glycyl glycine
2-(2-aminoacetylamino)acetic acid

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  CODE124859 CODE124859
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  556-50-3 Gly-Gly ≥99% (Titration)

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Name: 2-[(2-aminoacetyl)amino]acetic acid CAS Number: 556-50-3 3D/inchi Other(deleted CASRN): 61499-00-1 ECHA EINECS - REACH Pre-Reg: 209-127-8 FDA UNII: 10525P22U0 Nikkaji Web: J2.659J Beilstein Number: 1765223 MDL: MFCD00008130 XlogP3: -2.90 (est) Molecular Weight: 132.11936000 Formula: C4 H8 N2 O3 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:cosmetic ingredient for skin and hair conditioning   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 215.00 °C. @ 760.00 mm Hg Boiling Point: 453.24 °C. @ 760.00 mm Hg (est) Flash Point: 442.00 °F. TCC ( 227.90 °C. ) (est) logP (o/w): -2.291 (est) Soluble in:   water, 1.66E+05 mg/L @ 21C (exp)   water, 1e+006 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: hair conditioning skin conditioning   Suppliers: BOC Sciences For experimental / research use only. Gly-Gly ≥99% (Titration) Glentham Life Sciences Gly-Gly Penta International GLYCYLGLYCINE Santa Cruz Biotechnology For experimental / research use only. Glycylglycine, Free Base ≥99% Sigma-Aldrich: Sigma For experimental / research use only. Gly-Gly ≥99% (titration) sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: cosmetic ingredient for skin and hair conditioning Recommendation for glycyl glycine usage levels up to:   not for fragrance use.   Recommendation for glycyl glycine flavor usage levels up to:   not for flavor use.   Safety References: European Food Safety Authority (EFSA) reference(s): Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):556-50-3 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :11163 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 2-[(2-aminoacetyl)amino]acetic acid Chemidplus:0000556503   References:   2-[(2-aminoacetyl)amino]acetic acid NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 556-50-3 Pubchem (cid): 11163 Pubchem (sid): 134976874   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View Golm Metabolome Database: Search KEGG (GenomeNet): C02037 HMDB (The Human Metabolome Database): HMDB11733 FooDB: FDB028413 Export Tariff Code: 2924.10.1050 ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: [( aminoacetyl)amino]acetic acid 2-[(2- aminoacetyl)amino]acetic acid 2-(2- aminoacetylamino)acetic acid   diglycine   diglycocoll   glycine, glycyl-   glycine, N-glycyl-   glycyl-glycine   glycylglycine N- glycylglycine   Articles:   None found yet. Try the PubMed Search.

Notes: the simplest of all peptides. it functions as a gamma-glutamyl acceptor. The simplest peptide, made of two glycine molecules; used in the synthesis of more complicated peptides. Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895) [HMDB]