EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sodium citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:1)

Supplier Sponsors

Name:sodium 2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate
CAS Number: 18996-35-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:242-734-6
FDA UNII: 68538UP9SE
MDL:MFCD00013067
Molecular Weight:214.10595928
Formula:C6 H7 Na O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:buffering agents, sequestrants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1751 Sodium citrate View - review
EU SANCO Sodium citrates View - review
JECFA Food Additive: Sodium Dihydrogen Citrate
GSFA Codex: Sodium dihydrogen citrate (331(i))
DG SANTE Food Additives:sodium citrate
FDA Mainterm (IAUFC):18996-35-5 ; MONOSODIUM CITRATE
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: buffering agents
 
Suppliers:
Austrade
Citric Acid Ester (Sodium Citrate)
Flavor: characteristic
In solid form (flakes), based on fully hydrogenated palm oil for low fat margarines, meat emulsions, or seasoning blends. In liquid form, based on sunflower oil for flavors and low fat margarines.
BOC Sciences
For experimental / research use only.
Sodium dihydrogencitrate
Cargill, Inc.
Sodium citrate
Charkit Chemical
MONOSODIUM CITRATE
Covalent Chemical
Sodium Citrate
Farbest-Tallman Foods
Sodium Citrate Solution
Global Calcium
MonoSodium Citrate
Jungbunzlauer Suisse
Monosodium Citrate
Flavor: sour
Monosodium citrate is a monobasic salt of citric acid and is produced by partial neutralization of citric acid with a high purity sodium source and subsequent crystallization. It is supplied as anhydrous material. As partially neutralized salt it occupies an intermediate position between citric acid and the neutral or weakly alkaline trisodium citrate. Monosodium citrate is used if a buffering effect is required or if citric acid is considered to be too aggressive for the formulation. Monosodium citrate is also less hygroscopic than citric acid, thus less prone to caking and preferred in critical formulations such as dry blends, instant preparations or tablets.
Kraft Chemical
Sodium Citrate
Northwestern Extract
Sodium Citrate FCC
Prinova
Sodium Citrate USP
Qingdao Dacon Trading
Sodium Citrate
Santa Cruz Biotechnology
For experimental / research use only.
Sodium citrate monobasic ≥99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium citrate monobasic purum p.a., anhydrous, ≥99.0% (T)
Tate & Lyle
Sodium Citrate
Wedor Corporation
SODIUM CITRATE
Zhong Ya Chemical
Sodium Citrate
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 1348 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intravenous-rabbit LD50 379 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intravenous-mouse LD50 49 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intraperitoneal-mouse LD50 1635 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
buffering agents, sequestrants
Recommendation for sodium citrate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium citrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):18996-35-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23662352
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
sodium 2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate
Chemidplus:0018996355
RTECS:GE7950000 for cas# 18996-35-5
 
References:
 sodium 2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:18996-35-5
Pubchem (cid):23662352
Pubchem (sid):134992229
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB020550
Export Tariff Code:2918.15.1000
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 citric acid monosodium salt
 citric acid, monosodium salt
 citrofluyl
1,2,3-propanetricarboxylic acid, 2-hydroxy-, monosodium salt
1,2,3-propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:1)
 sodium 2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate
monosodium citrate
 sodium dihydrogen citrate
monosodium dihydrogen citrate
 

Articles:

PubMed:No effect of protein coingestion on exogenous glucose oxidation during exercise.
PubMed:Application of multivariate analysis to the effects of additives on chemical and sensory quality of stored coffee brew.
PubMed:Marination of turkey breast fillets to control the growth of Listeria monocytogenes and improve meat quality in deli loaves.
PubMed:Effects of pre-rigor injection of sodium citrate or acetate, or post-rigor injection of phosphate plus salt on post-mortem glycolysis, pH, and pork quality attributes.
PubMed:[Intermediate moisture foods: polysaccharide and protein gels].
 
Notes:
Preservative Monosodium citrate, or sodium dihydrogen citrate, is an acid salt with the chemical formula NaH2C6H5O7, or C3H4OH(COOH)2COONa. Since it has two remaining open spots on the citrate anion, it is used as a relatively strong sequestrant. It is used to prevent platelet clumping in blood samples. It is one of the 3 citric acid salts. (Wikipedia) Used in food processing as an emulsifying agent, pH control agent, colour control agent, flavouring agent and modifier. Used in conjunction with ascorbate or erythorbate derivs. as a cure accelerator in processed meat products Trisodium citrate, sometimes referred to simply as sodium citrate, possesses a saline, mildly tart flavor. Sodium citrate is chiefly used as a food additive E331, usually for flavor or as a preservative. Sodium citrate is employed as a flavoring agent in certain varieties of club soda. Sodium citrate is common as an ingredient in Bratwurst, lemon-lime and citrus soft drinks, such as Ting, Chinotto, and some Ocean Spray juices, contributing to their tart tastes, and can also be found in such energy drinks as Rockstar and Red Bull. (Wikipedia)
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