EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

toluene
mono-methyl benzene

Supplier Sponsors

Fragrance Demo Formulas
CAS Number: 108-88-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-625-9
FDA UNII:3FPU23BG52
Nikkaji Web:J2.868A
Beilstein Number:0635760
MDL:MFCD00008512
XlogP3:2.70 (est)
Molecular Weight:92.14076000
Formula:C7 H8
NMR Predictor:Predict (works with chrome or firefox)
Category:extraction solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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JECFA Food Additive: Toluene
FDA Mainterm (SATF):108-88-3 ; toluene
FDA Mainterm (IAUFC):108-88-3 ; TOLUENE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart H--Other Specific Usage Additives
Sec. 172.736 Glycerides and polyglycides of hydrogenated vegetable oils.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.86500 @ 25.00 °C.
Melting Point: -95.00 to -94.00 °C. @ 760.00 mm Hg
Boiling Point: 110.00 to 111.00 °C. @ 760.00 mm Hg
Boiling Point: 36.00 to 37.00 °C. @ 50.00 mm Hg
Vapor Pressure:27.712000 mmHg @ 25.00 °C. (est)
Vapor Density:3.2 ( Air = 1 )
Flash Point: 39.00 °F. TCC ( 3.89 °C. )
logP (o/w): 2.730
Soluble in:
 alcohol
 water, 573.1 mg/L @ 25 °C (est)
 water, 526 mg/L @ 25 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Description:at 10.00 %. sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
solvents
 
Suppliers:
Charkit Chemical
TOLUENE
Chevron Phillips
Toluene, Reference Fuel Grade
Covalent Chemical
Toluene
ECSA Chemicals
MIXTURE 90% TOLUENE - 10% IPA
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
TOLUENE PURE
ECSA Chemicals
TOLUENE RE-PURE, ML 2500
ECSA Chemicals
TOLUENE REGENERATED
ECSA Chemicals
TOLUENE RS-FOR HPLC-ISOCRATIC GRADE, ML 2500
EMD Millipore
For experimental / research use only.
Toluene
Glentham Life Sciences
Toluene, anhydrous, 99.9%
Glentham Life Sciences
Toluene
Kraft Chemical
Toluene
LyondellBasell Industries
TOLUENE
Sigma-Aldrich
For experimental / research use only.
Toluene anhydrous, 99.8%
Silver Fern Chemical
Toluene
Odor: characteristic
Use: Toluene has many uses including fuels and gasoline, solvents for paints and coatings, resins, rubbers, oils, adhesives, and as a heat transfer fluid.
Wedor Corporation
TOLUENE
 
Safety Information:
European information :
Most important hazard(s):
Xn - Harmful.
R 11 - Highly flammable.
R 20 - Harmful by inhalation.
R 38 - Irritating to skin.
R 48 - Danger of serious damage to health by prolonged exposure.
R 63 - Possible risk of harm to the unborn child.
R 65 - Harmful: may cause lung damage if swallowed.
R 67 - Vapours may cause frowsiness and dizziness.
S 01/02 - Keep locked up and out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37 - Wear suitable protective clothing and gloves.
S 46 - If swallowed, seek medical advice immediately and show this container or label.
S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 636 mg/kg
Neurotoxicology. Vol. 2, Pg. 567, 1981.

intravenous-rat LD50 1960 mg/kg
Medicina del Lavoro. Industrial Medicine. Vol. 54, Pg. 486, 1963.

intraperitoneal-rat LD50 1332 mg/kg
Environmental Research. Vol. 40, Pg. 411, 1986.

intraperitoneal-guinea pig LD50 500 mg/kg
Neurotoxicology. Vol. 2, Pg. 567, 1981.

oral-human LDLo 50 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 883, 1980.

oral-mammal (species unspecified) LD50 4000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.

intraperitoneal-mammal (species unspecified) LDLo 1750 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
American Journal of Hygiene. Vol. 7, Pg. 276, 1927.

oral-man LDLo 719 uL/kg
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES CARDIAC: OTHER CHANGES
Forensic Science International. Vol. 41, Pg. 255, 1989.

intraperitoneal-mouse LD50 59 mg/kg
Neurotoxicology. Vol. 2, Pg. 567, 1981.

unreported-mouse LD50 2000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(12), Pg. 64, 1980.

intravenous-rabbit LDLo 130 mg/kg
Haematologica. Vol. 58, Pg. 491, 1973.

unreported-rat LD50 6900 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(12), Pg. 64, 1980.

