EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tromethamine
methylamine, 1,1,1-tris(hydroxymethyl)-

Supplier Sponsors

Name:2-amino-2-(hydroxymethyl)propane-1,3-diol
CAS Number: 77-86-1Picture of molecule3D/inchi
Other(deleted CASRN):108195-86-4
ECHA EINECS - REACH Pre-Reg:201-064-4
FDA UNII:023C2WHX2V
Nikkaji Web:J4.214E
Beilstein Number:741883
MDL:MFCD00004679
XlogP3-AA:-2.90 (est)
Molecular Weight:121.13627000
Formula:C4 H11 N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:buffering agents and neutralizing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 171.00 to 172.00 °C. @ 760.00 mm Hg
Boiling Point: 357.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000001 mmHg @ 25.00 °C. (est)
Flash Point: 337.00 °F. TCC ( 169.70 °C. ) (est)
logP (o/w): -2.515 (est)
Soluble in:
 water, 550000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: buffering agents
fragrance
 
Suppliers:
BOC Sciences
For experimental / research use only.
Trometamol >98%
Odor: characteristic
Use: Trometamol is a proton acceptor used to treat acidemia.
Dow Chemical
TRIS AMINO™
ECSA Chemicals
TRIS (HYDROXYMETHYL)-AMINOMETHANE RPE-FOR AN
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
EMD Millipore
For experimental / research use only.
Tris(hydroxymethyl)aminomethane
Glentham Life Sciences
TRIS Ultrapure, 99.9%, Ph. Eur. grade
Glentham Life Sciences
TRIS
Santa Cruz Biotechnology
For experimental / research use only.
Tris base ≥99%
Sigma-Aldrich
For experimental / research use only.
Tris(hydroxymethyl)aminomethane ACS reagent, ≥99.8%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 5900 mg/kg
Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971.

intravenous-rat LD50 1800 mg/kg
Drugs in Japan Vol. -, Pg. 419, 1990.

intravenous-mouse LD50 1210 mg/kg
Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966.

oral-rabbit LDLo 1000 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
buffering agents and neutralizing agents
Recommendation for tromethamine usage levels up to:
 not for fragrance use.
 
Recommendation for tromethamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):77-86-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6503
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-amino-2-(hydroxymethyl)propane-1,3-diol
Chemidplus:0000077861
RTECS:TY2900000 for cas# 77-86-1
 
References:
 2-amino-2-(hydroxymethyl)propane-1,3-diol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:77-86-1
Pubchem (cid):6503
Pubchem (sid):134972802
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07182
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.19.5000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•tromethamine formulations: parenteral injection 36 mgml (18 g) tham, hospira. •tromethamine, nf (tham), is avail as 0.3 molar soln adjusted to ph 8.6 with acetic acid. it is also supplied as powder (tham-e) to be dissolved in 1 l of sterile water. each l contains 300 mmoles (36 g) of tromethamine, 30 mmoles of sodium chloride, & 5 mmoles of potassium chloride.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 buffering agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-amino-2-(hydroxymethyl)-1,3-propane diol
2-amino-2-(hydroxymethyl)-1,3-propanediol
2-amino-2-(hydroxymethyl)propan-1,3-diol
2-amino-2-(hydroxymethyl)propane-1,3-diol
2-amino-2-hydroxymethyl-1,3-propanediol
2-amino-2-hydroxymethylpropane-1,3-diol
2-amino-2-methylol-1,3-propanediol
 aminotris(hydroxymethyl)methane
tris(hydroxymethyl) aminomethane
2-(hydroxymethyl)-2-amino-1,3-propanediol
1,1,1-tris(hydroxymethyl)-methanamine
tris(hydroxymethyl)aminomethane ACS
1,1,1-tris(hydroxymethyl)methanamine
tris(hydroxymethyl)methanamine
1,1,1-tris(hydroxymethyl)methylamine
tris(hydroxymethyl)methylamine
tris(hydroxymethyly)amino methane
 methanamine, 1,1,1-tris(hydroxymethyl)-
 methylamine, 1,1,1-tris(hydroxymethyl)-
1,3-propanediol, 2-amino-2- (hydroxymethyl)-
1,3-propanediol, 2-amino-2-(hydroxymethyl)-
 tri(hydroxymethyl)aminomethane
 trimethylol aminomethane
 tris amino
 trometamol
 trometamole
 tromethamolum
 

Articles:

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PubMed:An assay for pro-oxidant reactivity based on phenoxyl radicals generated by laccase.
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PubMed:Solvent selection and optimization of α-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Tyr-NH2 using mixture design and response surface methodology.
PubMed:The effect of chilled storage and cryopreservation on the sperm DNA fragmentation dynamics of a captive population of koalas.
PubMed:Intranasal ketorolac (Sprix).
PubMed:Isolation of high quality RNA from cereal seeds containing high levels of starch.
PubMed:Characterization of the responses of equine digital veins and arteries to calcitonin gene-related peptide.
PubMed:Separation of dipeptides with two chiral centers using 2-hydroxypropyl-beta-CD-modified MEKC.
PubMed:Assay of bradykinin metabolites in human body fluids by CE-LIF coupled with transient ITP preconcentration.
PubMed:Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac.
PubMed:[Change of glucose transporter 4 and its influence on glucose and fatty-acid metabolism in type 2 diabetic myocardium].
PubMed:Analysis of organic acids and inorganic anions in beverage drinks by capillary electrophoresis.
PubMed:Process development for heme-enriched peptide by enzymatic hydrolysis of hemoglobin.
PubMed:A convenient one-step extraction of cellular ATP using boiling water for the luciferin-luciferase assay of ATP.
PubMed:Direct compression tablets containing a series of four beta-cyclodextrin complexes formed by neutralizing an acidic drug.
PubMed:Retrospective case-control evaluation of the use of parenteral ketorolac tromethamine in patients after surgery.
PubMed:The effect of food and an antacid on the bioavailability of dexketoprofen trometamol.
PubMed:Response of Salmonella choleraesuis LT2 spheroplasts and permeabilized cells to the bacteriocin AS-48.
PubMed:Comparative effects of ketorolac 0.5% or diclofenac 0.1% ophthalmic solutions on inflammation after cataract surgery.
PubMed:Single-dose treatment of acute cystitis with fosfomycin tromethamine.
PubMed:Prolonged central intravenous ketorolac continuous infusion in a cancer patient with intractable bone pain.
PubMed:New therapeutic agents marketed in 1993.
PubMed:New drugs from 1991-1992.
PubMed:Comparison of a prostaglandin-F2alpha-based reproductive program with an estrus detection-based reproductive program on a large commercial dairy herd.
PubMed:Management of low back pain by analgesics and adjuvant drugs.
PubMed:Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals.
PubMed:Relative bioavailability of fosfomycin and of trometamol after administration of single dose by oral route of fosfomycin trometamol in fasting conditions and after a meal.
PubMed:The general utility of a glycerophosphate-Tris buffered medium.
PubMed:Intra-amniotic administration of 15(S)-15-methyl-prostaglandin F2alpha for the induction of midtrimester abortion.
PubMed:Release of motilin in man.
PubMed:Chemicals bathing the oxyntic gland area stimulate acid secretion in dog.
PubMed:New drugs and new treatments.
 
Notes:
an organic amine proton acceptor. it is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (from merck, 11th ed; martindale, the extra pharmacopoeia, 30th ed, p1424)
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