EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

diazolidinyl urea
1-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-1,3-bis(hydroxymethyl)urea

Supplier Sponsors

CAS Number: 78491-02-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:278-928-2
FDA UNII:N9VX1IBW6K
Nikkaji Web:J319.774C
MDL:MFCD03547942
XlogP3-AA:-2.50 (est)
Molecular Weight:278.22198000
Formula:C8 H14 N4 O7
NMR Predictor:Predict (works with chrome or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -5.398 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
BOC Sciences
For experimental / research use only.
Diazolidinyl urea
Odor: characteristic
Use: Diazolidinyl urea is an antimicrobial preservative used in cosmetics.
ECSA Chemicals
DIAZOLIDINYL UREA
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Kingyoung Bio Technical
Diazolidinyl Urea
Kraft Chemical
Diazolidinyl Urea USP/NF
Nanjing Jiancheng Chemical
Diazolidinyl Urea(Germall II)
Odor: characteristic
Use: Diazolidinyl urea is widely used as antiseptic for its bactericidal effect. It can constrain the bacterium, yeast, mould, gram-positive bacterium and gram-negative bacterium.It can be applied in cream, dew liquid, shampoo, hair conditioner, eye cosmetics, liquid cosmetics and other cosmetics.
Santa Cruz Biotechnology
For experimental / research use only.
Diazolidinyl Urea
Sigma-Aldrich: Aldrich
For experimental / research use only.
Diazolidinyl urea ≥95%
TCI AMERICA
For experimental / research use only.
Diazolidinyl Urea >98.0%(N)
TRI-K Industries
TRIstat D
Odor: characteristic
Use: A fine powder, highly soluble in water and effective against Gram positive and Gram negative bacteria.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 > 2250 mg/kg
Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 14, Pg. 3, 1995.

oral-mouse LD50 3573 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 14, Pg. 3, 1995.

oral-rat LD50 2600 mg/kg
Journal of the American College of Toxicology. Vol. 9(2), Pg. 229, 1990.

Dermal Toxicity:
skin-rabbit LD50 > 2000 mg/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 14, Pg. 3, 1995.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for diazolidinyl urea usage levels up to:
 not for fragrance use.
 
Recommendation for diazolidinyl urea flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):78491-02-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62277
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
Chemidplus:0078491028
RTECS:YS2717000 for cas# 78491-02-8
 
References:
 1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:78491-02-8
Pubchem (cid):62277
Pubchem (sid):135019701
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2941.90.5000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 diazolidinyl urea USP/NF
 diazolidinylurea
 germall 11
N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea
1-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-1,3-bis(hydroxymethyl)urea
N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)urea
N-[1,3-bis(hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]-N-(hydroxymethyl)[(h ydroxymethyl)amino]carboxamide
N-[1,3-bis(hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]-N-(hydroxymethyl)[(hydroxymethyl)amino]carboxamide
1-(1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1,3-bis(hydroxymethyl) urea
1-(1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1,3-bis(hydroxymethyl)urea
1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
N-(hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)urea
 urea, diazolidinyl
 urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)-
 urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-
 

Articles:

PubMed:The different decomposition properties of diazolidinyl urea in cosmetics and patch test materials.
PubMed:Hydrogel allergic contact dermatitis and imidazolidinyl urea/diazolidinyl urea.
PubMed:Allergic contact dermatitis in health care workers to diazolidinyl urea present in antimicrobial hand gel.
PubMed:Allergic contact dermatitis in a girl due to several cosmetics containing diazolidinyl-urea or imidazolidinyl-urea.
PubMed:Simultaneous measurement of diazolidinyl urea, urea, and allantoin in cosmetic samples by hydrophilic interaction chromatography.
PubMed:Contact allergy to diazolidinyl urea (Germall II).
PubMed:Experimental delayed contact sensitization to diazolidinyl urea (Germall II) in guinea pigs.
PubMed:Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials.
PubMed:Experimental elicitation of contact allergy from a diazolidinyl urea-preserved cream in relation to anatomical region, exposure time and concentration.
PubMed:Acute allergic contact dermatitis from diazolidinyl urea (Germall II) in a hair gel.
PubMed:Trends in patch-test results and allergen changes in the standard series: a Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010).
PubMed:ROAT: morphology of ROAT on arm, neck and face in formaldehyde and diazolidinyl urea sensitive individuals.
PubMed:Determination of diazolidinyl urea in a topical cream by high-performance liquid chromatography.
PubMed:Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance.
PubMed:Contact sensitivity to diazolidinyl urea (Germall II).
PubMed:Antimicrobial activities of N-chloramines and diazolidinyl urea.
PubMed:Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea.
PubMed:Effects of the formaldehyde releasing preservatives dimethylol urea and diazolidinyl urea in several short-term genotoxicity tests.
PubMed:Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches.
PubMed:Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009).
PubMed:[Allergy to diazolidinyl urea (Germall II) and imidazolidinyl urea (Germall 115)].
PubMed:Contact sensitization to diazolidinyl urea: report of 3 cases.
PubMed:Low-level efficacy of cosmetic preservatives.
PubMed:Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives.
PubMed:Patch Testing with Formaldehyde 2.0% in Parallel with 1.0% by the Swedish Contact Dermatitis Research Group.
PubMed:The relevance of 7-day patch test reading.
PubMed:North American Contact Dermatitis Group patch test results: 2009 to 2010.
PubMed:Frequency of positive patch test reactions to preservatives: The Australian experience.
PubMed:North American Contact Dermatitis Group patch test results for 2007-2008.
PubMed:[Contact sensitization to allergens in the Spanish standard series at Hospital Costa del Sol in Marbella, Spain: a retrospective study (2005-2010)].
PubMed:Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008.
PubMed:Formalehyde in personal care products.
PubMed:Non-fragrance allergens in specific cosmetic products.
PubMed:Contact allergy to preservatives. Analysis of IVDK data 1996-2009.
PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics.
PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde.
PubMed:Patch testing with preservatives at St John's from 1982 to 1993.
PubMed:Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema.
PubMed:Allergic contact dermatitis to preservatives in topical medicaments.
PubMed:A method for quantification of formaldehyde in the presence of formaldehyde donors in skin-care products.
PubMed:Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II.
PubMed:Contact sensitivity to preservatives in Turkey.
PubMed:The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance.
PubMed:Microbial inhibitors for U.S. EPA drinking water methods for the determination of organic compounds.
PubMed:A review of 79 cases of eyelid dermatitis.
PubMed:Formaldehyde in reusable protective gloves.
PubMed:Evaluation of phototoxic properties of antimicrobials used in topical preparations by a photohaemolysis test.
PubMed:[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
PubMed:Considerations necessary in gathering occurrence data for selected unstable compounds in the USEPA Unregulated Contaminant Candidate List in USEPA Method 526.
PubMed:Significance-prevalence index number: a reinterpretation and enhancement of data from the North American contact dermatitis group.
PubMed:Patch testing with preservatives, antimicrobials and industrial biocides. Results from a multicentre study.
PubMed:Influence of formulation on the in vitro transdermal penetration of flutrimazole.
PubMed:Detection of DNA-crosslinking agents with the alkaline comet assay.
 
Notes:
None found
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