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Category:solvents/deluents for flavor and/or fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.07600 to 1.08200 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 8.953 to 9.003
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| Refractive Index: | 1.40700 to 1.41300 @ 20.00 °C.
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| Melting Point: | -41.00 to -40.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 185.70 °C. @ 760.00 mm Hg
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| Boiling Point: | 113.00 to 114.00 °C. @ 50.00 mm Hg
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| Vapor Pressure: | 0.414000 mmHg @ 25.00 °C. |
| Vapor Density: | 5.03 ( Air = 1 ) |
| Flash Point: | 168.00 °F. TCC ( 75.56 °C. )
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| logP (o/w): | 0.560 |
| Soluble in: |
| | alcohol | | | water, 3.60E+04 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 22 - Harmful if swallowed.
R 36 - Irritating to eyes.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 25 - Avoid contact with eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/39 - Wear suitable clothing and eye/face protection.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 1600 mg/kg
(Patty, 1963)
oral-mouse LD50 2000 mg/kg
BEHAVIORAL: ANTIPSYCHOTIC
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(5), Pg. 87, 1981.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | solvents/deluents for flavor and/or fragrance agents |
| Recommendation for diethyl oxalate usage levels up to: | | | not for fragrance use.
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| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.0012 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 3900 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 7.00000 | 35.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 5.00000 | 25.00000 |
| Edible ices, including sherbet and sorbet (03.0): | 10.00000 | 50.00000 |
| Processed fruit (04.1): | 7.00000 | 35.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 10.00000 | 50.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 5.00000 | 25.00000 |
| Bakery wares (07.0): | 10.00000 | 50.00000 |
| Meat and meat products, including poultry and game (08.0): | 2.00000 | 10.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 2.00000 | 10.00000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 5.00000 | 25.00000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 10.00000 | 50.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 5.00000 | 25.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 10.00000 | 50.00000 |
| Ready-to-eat savouries (15.0): | 20.00000 | 100.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 5.00000 | 25.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
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Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
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Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009)
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):95-92-1 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :7268 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 2525 |
| WGK Germany:1 |
| diethyl oxalate |
| Chemidplus:0000095921 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:RO2800000 for cas# 95-92-1 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | chelating agents |
| | hair conditioning |
| | plasticisers |
| | solvents |
Occurrence (nature, food, other): note
Synonyms:
| | diethyl ethane dioate | | | diethyl ethane-1,2-dioate | | | diethyl ethanedioate | | | diethyloxalate | | | ethane dioic acid diethyl ester | | | ethanedioic acid diethyl ester | | | ethanedioic acid, diethyl ester | | | ethyl oxalate | | | oxalic acid diethyl ester | | | oxalic acid, diethyl ester | | | oxalic ether |
Articles:
| PubMed:β-Pyrazino-fused tetrarylporphyrins. |
| PubMed:3,4-Dihydroxy-1,6-bis(4-methoxyphenyl)hexa-2,4-diene-1,6-dione, its 4-methylphenyl analogue, and a potassium salt of 2-hydroxy-4-(4-methoxyphenyl)-4-oxobut-2-enoic acid. |
| PubMed:The effect of fluorine atom on the synthesis and composition of gametocidal ethyl oxanilates. |
| PubMed:Reactivity of 2-ethoxyquinazolin- 4-yl hydrazine and its use in synthesis of novel quinazoline derivatives of antimicrobial activity. |
| PubMed:Transesterification of diethyl oxalate with phenol over sol-gel MoO(3)/TiO(2) catalysts. |
| PubMed:New modulated design and synthesis of chiral CuII/SnIV bimetallic potential anticancer drug entity: in vitro DNA binding and pBR322 DNA cleavage activity. |
| PubMed:Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents. |
| PubMed:Xylitol production from DEO hydrolysate of corn stover by Pichia stipitis YS-30. |
| PubMed:Mono- and dicarbonyl-bridged tricyclic heterocyclic acceptors: synthesis and electronic properties. |
| PubMed:(Z)-Ethyl 2-oxo-3-(1,2-dihydroquinolin-2-yl-idene)propano-ate. |
| PubMed:A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones. |
| PubMed:Conformational properties, chiroptical spectra, and molecular self-assembly of 2,3-piperazinodiones and their dithiono analogues. |
| PubMed:Host-guest interaction in a thiourea-dimethyl oxalate (2/1) complex at 300 and 100 K. |
| PubMed:Synthesis of highly substituted enantiopure piperazines and ketopiperazines from vicinal N-sulfinyl diamines. |
| PubMed:Practical formal total synthesis of (rac)- and (S)-camptothecin. |
| PubMed:Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives. |
| PubMed:Highly efficient preparation of aryl beta-diketo acids with tert-butyl methyl oxalate. |
| PubMed:A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes. |
| PubMed:Synthesis and quantitative structure-activity relationships of oxanilates as chemical hybridizing agents for wheat (Triticum aestivum L.). |
| PubMed:Efficient synthesis and hydrolysis of cyclic oxalate esters of glycols. |
| PubMed:Synthesis of heterocyclic quinones containing bridgehead nitrogen atom from 2-aminonaphtho[2,3-d]thiazole-4,9-dione. |
| PubMed:Novel steroid spiro enones: condensation of prednisolone derivatives with diethyl oxalate. |
| PubMed:Synthesis and biodistribution of new oxo and nitrido 99mTc complexes with asymmetrical potentially dianionic or trianionic tetradentate SNNO ligands derived from methyl-2-aminocyclopentene-1-dithiocarboxylic acid. |
| PubMed:Reactions of 3-aminopyrazole derivatives with cyanothioacetamide and its derivatives: Synthesis and reactions of several new pyrazole and pyrazole[3,2-b]pyrimidine derivatives. |
| PubMed:Synthesis of biologically active [2.2]paracyclophanes. |
| PubMed:Reactions of 4-aryl-1-hydrazinophthalazines with carbonyl compounds. |
| PubMed:cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-phenyl-2H-pyrazino[2,1-a] isoquinoline: a new atypical antidepressant. |
| PubMed:New cyclopenta[a]naphthalene derivatives. Synthesis of 2-(carbamylmethyl)-8-hydroxy-3H-cyclopental[a]naphthalene as a possible deoxyribonucleic acid binding agent. |
| PubMed:[Chrysotile fiber count in asbestos-cement board plants (author's transl)]. |
| PubMed:[Reaction of ketone-group-containing compounds with diethyl oxalate and analytic application of the reaction. 3. Alicyclic ketones and compounds containing more than one ketone group]. |
| PubMed:[Reactions of gamma-keto-alcohols with diethyl oxalate (author's transl)]. |
| PubMed:Analysis of steroids. XVII. A differential spectrophotometric variant of the diethyl oxalate method for the determination of ketosteroid contaminants. |
| PubMed:[Reaction of diethyl oxalate with compounds containing a ketone group and analytical applications of this reaction. II. Aliphatic and aromatic ketones]. |
| PubMed:[Reaction of diethyl oxalate with compounds containing a ketone group and analytical application of this reaction. I. Determination of optimum parameters for the reaction]. |
| PubMed:Diethyl oxalate as new reagent for spectrophotometric determination of ketosteroids. |
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3D/inchi