EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isobutyl paraben
4-hydroxybenzoic acid, 2-methylpropyl ester

Supplier Sponsors

CAS Number: 4247-02-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:224-208-8
FDA UNII:0QQJ25X58G
Nikkaji Web:J909A
Beilstein Number:2642305
MDL:MFCD00020167
XlogP3:3.40 (est)
Molecular Weight:194.23018000
Formula:C11 H14 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 76.00 °C. @ 760.00 mm Hg
Boiling Point: 302.00 to 303.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.001000 mmHg @ 25.00 °C. (est)
Flash Point: 258.00 °F. TCC ( 125.40 °C. ) (est)
logP (o/w): 3.255 (est)
Soluble in:
 alcohol
 water, 223.7 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
BOC Sciences
For experimental / research use only.
Isobutyl 4-hydroxybenzoate
ECSA Chemicals
ISOBUTYL PARABEN
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
HallStar
CoSept(tm) IB
Odor: characteristic
Use: More than the many other parabens, CoSept IB provides strong antimicrobial action against fungi and yeast. It is used as a co-preservative with other CoSepts in order to increase the spectrum of activity. CoSept IB is among the least water-soluble of the parabens with global approval as cosmetic biocides. Like the other parabens, it is only effective at acidic pH. Usage levels range from 0.001 to 0.2%.
Kingyoung Bio Technical
Isobutyparaben
Kraft Chemical
isoButyl Paraben
Nanjing Jiancheng Chemical
isoButyl Paraben
Odor: characteristic
Use: Isobutyl Paraben is mainly used as antiseptics in cosmetics, food and medicine.Isobutyl Paraben is also can be used as feed preservatives and intermediates of organic synthesis.
Penta International
ISOBUTYL-P-HYDROXYBENZOATE
Santa Cruz Biotechnology
For experimental / research use only.
Isobutyl Paraben
Sigma-Aldrich: Aldrich
For experimental / research use only.
IsoButyl 4-hydroxybenzoate 97%
TCI AMERICA
For experimental / research use only.
isoButyl 4-Hydroxybenzoate [for Biochemical Research] >99.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
subcutaneous-mouse LD50 2600 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
 
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):4247-02-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :20240
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-methylpropyl 4-hydroxybenzoate
Chemidplus:0004247023
RTECS:DH2247000 for cas# 4247-02-3
 
References:
 2-methylpropyl 4-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:4247-02-3
Pubchem (cid):20240
Pubchem (sid):134986158
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):C20342
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2916.39.7900
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzoic acid, 4-hydroxy-, 2-methylpropyl ester (9CI)
 benzoic acid, p-hydroxy-, isobutyl ester
isobutyl 4-hydroxybenzoate
isobutyl p-hydroxybenzoate
isobutyl para-hydroxybenzoate
isobutyl parahydroxybenzoate
isobutyl-p-hydroxybenzoate
isobutylparaben
 cosept IB
4-hydroxybenzoic acid 2-methylpropyl ester
4-hydroxybenzoic acid isobutyl ester
p-hydroxybenzoic acid isobutyl ester
4-hydroxybenzoic acid isobutylester
4-hydroxybenzoic acid, 2-methylpropyl ester
2-methylpropyl 4-hydroxybenzoate
 

Articles:

PubMed:Additional effects of bisphenol A and paraben on the induction of calbindin-D(9K) and progesterone receptor via an estrogen receptor pathway in rat pituitary GH3 cells.
PubMed:Calbindin-D9k as a sensitive molecular biomarker for evaluating the synergistic impact of estrogenic chemicals on GH3 rat pituitary cells.
PubMed:Large volume sample stacking with EOF and sweeping in CE for determination of common preservatives in cosmetic products by chemometric experimental design.
PubMed:Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum.
PubMed:Synergistic effects of octylphenol and isobutyl paraben on the expression of calbindin-D₉k in GH3 rat pituitary cells.
PubMed:Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells.
PubMed:Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding.
PubMed:Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455).
PubMed:Maternal exposure to isobutyl-paraben impairs social recognition in adult female rats.
PubMed:In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay.
PubMed:Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.
PubMed:Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats.
PubMed:An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model.
PubMed:Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats.
PubMed:Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products.
PubMed:Removal of estrogenic activity of iso-butylparaben and n-butylparaben by laccase in the presence of 1-hydroxybenzotriazole.
PubMed:Parabens in male infertility-is there a mitochondrial connection?
PubMed:Construction of simplified models to simulate estrogenic disruptions by esters of 4-hydroxy benzoic acid (parabens).
PubMed:A review of the endocrine activity of parabens and implications for potential risks to human health.
PubMed:Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens.
PubMed:Oestrogenic activity of benzylparaben.
PubMed:Oestrogenic activity of isobutylparaben in vitro and in vivo.
PubMed:ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.
 
Notes:
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy