EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

diphenhydramine HCL
2-(benzhydryloxy)-N,N-dimethylethanamine hydrochloride

Supplier Sponsors

CAS Number: 147-24-0Picture of molecule3D/inchi
Other(deleted CASRN):8052-21-9
ECHA EINECS - REACH Pre-Reg:205-687-2
FDA UNII:TC2D6JAD40
MDL:MFCD00012479
Formula:C17 H21 N O.Cl H
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 343.70 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000069 mmHg @ 25.00 °C. (est)
Flash Point: 215.00 °F. TCC ( 101.50 °C. ) (est)
logP (o/w): 3.662 (est)
Soluble in:
 water, 602.4 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Diphenhydramine Hydrochloride 98%
American International Chemical, LLC.
Diphenhydramine HCl
BOC Sciences
For experimental / research use only.
Diphenhydramine HCl >98%
Odor: characteristic
Use: Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations.
Glentham Life Sciences
Diphenhydramine hydrochloride
Penta International
DIPHENHYDRAMINE HCL USP
Santa Cruz Biotechnology
For experimental / research use only.
Diphenhydramine Hydrochloride ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Diphenhydramine hydrochloride ≥98% (TLC)
TCI AMERICA
For experimental / research use only.
Diphenhydramine Hydrochloride >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-child TDLo 12500 ug/kg
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pediatrics. Vol. 90, Pg. 1017, 1977.

intravenous-dog LD50 24 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 227, 1947.

intraperitoneal-guinea pig LD50 75 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 83, Pg. 120, 1945.

oral-guinea pig LD50 280 mg/kg
Journal of Allergy. Vol. 27, Pg. 57, 1956.

intravenous-hamster LD50 18 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949.

intraperitoneal-mammal (species unspecified) LD50 80 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 328, 1953.

oral-man TDLo 10714 ug/kg
AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
American Journal of Emergency Medicine. Vol. 4, Pg. 369, 1986.

intraperitoneal-mouse LD50 56 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 112, Pg. 318, 1954.

intravenous-mouse LD50 20 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.

oral-mouse LD50 164 mg/kg
Drugs in Japan Vol. -, Pg. 550, 1995.

intravenous-rabbit LD50 10 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 150, 1945.

intraperitoneal-rat LD50 82 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 250, 1951.

intravenous-rat LD50 35 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.

oral-rat LD50 500 mg/kg
Drugs in Japan Vol. 6, Pg. 334, 1982.

Dermal Toxicity:
skin-child TDLo 60 mg/kg/6H-I
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Clinical Pediatrics Vol. 25, Pg. 163, 1986.

subcutaneous-guinea pig LD50 40 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.

subcutaneous-mouse LD50 99200 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 33, 1958.

subcutaneous-rat LD50 201 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 261, 1961.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for diphenhydramine HCL usage levels up to:
 not for fragrance use.
 
Recommendation for diphenhydramine HCL flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8980
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
Chemidplus:0000147240
EPA/NOAA CAMEO:hazardous materials
RTECS:KR7000000 for cas# 147-24-0
 
References:
 2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):8980
Pubchem (sid):134975097
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07784
HMDB (The Human Metabolome Database):HMDB01927
Export Tariff Code:2922.19.7000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•hydrochloride...bax, benadryl, benocten, benzehist, dabylen, dolestan, felben, fenylhist, halbmond, rohydra, sedopretten, valdrene, wehydryl. hydrochloride •capsules, 25 & 50 mg; injection (syringes & ampuls); elixir, 50 mg (single adult doses). hydrochloride, from table
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 actifed sinus nighttime
 alledryl
 allergina
 allergival
 ambenyl
 antitussive
 bagodryl
 bayer select night time pain relief
 beldin
 belix
 bena-fedrin
 benacine
 benadril hydrochloride
 benadryl
 bendylate
 benzantin
 benzehist
O-benzhydryldimethylaminoethanol hydrochloride
2-benzhydryloxy-N,N-dimethyl-ethanamine
2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
2-(benzhydryloxy)-N,N-dimethylethanamine hydrochloride
2-(benzhydryloxy)-N,N-dimethylethylamine hydrochloride
2-(benzhydryloxy)-N,N-dimethylethylamine, hydrochloride
 caladryl
 carphenex
 cathejell
 contac day & night allergy sinus night caplets
 contac day & night cold/flu night caplets
 dabylen
 denydryl
 dibondrin
 difenhydramine hydrochloride
 dimedrol
a-(2-dimethylaminoethoxy)diphenylmethane hydrochloride
b-dimethylaminoethyl benzhydryl ether hydrochloride
 diphenhydramine hydrochloride
 diphenhydraminehydrochloride
 diphenylhydramine hydrochloride
2-diphenylmethoxy-N,N-dimethylethanamine hydrochloride
2-diphenylmethoxy-N,N-dimethylethylamine hydrochloride
2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride
2-(diphenylmethoxy)-N,N-dimethylethanaminium chloride
[2-(diphenylmethoxy)ethyl]dimethylamine hydrochloride
[2-(diphenylmethoxy)ethyl]dimethylamine, chloride
N-(2-diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine hydrochloride
 dobacen hydrochloride
 dolestan
 eldadryl
 ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1)
 ethylamine, N,N-dimethyl-2-(diphenylmethoxy)-, hydrochloride
 felben
 fenylhist
 halbmond
 histacyl
 midol pm night time formula
 noctomin
 paradryl
 prodryl
 resmin
 restamin
 sedopretten
 sekundal-D
 silphen
 sleep-eze-3
 syntedril
 tylenol allergy sinus night time caplets
 tylenol cold night time liquid
 tylenol flu night time gelcaps
 tylenol flu night time powder
 tylenol pm tablets/caplets
 valdrene
 vicks formula 44
 wehydryl
 ziradryl
 

