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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 343.70 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000069 mmHg @ 25.00 °C. (est) |
| Flash Point: | 215.00 °F. TCC ( 101.50 °C. ) (est)
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| logP (o/w): | 3.662 (est) |
| Soluble in: |
| | water, 602.4 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-child TDLo 12500 ug/kg
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pediatrics. Vol. 90, Pg. 1017, 1977.
intravenous-dog LD50 24 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 227, 1947.
intraperitoneal-guinea pig LD50 75 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 83, Pg. 120, 1945.
oral-guinea pig LD50 280 mg/kg
Journal of Allergy. Vol. 27, Pg. 57, 1956.
intravenous-hamster LD50 18 mg/kg
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949.
intraperitoneal-mammal (species unspecified) LD50 80 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 328, 1953.
oral-man TDLo 10714 ug/kg
AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
American Journal of Emergency Medicine. Vol. 4, Pg. 369, 1986.
intraperitoneal-mouse LD50 56 mg/kg
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 112, Pg. 318, 1954.
intravenous-mouse LD50 20 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
oral-mouse LD50 164 mg/kg
Drugs in Japan Vol. -, Pg. 550, 1995.
intravenous-rabbit LD50 10 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 150, 1945.
intraperitoneal-rat LD50 82 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 250, 1951.
intravenous-rat LD50 35 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 2769, 1984.
oral-rat LD50 500 mg/kg
Drugs in Japan Vol. 6, Pg. 334, 1982.
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| Dermal Toxicity: |
skin-child TDLo 60 mg/kg/6H-I
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: ATAXIA
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Clinical Pediatrics Vol. 25, Pg. 163, 1986.
subcutaneous-guinea pig LD50 40 mg/kg
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
subcutaneous-mouse LD50 99200 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 33, 1958.
subcutaneous-rat LD50 201 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 261, 1961.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for diphenhydramine HCL usage levels up to: | | | not for fragrance use.
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| Recommendation for diphenhydramine HCL flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 8980 |
| Pubchem (sid): | 134975097 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07784 |
| HMDB (The Human Metabolome Database): | HMDB01927 |
| Export Tariff Code: | 2922.19.7000 |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•hydrochloride...bax, benadryl, benocten, benzehist, dabylen, dolestan, felben, fenylhist, halbmond, rohydra, sedopretten, valdrene, wehydryl. hydrochloride
•capsules, 25 & 50 mg; injection (syringes & ampuls); elixir, 50 mg (single adult doses). hydrochloride, from table
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | actifed sinus nighttime | | | alledryl | | | allergina | | | allergival | | | ambenyl | | | antitussive | | | bagodryl | | | bayer select night time pain relief | | | beldin | | | belix | | | bena-fedrin | | | benacine | | | benadril hydrochloride | | | benadryl | | | bendylate | | | benzantin | | | benzehist | | O- | benzhydryldimethylaminoethanol hydrochloride | | 2- | benzhydryloxy-N,N-dimethyl-ethanamine | | 2- | benzhydryloxy-N,N-dimethylethanamine;hydrochloride | | 2-( | benzhydryloxy)-N,N-dimethylethanamine hydrochloride | | 2-( | benzhydryloxy)-N,N-dimethylethylamine hydrochloride | | 2-( | benzhydryloxy)-N,N-dimethylethylamine, hydrochloride | | | caladryl | | | carphenex | | | cathejell | | | contac day & night allergy sinus night caplets | | | contac day & night cold/flu night caplets | | | dabylen | | | denydryl | | | dibondrin | | | difenhydramine hydrochloride | | | dimedrol | | a-(2- | dimethylaminoethoxy)diphenylmethane hydrochloride | | b- | dimethylaminoethyl benzhydryl ether hydrochloride | | | diphenhydramine hydrochloride | | | diphenhydraminehydrochloride | | | diphenylhydramine hydrochloride | | 2- | diphenylmethoxy-N,N-dimethylethanamine hydrochloride | | 2- | diphenylmethoxy-N,N-dimethylethylamine hydrochloride | | 2-( | diphenylmethoxy)-N,N-dimethylethanamine hydrochloride | | 2-( | diphenylmethoxy)-N,N-dimethylethanaminium chloride | | [2-( | diphenylmethoxy)ethyl]dimethylamine hydrochloride | | [2-( | diphenylmethoxy)ethyl]dimethylamine, chloride | | N-(2- | diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride | | 2-[( | diphenylmethyl)oxy]-N,N-dimethylethanamine hydrochloride | | | dobacen hydrochloride | | | dolestan | | | eldadryl | | | ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1) | | | ethylamine, N,N-dimethyl-2-(diphenylmethoxy)-, hydrochloride | | | felben | | | fenylhist | | | halbmond | | | histacyl | | | midol pm night time formula | | | noctomin | | | paradryl | | | prodryl | | | resmin | | | restamin | | | sedopretten | | | sekundal-D | | | silphen | | | sleep-eze-3 | | | syntedril | | | tylenol allergy sinus night time caplets | | | tylenol cold night time liquid | | | tylenol flu night time gelcaps | | | tylenol flu night time powder | | | tylenol pm tablets/caplets | | | valdrene | | | vicks formula 44 | | | wehydryl | | | ziradryl |
Articles:
| PubMed:Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions. |
