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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | 0.978 (est) |
| Soluble in: |
| | water, 401.9 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for isatoic anhydride usage levels up to: | | | not for fragrance use.
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| Recommendation for isatoic anhydride flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | anthranilic acid N-carboxylic acid anhydride | | | anthranilic acid, N-carboxy-, cyclic anhydride | | 1H- | benzo[d][1,3]oxazine-2,4-dione | | | benzoic acid, 2-(carboxyamino)-, cyclic anhydride | | 1H-3,1- | benzoxazine-2,4-dione | | 1H-3,1- | benzoxazine-2,4-quinone | | 2H-3,1- | benzoxazine-2,4(1H)-dione | | 4H-3,1- | benzoxazine-2,4(1H)-dione | | | isatoic acid anhydride | | | isatoicanhydride |
Articles:
| PubMed:Efficient [Formula: see text]-catalyzed synthesis of novel and diverse 2,3-dihydroquinazolin-4(1[Formula: see text])-ones. |
| PubMed:Efficient synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones catalyzed by dodecylbenzenesulfonic acid in aqueous media under ultrasound irradiation. |
| PubMed:Inorganic-organic hybrid silica based tin complex as a novel, highly efficient and recyclable heterogeneous catalyst for the one-pot preparation of spirooxindoles in water. |
| PubMed:One-pot synthesis of 2-amino-4(3H)-quinazolinones via ring-opening of isatoic anhydride and palladium-catalyzed oxidative isocyanide-insertion. |
| PubMed:Biotin-conjugated N-methylisatoic anhydride: a chemical tool for nucleic acid separation by selective 2'-hydroxyl acylation of RNA. |
| PubMed:Synthesis and biological evaluation of 2-aminobenzamide derivatives as antimicrobial agents: opening/closing pharmacophore site. |
| PubMed:N,N'-(Propane-1,3-di-yl)bis-(2-amino-benzamide). |
| PubMed:The folding of the hepatitis C virus internal ribosome entry site depends on the 3'-end of the viral genome. |
| PubMed:Palladium-catalyzed regioselective carbonylation of C-H bonds of N-alkyl anilines for synthesis of isatoic anhydrides. |
| PubMed:A highly efficient green synthesis of N-alkyl 2-[(2-oxo-2-aryl ethyl) amino] benzamide derivatives from reaction of isatoic anhydride, primary amines and 2-bromoacethophenone. |
| PubMed:Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives. |
| PubMed:Hydrolase-like properties of a cofactor-independent dioxygenase. |
| PubMed:A new cascade reaction: concurrent construction of six and five membered rings leading to novel fused quinazolinones. |
| PubMed:Palladium-catalyzed decarboxylative coupling of isatoic anhydrides with arylboronic acids. |
| PubMed:1,3-Dipolar cycloaddition-decarboxylation reactions of an azomethine ylide with isatoic anhydrides: formation of novel benzodiazepinones. |
| PubMed:Synthesis of 2,3-dihydroquinazolin-4(1H)-ones by three-component coupling of isatoic anhydride, amines, and aldehydes catalyzed by magnetic Fe(3)O(4) nanoparticles in water. |
| PubMed:Glycosylation, sugar hydrazones, and antimicrobial evaluation of some 6-substituted-1,2,4-triazines. |
| PubMed:Cytotoxicity and reversal of multidrug resistance by tryptanthrin-derived indoloquinazolines. |
| PubMed:Reactions of ortho-lithiophenyl (-hetaryl) isocyanides with carbonyl compounds: rearrangements of 2-metalated 4H-3,1-benzoxazines. |
| PubMed:Time-resolved RNA SHAPE chemistry. |
| PubMed:Novel and efficient one-pot tandem synthesis of 2-styryl-substituted 4(3H)-quinazolinones. |
| PubMed:Synthesis, NMR and crystallographic studies of 2-substituted dihydroquinazolinones derived from (S)-phenylethylamine. |
| PubMed:96-well plate-to-plate gravity fluorous solid-phase extraction (F-SPE) for solution-phase library purification. |
