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Category:indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline flakes (est) |
| Assay: | 98.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 153.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 400.84 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | 220.00 °C. @ 4.00 mm Hg
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| Flash Point: | 378.00 °F. TCC ( 192.40 °C. ) (est)
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| logP (o/w): | 3.320 |
| Soluble in: |
| | water, 120 mg/L @ 25 °C (exp) | | | alcohol | | | acetone |
Organoleptic Properties:
| Odor Strength:low |
| Odor Description:at 100.00 %. mild phenolic |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 3250 mg/kg
American Industrial Hygiene Association Journal. Vol. 28, Pg. 301, 1967.
oral-rabbit LD50 2230 mg/kg
American Industrial Hygiene Association Journal. Vol. 28, Pg. 301, 1967.
oral-mouse LD50 2400 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(7), Pg. 25, 1968.
intraperitoneal-mouse LD50 150 mg/kg
National Technical Information Service. Vol. AD691-490
oral-guinea pig LD50 4000 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(7), Pg. 25, 1968.
oral-mammal (species unspecified) LD50 6500 mg/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 135, 1969.
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| Dermal Toxicity: |
skin-rabbit LD50 3 ml/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
subcutaneous-mouse LDLo 2500 mg/kg
LIVER: FATTY LIVER DEGERATION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 2, Pg. 50, 1961.
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| Inhalation Toxicity: |
inhalation-mouse LC > 1700 mg/m3/2H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 2, Pg. 50, 1961.
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Safety in Use Information:
| Category: | | indirect food additives: adhesives and components of coatings |
| Recommendation for bisphenol A usage levels up to: | | | not for fragrance use.
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| Recommendation for bisphenol A flavor usage levels up to: |
| | not for flavor use.
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| NOEL (No Observed Effect Level): | 25.00 (mg/kg bw per day) |
Safety References:
European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE
View page or View pdf
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Scientific Opinion on Bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of Bisphenol A
View page or View pdf
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Statement on the ANSES reports on bisphenol A
View page or View pdf
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Bisphenol A literature search studies
View page or View pdf
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Meeting with Member State Experts on Bisphenol A
View page or View pdf
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EFSA explains the Safety of Bisphenol A
View page or View pdf
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Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs
View page or View pdf
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Report on the two-phase public consultation on the draft EFSA scientific opinion on bisphenol A (BPA)
View page or View pdf
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Bisphenol A (BPA) hazard assessment protocol
View page or View pdf
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Report on the public consultation on the draft EFSA Bisphenol A (BPA) hazard assessment protocol
View page or View pdf
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Testing the study appraisal methodology from the 2017 Bisphenol A (BPA) hazard assessment protocol
View page or View pdf
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| EPI System: View |
| EPA-Iris:IRIS |
| ClinicalTrials.gov:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA Substance Registry Services (TSCA):80-05-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6623 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol |
| Chemidplus:0000080057 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:80-05-7 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | antimicrobial agents |
| | antioxidants |
Occurrence (nature, food, other): note
Synonyms:
| 2-[4-( | benzyloxy)phenyl]oxirane | | | bisferol A | | 2,2- | di(4-hydroxyphenyl)propane | | 2,2- | di(4-phenylol)propane | | 4,4'- | dihydroxy-2,2-diphenylpropane | | 4,4'- | dihydroxydiphenyl-2,2-propane | | 2,2-(4,4'- | dihydroxydiphenyl)propane | | 2,2-(4,4'- | dihydroxydiphenyl)propane | | 4,4'- | dihydroxydiphenyldimethylmethane | | p,p'- | dihydroxydiphenyldimethylmethane | | 4,4'- | dihydroxydiphenylpropane | | p,p'- | dihydroxydiphenylpropane | | | dimethyl bis(p-hydroxyphenyl)methane | | | dimethylbis(p-hydroxyphenyl)methane | | | dimethylmethylene-p,p'-diphenol | | 4,4'- | dimethylmethylenediphenol | | bis(4- | hydroxyphenyl) dimethylmethane | | 4-[1-(4- | hydroxyphenyl)-1-methylethyl]phenol | | 4-[1-(4- | hydroxyphenyl)-isopropyl]phenol | | bis(4- | hydroxyphenyl)dimethylmethane | | 4-[2-(4- | hydroxyphenyl)propan-2-yl]phenol | | 2,2-bis(4- | hydroxyphenyl)propane | | 2,2-bis(4'- | hydroxyphenyl)propane | | 2,2-bis(p- | hydroxyphenyl)propane | | bis(4- | hydroxyphenyl)propane | | bis(p- | hydroxyphenyl)propane | | 4,4'-(1- | methylethane-1,1-diyl)diphenol | | 4,4'- | methylethylidendbisphenol | | 4,4'-(1- | methylethylidene)bis(phenol) | | 4,4'-(1- | methylethylidene)bisphenol | | 4,4'-bis | phenol A | | | phenol, 4,4'-(1-methylethylidene)bis- | | | phenol, 4,4'-dimethylmethylenedi- | | | phenol, 4,4'-isopropylidenedi- | | 4,4'-( | propan-2-ylidene)diphenol | | 4,4'-(2,2- | propandiyl)diphenol | | 4,4'-( | propane-2,2-diyl)diphenol | | 4,4'- | propane-2,2-diyldiphenol | | | propane, 2,2-bis(p-hydroxyphenyl)- | | 4,4'-(2,2- | propanediyl)diphenol | | 4,4-iso | propylidene diphenol | | 4,4'-iso | propylidene diphenol | | iso | propylidenebis (4-hydroxybenzene) | | iso | propylidenebis(4-hydroxybenzene) | | 4,4'-iso | propylidenebisphenol | | p,p'-iso | propylidenebisphenol | | 4,4-iso | propylidenediphenol | | 4,4'-iso | propylidenediphenol | | p,p'-iso | propylidenediphenol |
Articles:
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3D/inchi