EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cytochrome C
hematin-protein

Supplier Sponsors

CAS Number: 9007-43-6Picture of molecule3D/inchi
Other(deleted CASRN):37219-70-8
ECHA EINECS - REACH Pre-Reg:232-700-9
MDL:MFCD00130890
Molecular Weight:884.90264000
Formula:C42 H52 Fe N8 O6 S2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cytochrome C Iron content >0.43% (
George Uhe Company
Cytochrome C
Glentham Life Sciences
Cytochrome C, from equine heart
Pangaea Sciences
Cytochrome C injectable
Sigma-Aldrich: Sigma
For experimental / research use only.
Cytochrome C from bovine heart ≥95% based on Mol. Wt. 12,327 basis
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 > 3000 mg/kg
Drugs in Japan Vol. 6, Pg. 461, 1982.

intraperitoneal-rat LD50 6250 mg/kg
Toksikologicheskii Vestnik. Vol. (4), Pg. 40, 1994.

oral-rat LDLo 10000 mg/kg
Toksikologicheskii Vestnik. Vol. (4), Pg. 40, 1994.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for cytochrome C usage levels up to:
 not for fragrance use.
 
Recommendation for cytochrome C flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9007-43-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :439171
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
3-[7,12-bis[1-[2-amino-3-(methylamino)-3-oxopropyl]sulfanylethyl]-18-(2-carboxyethyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoicacid;iron(2+)
Chemidplus:0009007436
RTECS:HA5365000 for cas# 9007-43-6
 
References:
 3-[7,12-bis[1-[2-amino-3-(methylamino)-3-oxopropyl]sulfanylethyl]-18-(2-carboxyethyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoicacid;iron(2+)
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):439171
Pubchem (sid):135323767
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C00524
HMDB (The Human Metabolome Database):HMDB12920
FooDB:FDB029208
Export Tariff Code:2933.90.9500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 biological additives
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
3-[7,12-bis[1-[2-amino-3-(methylamino)-3-oxopropyl]sulfanylethyl]-18-(2-carboxyethyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoicacid;iron(2+)
 cytorest
 ferricytochrome C
 ferrocytochrome C
 hematin-protein
 horse heart cytochrome C
 horse-cytochrome C
 landrax
 myohematin
 

Articles:

PubMed:Changes in the physicochemical and sensory characteristics in raw and grilled ovine meat.
PubMed:Isomenthone protects human dermal fibroblasts from TNF-α-induced death possibly by preventing activation of JNK and p38 MAPK.
PubMed:Oxygen consumption rate of permeabilized cells and isolated mitochondria from pork M. masseter and liver examined fresh and after freeze-thawing at different pH values.
PubMed:Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade.
PubMed:Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.
PubMed:Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.
 
Notes:
cytochromes of the c type that are found in eukaryotic mitochondria. they serve as redox intermediates that accept electrons from mitochondrial electron transport complex iii and transfer them to mitochondrial electron transport complex iv. Cytochrome c is a highly conserved protein across the spectrum of species, found in plants, animals, and many unicellular organisms. This, along with its small size (molecular weight about 12,000 daltons), makes it useful in studies of cladistics. Its primary structure consists of a chain of about 100 amino acids. Many higher order organisms possess a chain of 104 amino acids.; Cytochrome c, or cyt c (horse heart: PDB 1HRC) is a small heme protein found loosely associated with the inner membrane of the mitochondrion. It belongs to the cytochrome c family of proteins. Cytochrome c is a highly soluble protein, unlike other cytochromes, with a solubility of about 100g/L and is an essential component of the electron transport chain, where it carries one electron. It is capable of undergoing oxidation and reduction, but does not bind oxygen. It transfers electrons between Complexes III and IV.; The cytochrome c molecule has been studied for the glimpse it gives into evolutionary biology. Both chickens and turkeys have identical sequence homology (amino acid for amino acid), whereas ducks possess molecules differing by one amino acid. Similarly, both humans and chimpanzees have the identical molecule, while rhesus monkeys share all but one of the amino acids: the 66th amino acid is isoleucine in the former and threonine in the latter. Pigs, cows and sheep also share identical cytochrome c molecules. [HMDB]
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