| PubMed:Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies. |
| PubMed:Determination of the depth profile distribution of guest species in microporous materials using the voltammetry of immobilized particles methodology: application to lapachol attachment to palygorskite and kaolinite. |
| PubMed:Vasorelaxation induced by a new naphthoquinone-oxime is mediated by NO-sGC-cGMP pathway. |
| PubMed:Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity. |
| PubMed:The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression. |
| PubMed:Isolation and identification of α-glucosidase and protein glycation inhibitors from Stereospermum colais. |
| PubMed:Antiparasitic activities of novel ruthenium/lapachol complexes. |
| PubMed:Chemical markers of occupational exposure to teak wood dust. |
| PubMed:Cytotoxicity of lapachol metabolites produced by probiotics. |
| PubMed:Selective binding of naphthoquinone derivatives to serum albumin proteins and their effects on cytotoxicity. |
| PubMed:1,2,3-triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones. |
| PubMed:Electrochemical analysis in a liposome suspension using lapachol as a hydrophobic electro active species. |
| PubMed:Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives. |
| PubMed:Isolation of major components from the roots of Godmania aesculifolia and determination of their antifungal activities. |
| PubMed:Structural elucidation of the metabolites of lapachol in rats by liquid chromatography-tandem mass spectrometry. |
| PubMed:Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase. |
| PubMed:Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: electrochemical studies on the effects of the quinoidal moiety. |
| PubMed:β-Lapachone activity in synergy with conventional antimicrobials against methicillin resistant Staphylococcus aureus strains. |
| PubMed:Diterpenylquinone hybrids: synthesis and assessment of gastroprotective mechanisms of action in human cells. |
| PubMed:Anti-diabetic activity of active fractions of Stereospermum tetragonum DC and isolation of active principles. |
| PubMed:Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol. |
| PubMed:The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives. |
| PubMed:A conserved lysine residue controls iron-sulfur cluster redox chemistry in Escherichia coli fumarate reductase. |
| PubMed:Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. |
| PubMed:Electronic structure and gas-phase chemistry of protonated α- and β-quinonoid compounds: a mass spectrometry and computational study. |
| PubMed:Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells. |
| PubMed:Gas-phase reactivity of 2-hydroxy-1,4-naphthoquinones: a computational and mass spectrometry study of lapachol congeners. |
| PubMed:Addition of thiols to o-quinone methide: new 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7). |
| PubMed:A mechanistic study on the Hooker oxidation: synthesis of novel indane carboxylic acid derivatives from lapachol. |
| PubMed:From body art to anticancer activities: perspectives on medicinal properties of henna. |
| PubMed:Potential gastroprotective effect of novel cyperenoic acid/quinone derivatives in human cell cultures. |
| PubMed:Quinones derived from plant secondary metabolites as anti-cancer agents. |
| PubMed:Biomimetic in vitro oxidation of lapachol: a model to predict and analyse the in vivo phase I metabolism of bioactive compounds. |
| PubMed:A proteomic insight into the effects of the immunomodulatory hydroxynaphthoquinone lapachol on activated macrophages. |
| PubMed:Determination of lapachol in the presence of other naphthoquinones using 3MPA-CdTe quantum dots fluorescent probe. |
| PubMed:β-Lapachone analogs with enhanced antiproliferative activity. |
| PubMed:Lapacho tea (Tabebuia impetiginosa) extract inhibits pancreatic lipase and delays postprandial triglyceride increase in rats. |
| PubMed:Lapachol as an epithelial tumor inhibitor agent in Drosophila melanogaster heterozygote for tumor suppressor gene wts. |
| PubMed:A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro. |
| PubMed:Antimony(V) and bismuth(V) complexes of lapachol: synthesis, crystal structure and cytotoxic activity. |
| PubMed:Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives. |
| PubMed:Coordination of lapachol to bismuth(III) improves its anti-inflammatory and anti-angiogenic activities. |
| PubMed:Genotoxicity of lapachol evaluated by wing spot test of Drosophila melanogaster. |
| PubMed:Lapachol suppresses cell proliferation and secretion of interleukin-6 and plasminogen activator inhibitor-1 of fibroblasts derived from hypertrophic scars. |
| PubMed:β-lapachone accelerates the recovery of burn-wound skin. |
| PubMed:Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1. |
| PubMed:Natural products as starting points for future anti-malarial therapies: going back to our roots? |
| PubMed:Synthetic lapachol derivatives relax guinea-pig ileum by blockade of the voltage-gated calcium channels. |
| PubMed:Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease. |
| PubMed:The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages. |
| PubMed:Combination of chiroptical, absorption and fluorescence spectroscopic methods reveals multiple, hydrophobicity-driven human serum albumin binding of the antimalarial atovaquone and related hydroxynaphthoquinone compounds. |
| PubMed:Fragmentation studies and electrospray ionization mass spectrometry of lapachol: protonated, deprotonated and cationized species. |
