|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 183.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 597.00 to 598.00 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 410.00 °F. TCC ( 210.20 °C. ) (est)
|
| logP (o/w): | 2.010 |
| Soluble in: |
| | water, 154.9 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-rat LD50 8.70 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948.
intraperitoneal-rat LD50 15 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: NAUSEA OR VOMITING
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948.
intravenous-rabbit LD50 5 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
SKIN AND APPENDAGES (SKIN): CUTANEOUS SENSITIZATION (EXPERIMENTAL): AFTER TOPICAL EXPOSURE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948.
oral-mouse LD50 100 mg/kg
PCT Vol. #86-04062
intravenous-mouse LD50 56 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01679
intraperitoneal-mouse LD50 30 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 327, 1961.
intramuscular-cat LD50 4 mg/kg
SKIN AND APPENDAGES (SKIN): CUTANEOUS SENSITIZATION (EXPERIMENTAL): AFTER TOPICAL EXPOSURE
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948.
intravenous-cat LD50 1700 ug/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948.
parenteral-frog LDLo 152 mg/kg
BEHAVIORAL: STIFFNESS
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891.
intramuscular-rat LD50 3 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: NAUSEA OR VOMITING
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948.
intravenous-rat LD50 8700 ug/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 249, 1948.
|
| Dermal Toxicity: |
subcutaneous-rat LD50 8 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
skin-rat LD50 500 mg/kg
PCT Vol. #86-04062
skin-rabbit LD50 200 mg/kg
PCT Vol. #86-04062
subcutaneous-cat LDLo 300 ug/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891.
subcutaneous-chicken LDLo 6250 ug/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891.
subcutaneous-dog LDLo 1 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 32, 1891.
subcutaneous-mouse LDLo 24600 ug/kg
Toxicon. Vol. 8, Pg. 85, 1970.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for podophyllotoxin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for podophyllotoxin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :10607 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one |
| Chemidplus:0000518285 |
| RTECS:LV2500000 for cas# 518-28-5 |
References:
| | (5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10607 |
| Pubchem (sid): | 134976487 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | condyline | | | condylox | | (10R,11R,15R,16R)-16- | hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1(9),2,7-trien-12-one | | (5R,5aR,8aR,9R)-9- | hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one | | (5R,5aR,8aR,9R)-9- | hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one | | (5R,5aR,8aR,9R)-9- | hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one | | (5R,9R,5aR,8aR)-9- | hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,9,5a,8a-pentahydro-2H-isobenzofurano[5',6'-2,1]benzo[4,5-d]1,3-dioxolan-6-one | | (5R,5aR,8aR,9R)-5- | hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one | | | podofilox | | | podophilox | | | podophyllinic acid lactone | | | podophyllotoxin (8CI) | | | podophyllotoxin 7 | | (5R,5aR,8aR,9R)-5,8,8a,9- | tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one | | (5R,5aR,8aR,9R)-5,8,8a,9- | tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one | | (5R,5aR,8aR,9R)-5,8,8a,9- | tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one | | [5R-(5a,5ab,8aa,9a)]-5,8,8a,9- | tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one | | | warticon |
Articles:
| PubMed:Podophyllotoxin and 6-methoxy podophyllotoxin Production in Hairy Root Cultures of Liunm mucronatum ssp. mucronatum. |
| PubMed:Stereoselective synthesis of 2α-Chloropicropodophyllotoxins and insecticidal activity of their esters against oriental armyworm, Mythimna separata walker. |
| PubMed:Synthesis of novel 4α-(acyloxy)-2'(2',6')-(di)halogenopodophyllotoxin derivatives as insecticidal agents. |
| PubMed:Production of podophyllotoxin from roots and plantlets of Hyptis suaveolens cultivated in vitro. |
| PubMed:Synthesis and insecticidal activity of new deoxypodophyllotoxin-based phenazine analogues against Mythimna separata Walker. |
| PubMed:Synthesis and quantitative structure-activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents. |
| PubMed:Synthesis and quantitative structure-activity relationship (QSAR) study of novel isoxazoline and oxime derivatives of podophyllotoxin as insecticidal agents. |
| PubMed:Podophyllotoxin and deoxypodophyllotoxin in Juniperus bermudiana and 12 other Juniperus species: optimization of extraction, method validation, and quantification. |
| PubMed:Seasonal variations in the deoxypodophyllotoxin content and yield of Anthriscus sylvestris L. (Hoffm.) grown in the field and under controlled conditions. |
| PubMed:Plant-derived bioactive compounds produced by endophytic fungi. |
| PubMed:Warts (genital). |
| PubMed:Semisynthesis and quantitative structure-activity relationship (QSAR) study of novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin as insecticidal agents. |
| PubMed:Modulation of gamma radiation-inflicted damage in Swiss albino mice by an alcoholic fraction of Podophyllum hexandrum rhizome. |
| PubMed:Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry. |
| PubMed:Warts (genital). |
| PubMed:Frequency and timing of leaf removal affect growth and podophyllotoxin content of Podophyllum peltatum in full sun. |
| PubMed:Biologically active components against Drosophila melanogaster from Podophyllum hexandrum. |
| PubMed:Mandrake toxicity. A case of mistaken identity. |
| PubMed:Human papillomavirus infection and genital warts: update on epidemiology and treatment. |
| PubMed:The effect of food and concurrent chemotherapy on the bioavailability of oral etoposide. |
| PubMed:Etoposide: a semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent. |
| PubMed:Review of etoposide. |
|
3D/inchi