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glycyl glycine
2-(2-aminoacetylamino)acetic acid

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Name:2-[(2-aminoacetyl)amino]acetic acid
CAS Number: 556-50-3Picture of molecule3D/inchi
Other(deleted CASRN):61499-00-1
ECHA EINECS - REACH Pre-Reg:209-127-8
FDA UNII:10525P22U0
Nikkaji Web:J2.659J
Beilstein Number:1765223
MDL:MFCD00008130
XlogP3:-2.90 (est)
Molecular Weight:132.11936000
Formula:C4 H8 N2 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic ingredient for skin and hair conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 215.00 °C. @ 760.00 mm Hg
Boiling Point: 453.24 °C. @ 760.00 mm Hg (est)
Flash Point: 442.00 °F. TCC ( 227.90 °C. ) (est)
logP (o/w): -2.291 (est)
Soluble in:
 water, 1.66E+05 mg/L @ 21C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Gly-Gly ≥99% (Titration)
Glentham Life Sciences
Gly-Gly
Penta International
GLYCYLGLYCINE
Santa Cruz Biotechnology
For experimental / research use only.
Glycylglycine, Free Base ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Gly-Gly ≥99% (titration)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin and hair conditioning
Recommendation for glycyl glycine usage levels up to:
 not for fragrance use.
 
Recommendation for glycyl glycine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):556-50-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11163
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-[(2-aminoacetyl)amino]acetic acid
Chemidplus:0000556503
 
References:
 2-[(2-aminoacetyl)amino]acetic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:556-50-3
Pubchem (cid):11163
Pubchem (sid):134976874
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C02037
HMDB (The Human Metabolome Database):HMDB11733
FooDB:FDB028413
Export Tariff Code:2924.10.1050
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
[(aminoacetyl)amino]acetic acid
2-[(2-aminoacetyl)amino]acetic acid
2-(2-aminoacetylamino)acetic acid
 diglycine
 diglycocoll
 glycine, glycyl-
 glycine, N-glycyl-
 glycyl-glycine
 glycylglycine
N-glycylglycine
 
 
Notes:
the simplest of all peptides. it functions as a gamma-glutamyl acceptor. The simplest peptide, made of two glycine molecules; used in the synthesis of more complicated peptides. Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895) [HMDB]
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