EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

formaldehyde
methaldehyde

Supplier Sponsors

Name:formaldehyde
CAS Number: 50-00-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-001-8
FDA UNII:1HG84L3525
Nikkaji Web:J2.294B
Beilstein Number:1209228
MDL:MFCD00003274
XlogP3-AA:1.20 (est)
Molecular Weight:30.02614000
Formula:C H2 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food-contact surface of paper and paperboard
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:formaldehyde
FDA Mainterm (SATF):50-00-0 ; FORMALDEHYDE
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.340 Defoaming agents.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.210 Acrylate ester copolymer coating.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.200 Defoaming agents used in coatings.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1200 Cellophane.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2410 Phenolic resins in molded articles.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3120 Animal glue.


FDA PART 573 -- FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS
Subpart B--Food Additive Listing
Sec. 573.460 Formaldehyde.
 
Physical Properties:
Food Chemicals Codex Listed: No
Specific Gravity:1.08300 @ 25.00 °C.
Boiling Point: -19.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure:3463.820068 mmHg @ 25.00 °C. (est)
Flash Point: 133.00 °F. TCC ( 56.11 °C. )
logP (o/w): 0.350
Soluble in:
 water, 400000 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
ECSA Chemicals
FORMALDEHYDE 24%
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
FORMALDEHYDE 36%
ECSA Chemicals
FORMALDEHYDE 37% M/V RPE-FOR ANALYSIS, L 5
ECSA Chemicals
FORMALDEHYDE 40% M/V RPE-FOR ANALYSIS, ML 10
ECSA Chemicals
FORMALDEHYDE 40%
Kraft Chemical
Formaldehyde
Krunal Group
Formaldehyde
Penta International
FORMALDEHYDE 37% SOLUTION
Sigma-Aldrich: Sigma
For experimental / research use only.
Formaldehyde solution for molecular biology, 36.5-38% in H2O
Wedor Corporation
FORMALDEHYDE
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 30 mg/kg
BLOOD: OTHER CHANGES
Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 275, 1952.

intravenous-dog LDLo 70 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

parenteral-frog LDLo 800 ug/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

oral-guinea pig LD50 260 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

unreported-man LDLo 477 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

oral-man TDLo 643 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Japanese Journal of Toxicology. Vol. 4, Pg. 261, 1991.

oral-man TDLo 646 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: GASTRITIS
Japanese Journal of Toxicology. Vol. 4, Pg. 261, 1991.

oral-mouse LD50 42 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. AD-A125-539

intraperitoneal-mouse LDLo 16 mg/kg
Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.

intravenous-rabbit LDLo 48 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.

intravenous-rat LD50 87 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 221, Pg. 166, 1954.

oral-rat LD50 100 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 447, 1988.

Dermal Toxicity:
subcutaneous-dog LDLo 350 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

subcutaneous-mouse LD50 300 mg/kg
LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.

skin-rabbit LD50 270 uL/kg
Union Carbide Data Sheet. Vol. 4/21/1967

subcutaneous-rabbit LDLo 240 mg/kg
JAMA, Journal of the American Medical Association. Vol. 62, Pg. 984, 1914.

subcutaneous-rat LD50 420 mg/kg
LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.

Inhalation Toxicity:
inhalation-cat LCLo 400 mg/m3/2H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 69, 1982.

inhalation-human TCLo 17 mg/m3/30M
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
JAMA, Journal of the American Medical Association. Vol. 165, Pg. 1908, 1957.

inhalation-man TCLo 300 ug/m3
BEHAVIORAL: AGGRESSION SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 12(7), Pg. 20, 1968.

inhalation-mouse LC50 454000 mg/m3/4H
Current Toxicology. Vol. 1, Pg. 47, 1993.

inhalation-rat LC50 203 mg/m3
BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 55, 1974.

 
Safety in Use Information:
Category:
food-contact surface of paper and paperboard
Recommendation for formaldehyde usage levels up to:
 not for fragrance use.
 
Recommendation for formaldehyde flavor usage levels up to:
 not for flavor use.
NOEL (No Observed Effect Level): 15 (mg/kg bw per day)
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Report of ESCO WG on non-plastic Food Contact Materials
View page or View pdf

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to use of formaldehyde as a preservative during the manufacture and preparation of food additives
View page or View pdf

Reasoned opinion on the modification of the existing MRLs for metaldehyde in certain legume vegetables and pulses
View page or View pdf

Scientific Opinion on the re-evaluation of hexamethylene tetramine (E 239) as a food additive
View page or View pdf

Scientific Opinion on the safety and efficacy of formaldehyde as a feed hygiene substance in feed for pigs and poultry
View page or View pdf

EFSA scientific advice to EC on accumulating formaldehyde in GM soybeans
View page or View pdf

EPI System: View
EPA-Iris:IRIS
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):50-00-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :712
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
formaldehyde
Chemidplus:0000050000
EPA/NOAA CAMEO:hazardous materials
RTECS:50-00-0
 
References:
 formaldehyde
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:50-00-0
Pubchem (cid):712
Pubchem (sid):134970847
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00067
HMDB (The Human Metabolome Database):HMDB01426
FooDB:FDB009445
YMDB (Yeast Metabolome Database):YMDB00321
Export Tariff Code:2912.11.0000
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•pure formaldehyde is not avail commercially because of its tendency to polymerize. it is sold as aqueous solutions containing from 37% to 50% formaldehyde by wt & varying amounts of methanol. •marketed under the trade name formcel, soln in methanol, n-butanol, and isobutanol. ... •aq formaldehyde, known as formalin, is usually 37% by weight of formaldehyde, though more concn soln are available. formalin is the general-purpose formaldehyde of commerce supplied unstabilized or methanol-stabilized. formaldehyde may also exist in the form of the cyclic trimer trioxane. this is a fairly stable cmpd that does not easily release formaldehyde. ... •grade: aqueous solutions: 37%, 44%, 50% inhibited (with varying percentages of methanol) or stabilized or unstabilized (methanol-free), also available in solution in n-butanol, ethanol, or urea; usp (37% aqueous solution containing methanol). •soluble concentrate; hot fogging concentrate •formaldehyde is available in the united states as as paraformaldehyde. paraformaldehyde is available as a powdered or flaked product that contains the equivalent of 90-93% formaldehyde, a maximum of 9% water, and a maximum of 0.03% acidity as formic acid. it is readily soluble in hot water with the evolution of formaldehyde vapors ... •formalin consists of an aqueous solution of formaldehyde, usually containing about 37% formaldehyde and 12-15% methanol. formalin
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 beet root
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 celery plant
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 celery shoot
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 currant black currant fruit
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 not found in nature
 oat seed
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 pear plant
Search Trop Picture
 
Synonyms:
 formalin
 formic aldehyde
 formol
 methaldehyde
 methanal
 methyl aldehyde
 paraform
 

Articles:

Info:Formaldehyde
PubMed:Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies.
PubMed:The influence of douchi starter cultures on the composition of extractive components, microbiological activity, and sensory properties of fermented fish pastes.
PubMed:Thermal generation of 3-amino-4,5-dimethylfuran-2(5H)-one, the postulated precursor of sotolone, from amino acid model systems containing glyoxylic and pyruvic acids.
PubMed:A liquid chromatographic method optimization for the assessment of low and high molar mass carbonyl compounds in wines.
PubMed:Analysis of selected carbonyl oxidation products in wine by liquid chromatography with diode array detection.
PubMed:Toxicologic evaluation of licorice extract as a cigarette ingredient.
PubMed:Carcass, sensory, and adipose tissue traits of Brangus steers fed casein-formaldehyde-protected starch and/or canola lipid.
PubMed:Effects of treatment of whole fat soybeans or soy flour with formaldehyde to protect the polyunsaturated fatty acids from biohydrogenation in the rumen.
 
Notes:
a highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. in solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (from reynolds, martindale the extra pharmacopoeia, 30th ed, p717) A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons.
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