Articles:

PubMed:Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions.
PubMed:Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis.
PubMed:Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration.
PubMed:A composite polyelectrolytic matrix for controlled oral drug delivery.
PubMed:Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media.
PubMed:Prescription writing trends of antihistamines at the university health centre.
PubMed:Black ant stings caused by Pachycondyla sennaarensis: a significant health hazard.
PubMed:The comparison of diphenhydramine HCl and Nedocromil sodium in prevention of abdominal postoperative adhesion formation in rat models: an experimental study.
PubMed:Microwave-assisted solvent extraction of solid matrices and subsequent detection of pharmaceuticals and personal care products (PPCPs) using gas chromatography-mass spectrometry.
PubMed:Temperature/Humidity sensitivity of sustained-release formulations containing Kollidon SR.
PubMed:A study of the effects of curing and storage conditions on controlled release diphenhydramine HCl pellets coated with Eudragit NE30D.
PubMed:Diphenhydramine and hyaluronic acid derivatives reduce adnexal adhesions and prevent tubal obstructions in rats.
PubMed:Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets.
PubMed:Study of crystallization of endogenous surfactant in Eudragit NE30D-free films and its influence on drug-release properties of controlled-release diphenhydramine HCl pellets coated with Eudragit NE30D.
PubMed:Childhood serum sickness: a case report.
PubMed:Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions.
PubMed:Effects of formulation variables and post-compression curing on drug release from a new sustained-release matrix material: polyvinylacetate-povidone.
PubMed:Indirect atomic absorption determination of atropine, diphenhydramine, tolazoline, and levamisole based on formation of ion-associates with potassium tetraiodometrcurate.
PubMed:Atomic emission spectrometric determination of ephedrine, cinchonine, chlorpheniramine, atropine and diphenhydramine based on formation of ion associates with ammonium reineckate.
PubMed:Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography.
PubMed:Prevention and treatment of dichlorvos-induced toxicosis in mice by diphenhydramine.
PubMed:[An animal model for screening of antiallergic and antipruritic drugs].
PubMed:Differential illness intrusiveness associated with sleep-promoting medications.
PubMed:Inhibition of neutral endopeptidase potentiates compound 48/80-induced constriction of guinea-pig tracheal smooth muscle.
PubMed:Comparison of the sedative effectiveness of two pharmacological regimens.
PubMed:Mechanism of drug release from an acrylic polymer-wax matrix tablet.
PubMed:[4-Aminopyridine-induced licking response and histamine liberation in mice].
PubMed:Phosphoramidon modulates effects of the 5-lipoxygenase inhibition on anaphylactic contraction of the guinea pig trachea.
PubMed:Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4.
PubMed:Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing.
PubMed:Spectrophotometric determination of ephedrine HCl, cinchonine HCl, chlorpheniramine maleate, atropine sulphate and diphenhydramine HCl by solvent extraction of reineckate complexes.
PubMed:Effect of diphenhydramine on organophosphorus insecticide toxicity in mice.
PubMed:Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals.
PubMed:Antihistamines reverse blood-ocular barrier breakdown in experimental diabetes.
PubMed:Medical emergencies aboard commercial aircraft.
PubMed:Tagamet-induced acute dystonia.
PubMed:An extract of rat submandibular glands activates platelets and enhances cutaneous vascular permeability in rats and guinea pigs.
PubMed:Superoxide anion generation during airway anaphylaxis.
PubMed:Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
PubMed:Supra-additive toxic interaction of nicotine with antihistamines, and enhancement by the proconvulsant pentylenetetrazole.
PubMed:The contractile properties of wound granulation tissue.
PubMed:The pharmacokinetics of meprobamate following its oral and rectal administration as a series of combinations with diphenhydramine, acetylsalicylic acid, codeine and pentaerythritol tetranitrate.
PubMed:Diphenhydramine: kinetics and psychomotor effects in elderly women.
PubMed:Effects of tricyclic antidepressant and anticholinergic drugs on fixed-interval responding in the squirrel monkey.
PubMed:Stimulant actions of histamine H1 antagonists on operant behavior in the squirrel monkey.
PubMed:Effect of anti-parkinsonism drugs on gastric emptying and intestinal transit in the rat.
PubMed:Suppression of histamine-induced pruritus by three antihistaminic drugs.
PubMed:Teratogenesis studies with diphenhydramine HCl.
PubMed:Effect of chlorpromazine, WY 1246 Melleril, diphenhydramine HCl (benadryl) and tyramine on barbital anesthesia.
PubMed:Treatment of leg cramps during pregnancy: use of diphenhydramine HCl.
PubMed:The effect of diphenhydramine HCL (benadryl HCL) on skeletal muscle.
PubMed:The influence of diphenhydramine HCl (benadryl) on apomorphine-induced emesis in dogs.
 
Notes:
a histamine h1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. it has some undesired antimuscarinic and sedative effects.
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