EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

DMDM hydantoin
hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-

Supplier Sponsors

CAS Number: 6440-58-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:229-222-8
FDA UNII:BYR0546TOW
Nikkaji Web:J207.046D
Beilstein Number:0882348
XlogP3-AA:-0.20 (est)
Molecular Weight:188.18344000
Formula:C7 H12 N2 O4
NMR Predictor:Predict (works with chrome or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):6440-58-0 ; 1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOIN
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 303.71 °C. @ 760.00 mm Hg (est)
Flash Point: 279.00 °F. TCC ( 137.50 °C. ) (est)
logP (o/w): -1.078 (est)
Soluble in:
 water, 2.612e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
Acme-Hardesty
DMDM Hydantoin
Odor: characteristic
Use: Antimicrobial Preservative Used in Personal Care Applications.
BOC Sciences
For experimental / research use only.
1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione 98%
Connect Chemicals
Dimethyl Dimethylhydantoin (DMDMH)
Kingyoung Bio Technical
DMDM Hydantoin
Kraft Chemical
DMDM Hydantoin
Nanjing Jiancheng Chemical
DMDM hydantoin (DMDMH)
Odor: characteristic
Use: DMDMH is widely used as antiseptic for its bactericidal effect. It can constrain the bacterium, yeast, mould, gram-positive bacterium and gram-negative bacterium. It can be applied in all kinds of cosmetics and Personal Care, such as shampoo, conditioner, cream, shower gel and so on.
Shiva Chemicals and Pharmaceuticals
Dimethyloldimethyl Hydantoin
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo 1320 mg/kg
Agricultural and Biological Chemistry. Vol. 40, Pg. 1705, 1976.

oral-mouse LDLo 3000 mg/kg
Agricultural and Biological Chemistry. Vol. 40, Pg. 1705, 1976.

oral-rat LD50 2000 mg/kg
LIVER: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of the American College of Toxicology. Vol. 7(3), Pg. 245, 1988.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for DMDM hydantoin usage levels up to:
 not for fragrance use.
 
Recommendation for DMDM hydantoin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):6440-58-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :22947
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
Chemidplus:0006440580
 
References:
 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:6440-58-0
Pubchem (cid):22947
Pubchem (sid):134987962
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB004274
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•dantogard active ingredient 32.0% dmdm hydantoin, 7.5% mdm hydantoin •dantogard plus industrial preservative active ingredient 4.5% 3-iodo-2-propynyl butylcarbamate, 87.0% dmdm hydantoin, 0.4% mdm hydantoin •dantogard xl-1000 95.5% dmdm hydantoin, 4.0% mdm hydantoin •dantogard ii preservative active ingredient 26.4% dmdm hydantoin, 23.2% mdm hydantoin •dantocil ig active ingredient 0.04% 5-chloro-2-methyl-3(2h)-isothiazolone, 0.01% 2-methyl-3(2h)-isothiazolone, 29.4% dmdm hydantoin, 27.9% mdm hydantoin •glycoserve active ingredient 45.0% dmdm hydantoin, 10.0% mdm hydantoin •troy 2063 active ingredient 8.0% 1,2-benzisothiazolin-3-one, 9.6% dmdm hydantoin, 2.2% mdm hydantoin •troysan 680 active ingredient 10.9% 1,2-benzisothiazolin-3-one, 12.5% dmdm hydantoin, 2.9% mdm hydantoin
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dantoin-DMDMH
1,3-di(hydroxymethyl)-5,5-dimethylhydantoin
1,3-dihydroxymethyl-5,5-dimethylhydantoin
1,3-dimethylol-5,5-dimethyl hydantoin
1,3-dimethylol-5,5-dimethyl-hydantoin
1,3-dimethylol-5,5-dimethylhydantion
 dimethylol-5,5-dimethylhydantoin
1,3-dimethylol-5,5-dimethylhydantoin
 dimethyloldimethyl hydantoin
 dimethyloldimethylhydantoin
 DMDMH
 glycoserve-DMDMH
 hydantoin
 hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
1,3-bis(hydroxymethyl)-5,5-dimethyl-1,3-diazolidine-2,4-dione
1,3-bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione
1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
2,4-imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
 mackstat DM
 

Articles:

PubMed:Preservatives in cosmetics in the Israeli market conform well to the EU legislation.
PubMed:Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives.
PubMed:Frequency of positive patch test reactions to preservatives: The Australian experience.
PubMed:Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers towards amino acids through breakdown products other than formaldehyde.
PubMed:Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms.
PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde.
PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics.
PubMed:Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II.
PubMed:Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group.
PubMed:[Contact allergy to preservatives contained in cosmetics].
PubMed:Contact sensitivity to preservatives in Turkey.
PubMed:[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
PubMed:Contact allergy from DMDM hydantoin, 1994-2000.
PubMed:Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group.
PubMed:Patch test reactivity to DMDM hydantoin. Relationship to formaldehyde allergy.
PubMed:Contact allergy to preservatives--II.
 
Notes:
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy