EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

polyvinyl pyrrolidone
poly(1-vinylpyrrolidinone)

Supplier Sponsors

CAS Number: 9003-39-8
FDA UNII: FZ989GH94E
MDL:MFCD00149016
Formula:(C6 H9 N O)x-
Category:clarifying agents, stabilizers, bodying agents, tableting adjuncts, dispersing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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PubMed:Search
NCBI:Search
JECFA Food Additive: Polyvinylpyrrolidone
GSFA Codex: Polyvinylpyrrolidone (1201)
DG SANTE Food Additives:polyvinylpyrrolidone
DG SANTE Food Contact Materials:polyvinylpyrrolidone
FDA Mainterm (SATF):9003-39-8 ; POLYVINYLPYRROLIDONE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart C--Coatings, Films and Related Substances
Sec. 172.210 Coatings on fresh citrus fruit.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart A--Polymer Substances and Polymer Adjuvants for Food Treatment
Sec. 173.55 Polyvinylpyrrolidone.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.1 Diluents in color additive mixtures for food use exempt from certification.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart B--Drugs
Sec. 73.1001 Diluents in color additive mixtures for drug use exempt from certification.
 
Physical Properties:
Appearance:white to tan powder (est)
Food Chemicals Codex Listed: No
Soluble in:
 water
 alcohol
 chloroform
 water, 42.97 mg/L @ 25 °C (est)
Insoluble in:
 ether
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
binding agents
emulsion stabilisers
film formers
hair fixing agents
viscosity controlling agents
 
Suppliers:
Allan Chemical
Polyvinylpyrrolidone K 30
American International Chemical, LLC.
POLYVINYL PYRROLIDONE K-30 POWDER
American International Chemical, LLC.
Povidone
BASF
N-Vinyl-2-pyrrolidone
BOC Sciences
For experimental / research use only.
Crospovidone
Odor: characteristic
Use: Crospovidone is used as a drug excipient in drug formulations.
Charkit Chemical
POLYVINYL PYRROLIDONE K15
Charkit Chemical
POLYVINYL PYRROLIDONE K30
ECSA Chemicals
PVP K30 POWDER
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
PVP K90 POWDER
Glentham Life Sciences
Povidone K30
Indis NV
For experimental / research use only.
Polyvinylpyrrolidone - Various types
Jarchem Industries
Jarfilter™ 10
Jarchem Industries
Jarfilter™ F
Jarchem Industries
Jarfilter™ R
Jarchem Industries
Jarfilter™ V
Jarchem Industries
Jarfilter™ VT
Jarchem Industries
Jarpol™ PVP K30 Powder
Jarchem Industries
Jarpol™ PVP K30 Solution
Jarchem Industries
Jarpol™ PVP K90 Powder
Jarchem Industries
Jarpol™ PVP K90 Solution
Kraft Chemical
Polyvinylpyrrolidone
OQEMA
LanCos PVP-K30/100
Penta International
POVIDONE USP
Sigma-Aldrich
For experimental / research use only.
Polyvinylpyrrolidone average mol wt 40,000
Silver Fern Chemical
Polyvinylpyrrolidone (PVP)
Odor: characteristic
Use: Polyvinylpyrrolidone has many uses in industries including pharmaceuticals, glass, metals, plastics, cosmetics, dyes, textiles, detergents, adhesives, and beer and wine.
Universal Preserv-A-Chem Inc.
POLYVINYLPYRROLIDONE [PVP]
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 100000 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 486, 1974.

oral-rabbit LD50 1040 mg/kg
Veterinariya. Veterinary Science. Vol. 61(12), Pg. 68, 1985.

oral-guinea pig LD50 100000 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 486, 1974.

intraperitoneal-mouse LD50 12000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 486, 1974.

oral-mouse LD50 > 40000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 40, Pg. 164, 1967.

unreported-mouse LD50 16000 mg/kg
Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 19, Pg. 212, 1985.

oral-mouse LDLo 3000 mg/kg
Biomaterials, Medical Devices, and Artificial Organs. Vol. 12, Pg. 1, 1984.

oral-mouse LDLo 5000 mg/kg
Biomaterials, Medical Devices, and Artificial Organs. Vol. 12, Pg. 1, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
clarifying agents, stabilizers, bodying agents, tableting adjuncts, dispersing agents
Recommendation for polyvinyl pyrrolidone usage levels up to:
 not for fragrance use.
 
Recommendation for polyvinyl pyrrolidone flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to the 12th list of substances for food contact materials
View page or View pdf

Re-evaluation of polyvinylpyrrolidone (E 1201) and polyvinylpolypyrrolidone (E 1202) as food additives and extension of use of polyvinylpyrrolidone (E 1201)
View page or View pdf

EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9003-39-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0009003398
EPA/NOAA CAMEO:hazardous materials
RTECS:TR8370000 for cas# 9003-39-8
 
References:
Canada Domestic Sub. List:9003-39-8
Pubchem (sid):134989047
 
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):HMDB33843
FooDB:FDB012017
Export Tariff Code:3905.90.5000
FDA Listing of Food Additive Status:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antistatic agents
 binding agents
 emulsion stabilisers
 film formers
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 crospovidone NF
 crospovidone NF CPVSC7
1-ethenyl-2-pyrrolidinone homopolymer
1-ethenyl-2-pyrrolidinone polymers
1-ethenyl-2-pyrrolidinone, homopolymer
 jarfilter 10
 jarfilter F
 jarfilter R
 jarfilter V
 jarfilter VT
 jarpol PVP K30 powder
 jarpol PVP K30 solution
 jarpol PVP K90 powder
 jarpol PVP K90 solution
 poly-N-vinyl pyrrolidone
 poly(1-ethenyl-2-pyrrolidinone)
 poly(1-vinyl-2-pyrrolidinone)
 poly(1-vinyl-2-pyrrolidinone) homopolymer
 poly(1-vinyl-2-pyrrolidone)
 poly(1-vinylpyrrolidinone)
 poly(N-vinyl-2-pyrrolidinone)
 poly(N-vinyl-2-pyrrolidone)
 poly(N-vinylbutyrolactam)
 poly(N-vinylpyrrolidinone)
 poly(N-vinylpyrrolidone)
 poly(vinylpyrrolidinone)
 polyvinylpyrrolidone
 povidone
 povidone USP
 PVP
2-pyrrolidinone, 1-ethenyl, homopolymer
2-pyrrolidinone, 1-vinyl-, polymers
 sunlydone K-30
 sunvidone CL-100
 sunvidone CL-30
1-vinyl-2-pyrrolidinone homopolymer
1-vinyl-2-pyrrolidinone polymer
 vinyl-2-pyrrolidone polymer
1-vinyl-2-pyrrolidone polymer
N-vinyl-2-pyrrolidone polymer
N-vinylbutyrolactam polymer
N-vinylpyrrolidinone polymer
N-vinylpyrrolidone polymer
 

Articles:

PubMed:[Modern polymers in matrix tablets technology].
PubMed:Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles.
PubMed:Effect of the hand antiseptic agents benzalkonium chloride, povidone-iodine, ethanol, and chlorhexidine gluconate on atopic dermatitis in NC/Nga mice.
PubMed:Prospective evaluation of 2% (w/v) alcoholic chlorhexidine gluconate as an antiseptic agent for blood donor arm preparation.
PubMed:Does water chemistry affect the dietary uptake and toxicity of silver nanoparticles by the freshwater snail Lymnaea stagnalis?
PubMed:Effects of food colouring added to 2% chlorhexidine gluconate and 70% alcohol for surgical site antisepsis.
PubMed:Impact of pH on the stability and the cross-reactivity of ochratoxin A and citrinin.
PubMed:Back to the roots: photodynamic inactivation of bacteria based on water-soluble curcumin bound to polyvinylpyrrolidone as a photosensitizer.
PubMed:Betadine and breast implants: an update.
PubMed:Study on the electrochemical catalytic properties of the topological insulator Bi₂Se₃.
PubMed:Effect of inert gas and prefermentative treatment with polyvinylpolypyrrolidone on the phenolic composition of Chilean Sauvignon blanc wines.
PubMed:Electrospun drug-loaded core-sheath PVP/zein nanofibers for biphasic drug release.
PubMed:The influence of fining agents on the removal of some pesticides from white wine of Vitis vinifera L. cv. Emir.
PubMed:Selective melamine detection in multiple sample matrices with a portable Raman instrument using surface enhanced Raman spectroscopy-active gold nanoparticles.
PubMed:Production, recovery and purification of a recombinant β-galactosidase by expanded bed anion exchange adsorption.
PubMed:Comparison of in vitro methods of measuring mucoadhesion: ellipsometry, tensile strength and rheological measurements.
PubMed:Polyvinylpyrrolidone storage disease presenting as pathologic fracture and anemia: report of a case with imprint cytology.
PubMed:A meta-analysis of the published literature on the effectiveness of antimicrobial soaps.
PubMed:In vitro maturation supplements affect developmental competence of bovine cumulus-oocyte complexes and embryo quality after vitrification.
PubMed:Subacute oral toxicity investigation of nanoparticulate and ionic silver in rats.
PubMed:Accumulation of silver nanoparticles by cultured primary brain astrocytes.
PubMed:Specific immunoreaction-induced controlled release strategy for sensitive impedance immunoassay of a cancer marker.
PubMed:Extraction, partial characterization, and storage stability of β-glucosidase from propolis.
PubMed:Anesthesia in the patient with multiple drug allergies: are all allergies the same?
PubMed:Adsorption behavior of the catechins and caffeine onto polyvinylpolypyrrolidone.
PubMed:Lipoic acid nanoparticles: effect of polymeric stabilizer on appetite suppression.
PubMed:Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans.
PubMed:Successful Intervention for Pressure Ulcer by Nutrition Support Team: A Case Report.
PubMed:Analysis and chemistry of migrants from wine fining polymers.
PubMed:Influence of formulation and processing factors on stability of levothyroxine sodium pentahydrate.
PubMed:Evaporation influences on the crystallization of an aqueous dihydrate cupric chloride solution with additives.
PubMed:Synthetic receptors for selectively detecting erythrocyte ABO subgroups.
PubMed:A method for benzoyl chloride derivatization of biogenic amines for high performance liquid chromatography.
PubMed:A comparison of methods for preparing enriched populations of bovine spermatogonia.
PubMed:[Anaphylactic shock to iodinated povidone].
PubMed:Glycidyl methacrylate-co-N-vinyl-2-pyrrolidone coated polypropylene strips: synthesis, characterization and standardization for dot-enzyme linked immunosorbent assay.
PubMed:Plasticizers in the manufacture of novel skin-bioadhesive patches.
PubMed:Analysis of several methods for the extraction of high quality DNA from acetic acid bacteria in wine and vinegar for characterization by PCR-based methods.
PubMed:Evaluation of the umami taste intensity of green tea by a taste sensor.
PubMed:Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients.
PubMed:Removal of pesticides from white wine by the use of fining agents and filtration.
PubMed:A review of anti-septic agents for pre-operative skin preparation.
PubMed:The role of betadine irrigation in breast augmentation.
PubMed:Arsenic adsorption by polyvinyl pyrrolidone K25 coated cassava peel carbon from aqueous solution.
PubMed:Removal of famoxadone, fluquinconazole and trifloxystrobin residues in red wines: effects of clarification and filtration processes.
PubMed:The role of betadine irrigation in breast augmentation.
PubMed:Removal of high phenol concentrations with adapted activated sludge in suspended form and entrapped in calcium alginate /cross-linked poly(N-vinyl pyrrolidone) hydrogels.
PubMed:Comparison of two alcohol-based surgical scrub solutions with an iodine-based scrub brush for presurgical antiseptic effectiveness in a community hospital.
PubMed:Analysis of acrylamide in green tea by gas chromatography-mass spectrometry.
PubMed:[Iodine-induced goiter].
PubMed:PVPP-polyphenol complexes: a molecular approach.
PubMed:Combination povidone-iodine and alcohol formulations more effective, more convenient versus formulations containing either iodine or alcohol alone: a review of the literature.
PubMed:Development of two enzyme-linked immunosorbent assays for detection of endosulfan residues in agricultural products.
PubMed:Ibuprofen extrudate, a novel, rapidly dissolving ibuprofen formulation: relative bioavailability compared to ibuprofen lysinate and regular ibuprofen, and food effect on all formulations.
PubMed:Effects of clarification and filtration processes on the removal of fungicide residues in red wines (var. Monastrell).
PubMed:Anaphylaxis to povidone in a child.
PubMed:Maillard reaction rate in various glassy matrices.
PubMed:Effect of povidone iodine on silicone gel breast implants in vitro: implications for clinical practice.
PubMed:Carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs.
PubMed:Effect of povidone-iodine on Streptococcus mutans in children with extensive dental caries.
PubMed:A systems approach to preoperative surgical patient skin preparation.
PubMed:Properties of wheat bran polyphenol oxidase.
PubMed:Nonenzymatic browning in food models in the vicinity of the glass transition: effects of fructose, glucose, and xylose as reducing sugar.
PubMed:Mechanical analysis of explanted saline-filled breast implants exposed to betadine pocket irrigation.
PubMed:Characterization of haze-active proteins in apple juice.
PubMed:Controlled release of water-soluble polymeric complexes of sorbic acid with antifungal activities.
PubMed:Lipid dynamics in the plasma membrane of ram and bull spermatozoa after washing and exposure to macromolecules BSA and PVP.
PubMed:Optimizing breast-pocket irrigation: the post-betadine era.
PubMed:Structure and dry binding activity of different polymers, including Kollidon VA 64.
PubMed:Different methods for extracting bacteria from freshwater sediment and a simple method to measure bacterial production in sediment samples.
PubMed:Fractionation of cells and subcellular particles with Percoll.
PubMed:Improved PCR detection of Campylobacter jejuni from chicken rinses by a simple sample preparation procedure.
PubMed:The efficacy of three common hospital liquid germicides to inactivate Cryptosporidium parvum oocysts.
PubMed:Rapid analysis of methylated xanthines in teas by an improved high-performance liquid chromatographic method using a polyvinylpolypyrroridone pre-column.
PubMed:Deactivation of mycotoxins. I. An in vitro study of zearalenone adsorption on new polymeric adsorbents.
PubMed:Effect of tannin-binding agents, with or without enzyme supplementation, on the dry matter digestibility and ME of faba beans.
PubMed:Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application.
PubMed:Effects of polyvinylpolypyrrolidone, synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis.
PubMed:Iodine, thyroid function, and very low birth weight infants.
PubMed:Iatrogenic iodine toxicity.
PubMed:Anaphylactic shock following povidone.
PubMed:Heterologous protein secretion by Aspergillus niger growing in submerged culture as dispersed or aggregated mycelia.
PubMed:[A study on the establishment of the specification of polyvinylpolypyrroridone as a food additive].
PubMed:Excision of the distal sesamoid bone for treatment of infection of the digit in a heifer.
PubMed:Iodine supplementation in children receiving long-term parenteral nutrition.
PubMed:Human stools as a source of viable colonic epithelial cells.
PubMed:[Comparative effectiveness of the use of enterodes in acute allergic syndromes in children].
PubMed:[Use of enterodes in the treatment of patients with food poisoning].
PubMed:Disposition of [14C]povidone after oral administration to the rat.
PubMed:Liquid chromatographic analysis of enviradene, a new antiviral agent, in plasma and its application in bioavailability studies in the dog.
PubMed:[Effectiveness of the preparation "Enterodez" in acute intestinal infections].
PubMed:Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action.
PubMed:The tampon: investigated and challenged.
PubMed:[Effect of quartasol, trisol and hemodes on microcirculation in food poisoning].
PubMed:[Disorders of microcirculation in food poisoning].
PubMed:[Development of a method of concentrating enteroviruses for virologic studies of meat].
PubMed:Gastric emptying and small intestinal propulsion in fed and fasted rats.
PubMed:The effect of diet on the time of intestinal macromolecule absorption in the new-born rat.
PubMed:[Value of etiotropic, immunostimulating and pathogenetic therapy of typhoid fever, food poisoning (salmonellosis) and acute dysentery].
PubMed:Effect of various agents in alleviating the toxicity of tannic acid for chickens.
PubMed:[Methods of treating food poisoning using Polosukhin's solution and polyvinylpyrrolidone preparations].
PubMed:[On the deintoxicating action of polyvinylpyrrolidone in burns and food poisoning].
PubMed:BRONCHIAL ASTHMA DUE TO SOYBEAN ALLERGY: REPORT OF A CASE WITH AUDIOVISUAL DOCUMENTATION.
PubMed:Polyethylene glycols-tannins interaction in extracting enzymes.
PubMed:THE EFFECTS OF HAIR LACQUER SPRAYS ON THE LUNGS.
PubMed:[SYNDROME OF DEFECTIVE INTESTINAL ABSORPTION IN THE CHILD. (CELIAC SYNDROME)].
 
Notes:
a polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. Used as a diluent in colour additive mixtures for marking food; in coatings on fresh citrus fruits; as a clarifying agent for beer, wine and vinegar; as a tableting adjuvant A cross-linked form of PVP is also used as a disintegrant (see also excipients) in pharmaceutical tablets. It is also known as cross-linked polyvinyl pyrrolidone, Polyvinyl Polypyrrolidone (PVPP), crospovidone, crospolividone. Basically, PVPP is a highly cross-linked version of PVP, which makes it insoluble in water but it still absorbs water and swells very rapidly and generate a swelling force. That is why it can be used a disintegrant in tablets. It is also used to bind impurities to remove them from solutions.It is also used as a fining to extract impurities (via agglomeration followed by filtration). Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced. PVPP can be used as well as a drug taken as a tablet or suspension and it absorbs compounds (so called Endotoxins) causing diarrhoea. (Cf. bone char, charcoal.); As a food additive, PVP is a stabilizer and has E number E1201. PVPP is E1202. It is also used in the wine industry as a fining agent for white wine. Other references state that as polyvinyl pyrrolidone and its derivatives are fully from mineral synthetic origin. Therefore, its use in the production should not be a problem for vegans.; PVP is soluble in water and other polar solvents. In water it has the useful property of Newtonian viscosity. When dry it is a light flaky powder, which readily absorbs up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.; PVP was first synthesized by Prof. Walter Reppe and a patent was filed in 1939 for one of the most interesting derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.; Polyvinylpolypyrrolidone (PVPP, crospovidone) is a highly cross-linked modification of PVP.; Polyvinylpyrrolidone (PVP) is a water-soluble polymer made from the monomer N-vinylpyrrolidone:
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