| PubMed:LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells. |
| PubMed:Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol. |
| PubMed:1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. |
| PubMed:Lapachol induces clastogenic effects in rats. |
| PubMed:Acanthamoeba castellanii Neff: In vitro activity against the trophozoite stage of a natural sesquiterpene and a synthetic cobalt(II)-lapachol complex. |
| PubMed:1,2-Dihydr-oxy-2-(3-methyl-but-2-en-yl)-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid monohydrate. |
| PubMed:Effect of hydroxy substituent on the prooxidant action of naphthoquinone compounds. |
| PubMed:The trypanocidal activity of naphthoquinones: a review. |
| PubMed:LC-APCI mass spectrometric method development and validation for the determination of atovaquone in human plasma. |
| PubMed:Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster. |
| PubMed:Crystal and molecular structure of manganese(II) lapacholate, a novel polymeric species undergoing temperature-reversible metal to ligand electron transfer. |
| PubMed:Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells. |
| PubMed:Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats. |
| PubMed:Dolichandroside A, a new alpha-glucosidase inhibitor and DPPH free-radical scavenger from Dolichandrone falcata seem. |
| PubMed:Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? |
| PubMed:Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol. |
| PubMed:Antitumor activity of two derivatives from 2-acylamine-1, 4-naphthoquinone in mice bearing S180 tumor. |
| PubMed:Antitumoral activity of new polyamine-naphthoquinone conjugates. |
| PubMed:Development of lapachol topical formulation: anti-inflammatory study of a selected formulation. |
| PubMed:Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones. |
| PubMed:Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol. |
| PubMed:Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms. |
| PubMed:Antimicrobial activity of the methanolic extract and of the chemical constituents isolated from Newbouldia laevis. |
| PubMed:Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA. |
| PubMed:Quinones from plants of northeastern Brazil: structural diversity, chemical transformations, NMR data and biological activities. |
| PubMed:Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment. |
| PubMed:Applications of counter-current chromatography in organic synthesis purification of heterocyclic derivatives of lapachol. |
| PubMed:Antifungal chemical compounds identified using a C. elegans pathogenicity assay. |
| PubMed:Novel rearranged abietane diterpenoids from the roots of Salvia sahendica. |
| PubMed:Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone. |
| PubMed:Constituents of the root wood of Austroplenckia populnea var. ovata. |
| PubMed:Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis. |
| PubMed:Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi. |
| PubMed:Microwave-assisted rapid cyclization of lapachol, a main constituent of Heterophragma adenophyllum. |
| PubMed:Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevis. |
| PubMed:Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori. |
| PubMed:Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties. |
| PubMed:Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae. |
| PubMed:New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity. |
| PubMed:Acrosome reaction in bovine spermatozoa: role of reactive oxygen species and lactate dehydrogenase C4. |
| PubMed:Newbouldiaquinone and newbouldiamide: a new naphthoquinone-anthraquinone coupled pigment and a new ceramide from Newbouldia laevis. |
| PubMed:Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. |
| PubMed:Cytotoxic pyranonaphthoquinones from Melloa quadrival vis (Bignoniaceae). |
| PubMed:Antileishmanial activity of lapachol analogues. |
| PubMed:Demonstration of the lapachol as a potential drug for reducing cancer metastasis. |
| PubMed:Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives. |
| PubMed:Photoreactions of 1,4-Naphthoquinones: effects of substituents and water on the intermediates and reactivity. |
| PubMed:NO reductase from Bacillus azotoformans is a bifunctional enzyme accepting electrons from menaquinol and a specific endogenous membrane-bound cytochrome c551. |
| PubMed:Isolation of colour components from native dye-bearing plants in northeastern India. |
| PubMed:Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. |
| PubMed:Glutamate 87 is important for menaquinol binding in DmsC of the DMSO reductase (DmsABC) from Escherichia coli. |
| PubMed:Monoarylhydrazones of alpha-lapachone: synthesis, chemical properties and antineoplastic activity. |
| PubMed:Naphthoquinone derivatives and lignans from the Paraguayan crude drug "tayï pytá" (Tabebuia heptaphylla, Bignoniaceae). |
| PubMed:Electrochemical study of oxygen interaction with lapachol and its radical anions. |
| PubMed:Inhibitory effects of lapachol derivatives on epstein-barr virus activation. |
| PubMed:Fetal growth in rats treated with lapachol. |
| PubMed:The anatomy and chemistry of the colour bands of grasstree stems (Xanthorrhoea preissii) used for plant age and fire history determination. |
| PubMed:New enamine derivatives of lapachol and biological activity. |
| PubMed:Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica. |
| PubMed:Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol. |
