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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 78.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 383.90 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 392.00 °F. TCC ( 200.20 °C. ) (est)
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| logP (o/w): | 2.450 (est) |
| Soluble in: |
| | water, 300 mg/L @ 15 °C (exp) | | | water, 1385 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 5 mg/kg
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(1), Pg. 73, 1982.
intravenous-mouse LD50 7990 ug/kg
Journal of Pharmacy and Pharmacology. Vol. 48, Pg. 1128, 1996.
oral-mouse LD50 16 mg/kg
Indian Journal of Experimental Biology. Vol. 18, Pg. 876, 1980.
oral-rat LD50 65 mg/kg
Indian Journal of Medical Research. Vol. 65, Pg. 829, 1977.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for plumbagin usage levels up to: | | | not for fragrance use.
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| Recommendation for plumbagin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5- | hydroxy-2-methyl-1,4-naphthalenedione | | 5- | hydroxy-2-methyl-1,4-naphthoquinone | | 5- | hydroxy-2-methylnaphthalene-1,4-dione | | 2- | methyl-5-hydroxy-1,4-naphthoquinone | | 2- | methyljuglone | | 1,4- | naphthalenedione, 5-hydroxy-2-methyl- | | 1,4- | naphthalenedione, 5-hydroxy-2-methyl- (9CI) | | 1,4- | naphthoquinone, 5-hydroxy-2-methyl- | | | plumbaein | | | plumbagine | | | plumbagone |
Articles:
| PubMed:Anti-tumor effects of novel 5-O-acyl plumbagins based on the inhibition of mammalian DNA replicative polymerase activity. |
| PubMed:Plumbagin inhibits LPS-induced inflammation through the inactivation of the nuclear factor-kappa B and mitogen activated protein kinase signaling pathways in RAW 264.7 cells. |
| PubMed:Antimicrobial activity of the carnivorous plant Dionaea muscipula against food-related pathogenic and putrefactive bacteria. |
| PubMed:Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones. |
| PubMed:Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. |
| PubMed:Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilage fungi. |
| PubMed:Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. |
| PubMed:Synthesis and insect antifeedant activity of plumbagin derivatives with the amino acid moiety. |
| PubMed:Impact of lactic acid bacteria on oxidative DNA damage in human derived colon cells. |
| PubMed:Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. |
| PubMed:CorA affects tolerance of Escherichia coli and Salmonella enterica serovar Typhimurium to the lactoperoxidase enzyme system but not to other forms of oxidative stress. |
| PubMed:High-performance liquid chromatography for quantification of plumbagin, an anti-Helicobacter pylori compound of Plumbago zeylanica L. |
| PubMed:Investigation into the resistance of lactoperoxidase tolerant Escherichia coli mutants to different forms of oxidative stress. |
| PubMed:Induction of oxidative stress by high hydrostatic pressure in Escherichia coli. |
| PubMed:Unique stress response to the lactoperoxidase-thiocyanate enzyme system in Escherichia coli. |
| PubMed:Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. |
| PubMed:Source of tryptone in growth medium affects oxidative stress resistance in Escherichia coli. |
| PubMed:Nepenthes insignis uses a C2-portion of the carbon skeleton of L-alanine acquired via its carnivorous organs, to build up the allelochemical plumbagin. |
| PubMed:Regulation of aflatoxin production by naphthoquinones of walnut (Juglans regia). |
| PubMed:Pro- and antioxidative properties of cortical tissue preparations from human brain exhibiting NMDA-receptor characteristics. |
| PubMed:Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. |
| PubMed:Differential toxicity of juglone (5-hydroxy-1,4-naphthoquinone) and related naphthoquinones to saturniid moths. |
| PubMed:[Evaluation of the sensitizing properties of plumbagin intended for use in the food industry]. |
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3D/inchi