine cream on skin tissue of rats with diabetes].
PubMed:Estrogen receptor α is involved in the induction of Calbindin-D(9k) and progesterone receptor by parabens in GH3 cells: a biomarker gene for screening xenoestrogens.
PubMed:Preparation of monoliths from single crosslinking monomers for reversed-phase capillary chromatography of small molecules.
PubMed:Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods.
PubMed:Molecularly imprinted polymer for the extraction of parabens from environmental solid samples prior to their determination by high performance liquid chromatography-ultraviolet detection.
PubMed:Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.
PubMed:In vitro and in vivo evaluation of efficacy of citrate/methylene blue/parabens/IPA solution as a skin disinfectant.
PubMed:An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model.
PubMed:Probabilistic ecological hazard assessment of parabens using Daphnia magna and Pimephales promelas.
PubMed:Single-drop microextraction followed by in-syringe derivatization and GC-MS detection for the determination of parabens in water and cosmetic products.
PubMed:Determination of parabens in environmental solid samples by ultrasonic-assisted extraction and liquid chromatography with triple quadrupole mass spectrometry.
PubMed:Associations between baseline allergens and polysensitization.
PubMed:Association of nicotinamide with parabens: effect on solubility, partition and transdermal permeation.
PubMed:20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies.
PubMed:[Determination of six p-hydroxybenzoic acid esters in laver (nori) by HPLC].
PubMed:[Competitive binding of some alkyl p-hydroxybenzoates to human estrogen receptor alpha and beta].
PubMed:A simplified and rapid high-performance liquid chromatographic assay for ketoprofen in isopropyl myristate.
PubMed:Mechanism of p-hydroxybenzoate ester-induced mitochondrial dysfunction and cytotoxicity in isolated rat hepatocytes.
PubMed:[13-week subchronic oral toxicity study of isopropyl p-hydroxybenzoate in F344 rats].
PubMed:High-performance liquid chromatographic determination of six p-hydroxybenzoic acid esters in cosmetics using Sep-Pak florisil cartridges for sample pre-treatment.
PubMed:Drug migration into soft gelatin capsule shells and its effect on in-vitro availability.
PubMed:An in-vitro investigation of drug availability from lipophilic solutions.
PubMed:Treatment of psoriasis of the scalp with betamethasone 17, 21-dipropionate plus salicylic acid lotion ('Diprosalic').
 
Notes:
None found
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