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hexamethylene tetramine
1,5,7-tetraazatricyclo[3.3.1.13,7]decane

Supplier Sponsors

CAS Number: 100-97-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-905-8
FDA UNII:J50OIX95QV
Nikkaji Web:J39.765B
Beilstein Number:0002018
MDL:MFCD00006895
XlogP3-AA:0.30 (est)
Molecular Weight:140.18964000
Formula:C6 H12 N4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Hexamethylene tetramine View - review
JECFA Food Additive: Hexamethylenetetramine
GSFA Codex: Hexamethylene tetramine (239)
DG SANTE Food Additives:hexamethylene tetramine
DG SANTE Food Contact Materials:hexamethylene tetramine
FDA Mainterm (IAUFC):100-97-0 ; HEXAMETHYLENETETRAMINE
 
Physical Properties:
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 280.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.004000 mmHg @ 25.00 °C. (est)
Flash Point: 482.00 °F. TCC ( 250.00 °C. )
logP (o/w): -4.150 (est)
Soluble in:
 water, 449000 mg/L @ 12C (exp)
Stability:
 ph from 5 - 12
 up to 21.3% naoh
 up to 25.4% nacl
 up to 7.1% nahco3
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
Charkit Chemical
HEXAMINE GRANULAR
ECSA Chemicals
HEXAMETHYLENETETRAMINE RPE-FOR ANALYSIS, G 2
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
HEXAMETHYLENETETRAMINE RPE-FOR ANALYSIS, KG
EMD Millipore
For experimental / research use only.
Hexamethylenetetramine
OQEMA
Hexamine
Santa Cruz Biotechnology
For experimental / research use only.
Hexamethylenetetramine ≥99%
Sigma-Aldrich
For experimental / research use only.
Hexamethylenetetramine ACS reagent, ≥99.0%
TCI AMERICA
For experimental / research use only.
Hexamethylenetetramine >99.0%(GC)(T)
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 9200 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 221, Pg. 166, 1954.

oral-mouse LD50 569 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 115, 1970.

intravenous-mouse LD50 17700 ul/kg
Antibiotiki. Vol. 20, Pg. 891, 1975.

parenteral-cat LDLo 200 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

parenteral-mammal (species unspecified) LDLo 300 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

parenteral-mouse LDLo 450 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

parenteral-rat LDLo 200 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

Dermal Toxicity:
subcutaneous-mouse LD50 215 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: TREMOR
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 225, Pg. 428, 1955.

subcutaneous-cat LDLo 200 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 84, 1955.

subcutaneous-guinea pig LDLo 300 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 84, 1955.

subcutaneous-rat LDLo 200 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 84, 1955.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antimicrobial agents
Recommendation for hexamethylene tetramine usage levels up to:
 not for fragrance use.
 
Recommendation for hexamethylene tetramine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of hexamethylene tetramine (E 239) as a food additive
View page or View pdf

Scientific Opinion on the safety and efficacy of hexamethylene tetramine as a silage additive for pigs, poultry, bovines, sheep, goats, rabbits and horses
View page or View pdf

Safety of hexamethylene tetramine for pigs, poultry, bovines, sheep, goats, rabbits and horses
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):100-97-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :4101
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0000100970
EPA/NOAA CAMEO:hazardous materials
RTECS:100-97-0
 
References:
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:100-97-0
Pubchem (cid):4101
Pubchem (sid):134973022
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D00393
HMDB (The Human Metabolome Database):HMDB29598
FooDB:FDB000762
Export Tariff Code:2933.99.9701
FDA Listing of Food Additive Status:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 aminoformaldehyde
 ammonioformaldehyde
 formamine
 hexamethylenamine
 hexamethylene tetramine
 hexamethyleneamine
 hexamethylenetetraamine
 hexamethylenetetramine
 hexamethylenetetramine [UN1328] [Flammable solid]
 hexamethylenetetraminum
 hexamethylentetramine
 hexamine
 methenamine
1,3,5,7-tetraaza-tricyclo3.3.1.13,7decane
1,3,5,7-tetraazaadamantane
1,3,5,7-tetraazatricyclo (3.3.1.1(3,7))decane
1,3,5,7-tetraazatricyclo(3.3.1.1(3,7))decane
1,3,5,7-tetraazatricyclo(3.3.1.1(sup 3,7))decane
1,3,5,7-tetraazatricyclo(3.3.1.1(sup 37))decane
1,3,5,7-tetraazatricyclo(3.3.1.13,7)decane
1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane
1,3,5,7-tetraazatricyclo[3.3.1.13,7 ]decane
1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane
1,5,7-tetraazatricyclo[3.3.1.13,7]decane
1,3,5,7-tetraazatricyclo[3.3.1.1<3,7>]decane
1,3,5,7-tetraazatricyclo[3.3.1.1∼3,7∼]decane
 
 
Notes:
an anti-infective agent most commonly used in the treatment of urinary tract infections. its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic ph. (from martindale, the extra pharmacopoeia, 30th ed, p173) Antimicrobial food preservative, but limited and declining use. Acts by releasing formaldehyde in acidic conditions. Prevents "late blowing" of hard cheese by inhibiting growth of unwanted bacteria. Presently (2002) its European use is limited to one type of Italian cheese, Provolone
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