Dermal Toxicity:
skin-rabbit LD50 14100 ul/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

subcutaneous-frog LDLo 920 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 130, Pg. 250, 1928.

subcutaneous-mouse LD50 2250 mg/kg
Neurotoxicology. Vol. 8, Pg. 237, 1987.

Inhalation Toxicity:
inhalation-rat LC50 49000 mg/m3/4H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 23, 1988.

inhalation-rabbit LC50 55000 ppm/40M
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 69, 1944.

inhalation-guinea pig LCLo 1600 ppm
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: IRRITABILITY
Journal of Industrial Hygiene. Vol. 10, Pg. 261, 1928.

inhalation-human TCLo 200 ppm
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE BEHAVIORAL: ANTIPSYCHOTIC BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
JAMA, Journal of the American Medical Association. Vol. 123, Pg. 1106, 1943.

inhalation-mammal (species unspecified) LC50 30000 mg/m3
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.

inhalation-man TCLo 100 ppm
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
Work, Environment, Health. Vol. 9, Pg. 131, 1972.

inhalation-mouse LC50 400 ppm/24H
Neurotoxicology. Vol. 2, Pg. 567, 1981.

inhalation-rabbit LCLo 55000 ppm/40M
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 69, 1944.

 
Safety in Use Information:
Category:
extraction solvents
IFRA Critical Effect:
Liver toxicity
IFRA fragrance material specification:
 The level of toluene has to be kept as low as practicable and should never exceed 100 ppm in the fragrance compound.
 View the IFRA Standard
Recommendation for toluene usage levels up to:
 PROHIBITED: Should not be used as a fragrance ingredient.
 
Recommendation for toluene flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ECHA (ESR):View
EPA-Iris:IRIS
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):108-88-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1140
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WISER:UN 1294
WGK Germany:2
toluene
Chemidplus:0000108883
EPA/NOAA CAMEO:hazardous materials
RTECS:108-88-3
 
References:
 toluene
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:108-88-3
Pubchem (cid):1140
Pubchem (sid):134973333
Flavornet:108-88-3
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C01455
HMDB (The Human Metabolome Database):HMDB34168
FooDB:FDB012454
Export Tariff Code:2902.30.0000
FDA Listing of Food Additive Status:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•research, reagent, nitration - all 99.8+%; industrial: contains 94+%, with 5% xylene and small amounts of benzene and nonaromatic hydrocarbons; 90120: less pure than industrial. •grades: research 99.99%; pure 99.98% •grades: 1st degree nitration; 2nd degree commercial; 90% solvent •grade: (usually defined in terms of boiling ranges) pure, commercial, straw-colored, nitration, scintilation, industrial.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 solvents
 
Occurrence (nature, food, other):note
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 chu-lan tree
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 coriander leaf
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 dianthus arenarius
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 dill shoot oil
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 dill weed oil cuba @ trace%
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 dill weed oil reunion @ 0.20%
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 eriotheca longitubulosa
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 guava fruit
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 kiwi fruit
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 kohlrabi stem
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 lavender oil spike spain @ 0.003%
Data GC Search Trop Picture
 mushroom giant puffball mushroom
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 myroxylon balsamum
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 osmanthus absolute @ trace%
Data GC Search Trop Picture
 papaya fruit
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 parsley leaf
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 pepper bell pepper fruit
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 petitgrain sweet oil @ 0.08%
Data GC Search Picture
 rosemary plant
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 spearmint oil
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 walnut black walnut fruit
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 walnut black walnut oil
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Synonyms:
 methacide
 methyl benzene
mono-methyl benzene
 methyl benzol
 phenyl methane
 tolu-sol
 toluene [UN1294] [Flammable liquid]
 toluol
 
 
Notes:
a widely used industrial solvent. Isol. from distilled tolu balsam (Myroxylon balsamum). Minor constit. of lime oil (Citrus aurantifolia) Toluene, formerly known as toluol, is a clear, water-insoluble liquid with the typical smell of paint thinners. It is an aromatic hydrocarbon that is widely used as an industrial feedstock and as a solvent. (Wikipedia)
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