EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cytidine
4-amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone

Supplier Sponsors

CAS Number: 65-46-3Picture of molecule3D/inchi
Other(deleted CASRN):4395-95-3
ECHA EINECS - REACH Pre-Reg:200-610-9
FDA UNII:5CSZ8459RP
Nikkaji Web:J4.837B
Beilstein Number:089173
MDL:MFCD00006545
XlogP3:-2.10 (est)
Molecular Weight:243.21961000
Formula:C9 H13 N3 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 230.50 °C. @ 760.00 mm Hg
Boiling Point: 545.68 °C. @ 760.00 mm Hg (est)
Flash Point: 543.00 °F. TCC ( 283.80 °C. ) (est)
logP (o/w): -1.808 (est)
Soluble in:
 water, 1.757e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
skin protecting agents
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Cytidine 98%
BOC Sciences
For experimental / research use only.
Cytidine 98% by HPLC
Changzhou Longo Chemical
Cytidine
Dow Chemical
Cytidine
George Uhe Company
Cytidine
Glentham Life Sciences
Cytidine
Maypro Industries
Cytidine
Sigma-Aldrich: Aldrich
For experimental / research use only.
Cytidine 99%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 2700 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Russian Pharmacology and Toxicology Vol. 40, Pg. 66, 1977.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for cytidine usage levels up to:
 not for fragrance use.
 
Recommendation for cytidine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):65-46-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6175
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Chemidplus:0000065463
EPA/NOAA CAMEO:hazardous materials
RTECS:UW7370000 for cas# 65-46-3
 
References:
 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:65-46-3
Pubchem (cid):6175
Pubchem (sid):134972626
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00475
HMDB (The Human Metabolome Database):HMDB00089
FooDB:FDB021809
YMDB (Yeast Metabolome Database):YMDB00051
Export Tariff Code:2934.90.5000
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone
4-amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone
 cytosine riboside
 cytosine-1b-D-ribofuranoside
1-(b-D-ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
1-b-D-ribofuranosylcytosine
1-b-D-ribosyl-cytosine
 zytidin
 

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PubMed:Functional aspects of fish lymphocytes.
PubMed:Some mechanisms of FLIP expression in inhibition of HIV-1 replication in Jurkat cells, CD4+ T cells and PBMCs.
PubMed:Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population.
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PubMed:Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes.
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PubMed:Identification of Ser424 as the protein kinase A phosphorylation site in CTP synthetase from Saccharomyces cerevisiae.
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PubMed:Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae.
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PubMed:The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants.
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PubMed:Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by CTP.
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PubMed:Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae.
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PubMed:Regulation of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae by CDP-diacylglycerol.
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PubMed:Increase of survival time in experimental hypoxia by cytidine diphosphate choline.
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PubMed:Rates of rat liver RNA degradation in vivo as determined from cytidine release during brief cyclic perfusion in situ.
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PubMed:Purification, properties, and genetic location of Escherichia coli cytidine 5'-monophosphate N-acetylneuraminic acid synthetase.
PubMed:Effect of dietary nucleotides on the plasma fatty acids in at-term neonates.
PubMed:[Nutritive value of dietary ribonucleic acid and its nucleosides in growing rats on a diet deficient in nonessential amino acid nitrogen. 4. Effect of the pyrimidine nucleosides cytidine and uridine on the composition of the body mass and on nitrogen metabolism].
PubMed:Nucleoside and oxypurine homeostasis in adult rabbit cerebrospinal fluid and plasma.
PubMed:Effect of fasting on the metabolism of cytidine nucleotides in the liver of intact and alpha-hexachlorocyclohexane-treated rats.
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PubMed:The uptake of pyrimidine nucleosides in Tetrahymena. I. Uridine.
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Notes:
a pyrimidine nucleoside that is composed of the base cytosine linked to the five-carbon sugar d-ribose. Cytidine is a nucleoside that is composed of the base cytosine linked to the five-carbon sugar D-ribose. Cytidine is a pyrimidine that besides being incorporated into nucleic acids, can serve as substrate for the salvage pathway of pyrimidine nucleotide synthesis; as precursor of the cytidine triphosphate (CTP) needed in the phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthetic pathway. These variations probably reflect the species differences in cytidine deaminase, the enzyme that converts cytidine to uridine in the body. The transports of cytidine into the brain's extracellular fluid, and then into neurons and glia, are essential prerequisites for cytidine to be utilized in brain. An efficient mechanism mediating the brain uptake of circulating cytidine has not yet been demonstrated. The biosynthesis of PC, the most abundant phosphatide in the brain, via the Kennedy pathway requires phosphocholine and cytidine triphosphate (CTP), a cytidine nucleotide, which is involved in the rate-limiting step. The enzyme that converts CTP to endogenous CDP-choline (CTP: phosphocholine cytidylyltransferase) is unsaturated at physiological brain CTP levels. APOBEC is a family of enzymes has been discovered with the ability to deaminate cytidines on RNA or DNA. The human apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G, or hA3G) protein, provides cells with an intracellular antiretroviral activity that is associated with the hypermutation of viral DNA through cytidine deamination. Indeed, hA3G belongs to a family of vertebrate proteins that contain one or two copies of a signature sequence motif unique to cytidine deaminases (CTDAs). (PMID: 16769123, 15780864, 16720547) [HMDB]
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