| PubMed:Automated liquid-liquid extraction workstation for library synthesis and its use in the parallel and chromatography-free synthesis of 2-alkyl-3-alkyl-4-(3H)-quinazolinones. |
| PubMed:Hydrogen-bonding in 2-aminobenzoyl-alpha-chymotrypsin formed by acylation of the enzyme with isatoic anhydride: IR and mass spectroscopic studies. |
| PubMed:Practical synthesis of potential endothelin receptor antagonists of 1,4-benzodiazepine-2,5-dione derivatives bearing substituents at the C3-, N1- and N4-positions. |
| PubMed:Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison. |
| PubMed:Plate-to-plate fluorous solid-phase extraction for solution-phase parallel synthesis. |
| PubMed:A direct, continuous, sensitive assay for protein disulphide-isomerase based on fluorescence self-quenching. |
| PubMed:The energetics of isomeric benzoxazine diones: isatoic anhydride revisited. |
| PubMed:Are isatin and isatoic anhydride antiaromatic and aromatic respectively? A combined experimental and theoretical investigation. |
| PubMed:Synthesis and pharmacological activity of 1,4-benzodiazepine derivatives. |
| PubMed:An efficient, convenient synthesis of novel medium-sized 13H-dibenzo[d,h][1,3,7]oxadiazecine-8,14-dione macrolides as anticipated antineoplastic agents. |
| PubMed:Stereoselective Synthesis of Tilivalline(1). |
| PubMed:Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. |
| PubMed:Aminoacyl-tRNA analogues; synthesis, purification and properties of 3'-anthraniloyl oligoribonucleotides. |
| PubMed:Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents. |
| PubMed:Preliminary synthetic studies of methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist: rapid syntheses of AE-bicyclic analogues. |
| PubMed:Further search for small molecular inactivants capable of eliciting respiratory mucosal immunogenicity by modifying Sendai virus core RNA. |
| PubMed:Rates of thrombin acylation and deacylation upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylating agents. |
| PubMed:[Polycyclic azines with heteroatoms in the 1- and 3-position. 40. Synthesis of heterocyclic immunomodulators. 3. Synthesis of n-1 substituted 3-(2-mercaptoethyl)quinazoline-2,4-(1H,3H)-diones from bis(2-(2-aminobenzoylamino)ethyl)disulfane and testing of immunostimulant activity]. |
| PubMed:The kinetics of non-stoichiometric bursts of beta-lactam hydrolysis catalysed by class C beta-lactamases. |
| PubMed:Fluorescence properties of o-aminobenzoyl-labeled proteins. |
| PubMed:tRNA fluorescent labeling at 3' end inducing an aminoacyl-tRNA-like behavior. |
| PubMed:Inactivation of arginine esterase E-I of Bitis gabonica venom by irreversible inhibitors including a water-soluble carbodiimide, a chloromethyl ketone and isatoic anhydride. |
| PubMed:Biosynthesis and modulation of endothelin from bovine pulmonary arterial endothelial cells. |
| PubMed:Antihypertensive activity of 2[(2-hydroxyphenyl)amino]-4(3H)-quinazolinone. |
| PubMed:Substituted isatoic anhydrides: selective inactivators of trypsin-like serine proteases. |
| PubMed:Assessment of antiprotease activity of some carbamate derivatives. |
| PubMed:New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as substrates for various enzymes. |
| PubMed:Suicide enzyme inactivators. |
| PubMed:New fluorescent analogs of cAMP and cGMP available as substrates for cyclic nucleotide phosphodiesterase. |
| PubMed:Nicafenine, a new analgesic. I. Synthesis and physicochemical properties. |
| PubMed:Aromatic amines condensed with aminothiazoles, directly and with isatoic anhydride, for schistosomiasis treatment I. |
| PubMed:Antifertility effects of isatoic anhydride and derivatives. |
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3D/inchi