| PubMed:Radermachera xylocarpa: the highly efficient source of lapachol and synthesis of its derivatives. |
| PubMed:Toxicology of Lapachol in rats: embryolethality. |
| PubMed:Molluscicidal and trypanocidal activities of lapachol derivatives. |
| PubMed:Occupational allergic contact dermatitis caused by wood dusts. |
| PubMed:Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy. |
| PubMed:In vitro and in vivo Leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). |
| PubMed:Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives. |
| PubMed:Chemical characterization and biological activity of Macfadyena unguis-cati (Bignoniaceae). |
| PubMed:Chemical constituents of Avicennia alba. Isolation and structural elucidation of new naphthoquinones and their analogues. |
| PubMed:Interceptive effect of Lapachol in rats. |
| PubMed:Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. |
| PubMed:Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth. |
| PubMed:Antimicrobial and antiinflammatory activities of extracts and constituents of Oroxylum indicum (L.) Vent. |
| PubMed:Inhibition of nitric oxide formation by neuronal nitric oxide synthase by quinones: nitric oxide synthase as a quinone reductase. |
| PubMed:Hydroxylated naphthoquinones as substrates for Escherichia coli anaerobic reductases. |
| PubMed:Bioactivation of lapachol responsible for DNA scission by NADPH-cytochrome P450 reductase. |
| PubMed:The search for novel anticancer agents: a differentiation-based assay and analysis of a folklore product. |
| PubMed:Bioactive furonaphtoquinones from Tabebuia barbata (Bignoniaceae). |
| PubMed:Antibacterial and antifungal compounds from Kigelia pinnata. |
| PubMed:[Tumors caused by methylcholanthrene and lapachol. Follow-up of development with cytology]. |
| PubMed:Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines. |
| PubMed:Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. |
| PubMed:Radiosensitization by nickel lapachol. |
| PubMed:Phytochemical and analgesic investigation of Tabebuia chrysotricha. |
| PubMed:Screening in vitro of natural products against blood forms of Trypanosoma cruzi. |
| PubMed:Antiinflammatory action of lapachol. |
| PubMed:Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition. |
| PubMed:Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. |
| PubMed:Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I. |
| PubMed:In vitro activity of natural and synthetic naphthoquinones against erythrocytic stages of Plasmodium falciparum. |
| PubMed:Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion. |
| PubMed:Antiviral activity of naphthoquinones. I. Lapachol derivatives against enteroviruses. |
| PubMed:Antiviral activity of naphthoquinones. I. Lapachol derivatives against enteroviruses. |
| PubMed:Lapachol inhibition of DT-diaphorase (NAD(P)H:quinone dehydrogenase). |
| PubMed:Isolation of lapachol from Diphysa robinoides. |
| PubMed:Modulation of cytotoxicity of menadione sodium bisulfite versus leukemia L1210 by the acid-soluble thiol pool. |
| PubMed:Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver. |
| PubMed:Potentiation of antimetabolite action by uridylate trapping. |
| PubMed:Uridylate-trapping sugar analogs in combination with inhibitors of uridylate synthesis de novo and 5-fluorouridine. |
| PubMed:Lapachol inhibition of vitamin K epoxide reductase and vitamin K quinone reductase. |
| PubMed:Oxidative ring fission of the naphthoquinones lapachol and dichloroallyl lawsone by Penicillium notatum. |
| PubMed:Naturally occurring quinones as potential bioreductive alkylating agents. |
| PubMed:Restoration of active transport of solutes and oxidative phosphorylation by naphthoquinones in irradiated membrane vesicles from Mycobacterium phlei. |
| PubMed:Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata. |
| PubMed:Dichloroallyl lawsone. |
| PubMed:In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi. |
| PubMed:Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum. |
| PubMed:The sensitizing capacity of naturally occurring quinones. Experimental studies in guinea pigs. I. Naphthoquinones and related compounds. |
| PubMed:Schistosomiasis mansoni: blockage of cercarial skin penetration by chemical agents: i. naphthoquinones and derivatives. |
| PubMed:Pharmacology of antitumor agents from higher plants. |
| PubMed:Lapachol: a new acid-base indicator. |
| PubMed:A lapachol derivative active against mouse lymphocytic leukemia P-388. |
| PubMed:Early clinical studies with lapachol (NSC-11905). |
| PubMed:Quinone natural products: streptonigrin (NSC-45383) and lapachol (NSC-11905) structure-activity relationships. |
| PubMed:Schistosoma mansoni chemoprophylaxis with dietary lapachol. |
| PubMed:[Antimicrobial substances from higher plants. XXXV. Antimicrobial or antineoplastic activity of lawsona (2-hydroxy-1,4-naphthoquinone) in comparison with lapachol (2-hydroxy-3-(-3-methyl-2-butanyl)-1,4-naphthoquinone]. |
| PubMed:Function of ubiquinone in electron transport from reduced nicotinamide adenine dinucleotide to nitrate and oxygen in Aerobacter aerogenes. |
| PubMed:Oral toxicology studies with lapachol. |
| PubMed:Fluorometric method for the determination of lapachol in serum. |
| PubMed:The induction of ATP energized mitochondrial volume changes by the combination of the two antitumor age agents showdomycin and lapachol. |
| PubMed:Lapachol. |
| PubMed:Syntheses in the lapachol series. |
| PubMed:Hooker's researches on lapachol in relation to new developments in the field of chemotherapy. |
3D/inchi