| PubMed:Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis. |
| PubMed:Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration. |
| PubMed:A composite polyelectrolytic matrix for controlled oral drug delivery. |
| PubMed:Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media. |
| PubMed:Prescription writing trends of antihistamines at the university health centre. |
| PubMed:Black ant stings caused by Pachycondyla sennaarensis: a significant health hazard. |
| PubMed:The comparison of diphenhydramine HCl and Nedocromil sodium in prevention of abdominal postoperative adhesion formation in rat models: an experimental study. |
| PubMed:Microwave-assisted solvent extraction of solid matrices and subsequent detection of pharmaceuticals and personal care products (PPCPs) using gas chromatography-mass spectrometry. |
| PubMed:Temperature/Humidity sensitivity of sustained-release formulations containing Kollidon SR. |
| PubMed:A study of the effects of curing and storage conditions on controlled release diphenhydramine HCl pellets coated with Eudragit NE30D. |
| PubMed:Diphenhydramine and hyaluronic acid derivatives reduce adnexal adhesions and prevent tubal obstructions in rats. |
| PubMed:Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets. |
| PubMed:Study of crystallization of endogenous surfactant in Eudragit NE30D-free films and its influence on drug-release properties of controlled-release diphenhydramine HCl pellets coated with Eudragit NE30D. |
| PubMed:Childhood serum sickness: a case report. |
| PubMed:Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. |
| PubMed:Effects of formulation variables and post-compression curing on drug release from a new sustained-release matrix material: polyvinylacetate-povidone. |
| PubMed:Indirect atomic absorption determination of atropine, diphenhydramine, tolazoline, and levamisole based on formation of ion-associates with potassium tetraiodometrcurate. |
| PubMed:Atomic emission spectrometric determination of ephedrine, cinchonine, chlorpheniramine, atropine and diphenhydramine based on formation of ion associates with ammonium reineckate. |
| PubMed:Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography. |
| PubMed:Prevention and treatment of dichlorvos-induced toxicosis in mice by diphenhydramine. |
| PubMed:[An animal model for screening of antiallergic and antipruritic drugs]. |
| PubMed:Differential illness intrusiveness associated with sleep-promoting medications. |
| PubMed:Inhibition of neutral endopeptidase potentiates compound 48/80-induced constriction of guinea-pig tracheal smooth muscle. |
| PubMed:Comparison of the sedative effectiveness of two pharmacological regimens. |
| PubMed:Mechanism of drug release from an acrylic polymer-wax matrix tablet. |
| PubMed:[4-Aminopyridine-induced licking response and histamine liberation in mice]. |
| PubMed:Phosphoramidon modulates effects of the 5-lipoxygenase inhibition on anaphylactic contraction of the guinea pig trachea. |
| PubMed:Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. |
| PubMed:Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing. |
| PubMed:Spectrophotometric determination of ephedrine HCl, cinchonine HCl, chlorpheniramine maleate, atropine sulphate and diphenhydramine HCl by solvent extraction of reineckate complexes. |
| PubMed:Effect of diphenhydramine on organophosphorus insecticide toxicity in mice. |
| PubMed:Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals. |
| PubMed:Antihistamines reverse blood-ocular barrier breakdown in experimental diabetes. |
| PubMed:Medical emergencies aboard commercial aircraft. |
| PubMed:Tagamet-induced acute dystonia. |
| PubMed:An extract of rat submandibular glands activates platelets and enhances cutaneous vascular permeability in rats and guinea pigs. |
| PubMed:Superoxide anion generation during airway anaphylaxis. |
| PubMed:Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. |
| PubMed:Supra-additive toxic interaction of nicotine with antihistamines, and enhancement by the proconvulsant pentylenetetrazole. |
| PubMed:The contractile properties of wound granulation tissue. |
| PubMed:The pharmacokinetics of meprobamate following its oral and rectal administration as a series of combinations with diphenhydramine, acetylsalicylic acid, codeine and pentaerythritol tetranitrate. |
| PubMed:Diphenhydramine: kinetics and psychomotor effects in elderly women. |
| PubMed:Effects of tricyclic antidepressant and anticholinergic drugs on fixed-interval responding in the squirrel monkey. |
| PubMed:Stimulant actions of histamine H1 antagonists on operant behavior in the squirrel monkey. |
| PubMed:Effect of anti-parkinsonism drugs on gastric emptying and intestinal transit in the rat. |
| PubMed:Suppression of histamine-induced pruritus by three antihistaminic drugs. |
| PubMed:Teratogenesis studies with diphenhydramine HCl. |
| PubMed:Effect of chlorpromazine, WY 1246 Melleril, diphenhydramine HCl (benadryl) and tyramine on barbital anesthesia. |
| PubMed:Treatment of leg cramps during pregnancy: use of diphenhydramine HCl. |
| PubMed:The effect of diphenhydramine HCL (benadryl HCL) on skeletal muscle. |
| PubMed:The influence of diphenhydramine HCl (benadryl) on apomorphine-induced emesis in dogs. |
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a histamine h1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. it has some undesired antimuscarinic and sedative effects.
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3D/inchi