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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 702.06 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 738.00 °F. TCC ( 392.40 °C. ) (est)
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| logP (o/w): | -0.270 (est) |
| Soluble in: |
| | water, 353.1 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 6400 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 66, Pg. 551, 1970.
oral-mouse LD50 > 9000 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 66, Pg. 551, 1970.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for beta-ecdysone usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for beta-ecdysone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :3032482 |
| National Institute of Allergy and Infectious Diseases:Data |
| (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2S,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one |
| Chemidplus:0005289747 |
| RTECS:FZ8060000 for cas# 5289-74-7 |
References:
| | (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2S,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 3032482 |
| Pubchem (sid): | 135269438 |
| Pherobase: | View |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | commisterone | | | crustecdyson | | | crustecdysone | | b- | ecdysone | | | ecdysteron | | | ecdysterone | | (22R)-2-beta,3-beta,14,20,22,25- | hexahydroxy-5-beta-cholest-7-en-6-one | | 20- | hydroxyecdysone | | | polypodine A | | (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14- | trihydroxy-10,13-dimethyl-17-[(2S,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one | | | viticosterone |
Articles:
| PubMed:Phytochemical analysis of Pfaffia glomerata inflorescences by LC-ESI-MS/MS. |
| PubMed:[Chemical constituents from Ajuga nipponensis]. |
| PubMed:Comprehensive study of the phenolics and saponins from Helleborus niger L. Leaves and stems by liquid chromatography/tandem mass spectrometry. |
| PubMed:Ecdysteroids from the flowers of Aerva javanica. |
| PubMed:[Research on chemical constituents of xuefu zhuyu decoction]. |
| PubMed:Beta-ecdysone has bone protective but no estrogenic effects in ovariectomized rats. |
| PubMed:Beneficial effects of beta-Ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats. |
| PubMed:Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR. |
| PubMed:A new phytosterone from Achyranthes bidentata B1. |
| PubMed:Spatially discrete, light-driven protein expression. |
| PubMed:A new phytosterone from Cyanotis arachnoidea. |
| PubMed:Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila. |
| PubMed:Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis. |
| PubMed:Neither enhanced removal of cyclobutane pyrimidine dimers nor strand-specific repair is found after transcription induction of the beta 3-tubulin gene in a Drosophila embryonic cell line Kc. |
| PubMed:Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata. |
| PubMed:[Androgen-like and anabolic action of Antheraea pernyi Guerin-Meneville Pas]. |
| PubMed:[Steroidal saponins from Asparagus filicinus]. |
| PubMed:Induction of apolysis and cuticle formation in female Ornithodoros parkeri (Acari: Argasidae) by hemocoelic injections of beta-ecdysone. |
| PubMed:Acetylcholinesterase activity in an Aedes aegypti cell line. |
| PubMed:Arachnid oenocytes: ecdysone synthesis in the legs of harvestmen (Opilionidae). |
| PubMed:Pattern of peptide synthesis in Drosophila cell lines and their hybrids. |
| PubMed:Acetylcholinesterase induction by beta-ecdysone in Drosophila cell lines and their hybrids. |
| PubMed:Preparation of an ecdysone immunogen for radioimmunoassay work. |
| PubMed:Morphogenesis of mechanoreceptor and epidermal cells of crickets during the last instar, and its relation to molting-hormone level. |
| PubMed:Tubulin content and synthesis in differentiating Drosophila cells in culture. |
| PubMed:Inhibitory effect of beta-ecdysone on protein synthesis by blowfly fat body in vitro. |
| PubMed:[Dipetalonema dessetae--Aedes aegypti: study of the infected adipose tissue (author's transl)]. |
| PubMed:[Hormonal stimulation and in vitro cellular differentiation in the integument of the desert locust Schistocerca gregaria (author's transl)]. |
| PubMed:Influence of molt cycle and beta-ecdysone on protein synthesis in the chelicerate arthropod, Limulus polyphemus. |
| PubMed:Production of specific-protein secretion granules by fat body cells of the blowfly, Calliphora erythrocephala. Substitution of an ovarian key factor by beta-ecdysone. |
| PubMed:Protein synthesis in imaginal disks of Plodia interpunctella during development in vivo and in vitro. |
| PubMed:Alterations in ecdysone content during the post-embryonic development of Chironomus thummi: correlations with chromosomal puffing. |
| PubMed:Effects of two juvenile hormone analogs and beta-ecdysone on nymphal development, spermatogenesis, and embryogenesis in Dermacentor variabilis (Say) (Acari: Ixodidae). |
| PubMed:Intercellular communication in insect development is hormonally controlled. |
| PubMed:The mechanism of C-20 hydroxylation of alpha-ecdysone in the desert locust, Schistocerca gregaria. |
| PubMed:In vitro activation of neurosecretory brain cells in Mamestra brassicae by beta-ecdysone. |
| PubMed:Induction of acetylcholinesterase activity by beta-ecdysone in a Drosophila cell line. |
| PubMed:Radiation-induced inhibition of eclosion in the tobacco hornworm, Manduca sexta. |
| PubMed:The time during which beta-ecdysone is required for the differentiation in vitro and in situ of wing imaginal discs of Drosophila melanogaster. |
| PubMed:Active ion transport and beta-acdysone induced differentiation of Drosophila melanogaster imaginal discs cultured in vitro. |
| PubMed:The eversion and differentiation of Drosophila melanogaster leg and wing imaginal discs cultured in vitro with an optimal concentration of beta-ecdysone. |
| PubMed:beta-ecdysone levels in pharate pupae of the stable fly, Stomoxys calcitrans and interaction with the chitin inhibitor diflubenzuron. |
| PubMed:Juvenile hormone analogue counteracts growth stimulation and inhibition by ecdysones in clonal Drosophila cell line. |
| PubMed:Small circular DNA in Drosophila melanogaster. |
| PubMed:[Variations in the level of molting hormone during the second cycle of embryonic life in cockroaches]. |
| PubMed:[Comparison of the effects of alpha and beta ecdysone on a diploid clone of cultured Drosophila melanogaster cells in vitro: induction of proteins and morphological changes]. |
| PubMed:Selective activation of RNA polymerase I in fat body nuclei of Sarcophaga peregrina larvae by beta-ecdysone. |
| PubMed:The in vitro synthesis and secretion of alpha-ecdysone by the ring glands of the fly, Sarcophaga bullata. |
| PubMed:Hormonal control of growth and differentiation of insect tissues cultured in vitro. |
| PubMed:Separation and detection of alpha- and beta-ecdysone using thin-layer chromatography. |
| PubMed:Radioimmunoassay of arthropod moulting hormone:beta-ecdysone antibodies production and 125 I-iodinated tracer preparation. |
| PubMed:Uptake of beta-ecdysone by the fat body and membrane vesicles of fat body cells of Sarcophaga peregrina larvae. |
| PubMed:The initiation of adult development in Sarcophaga argyrostoma by beta-ecdysone. |
| PubMed:Biosynthesis of alpha- and beta-ecdysone by the crayfish Orconectes limosus in vivo and by its Y-organs in vitro. |
| PubMed:Effects of ecdysone and juvenile hormone on epidermal cell development in Hyalophora cecropia. |
| PubMed:Effects of beta-ecdysone and juvenile hormone on the Na+/K+-dependent ATPase in imaginal disks of Drosophila melanogaster. |
| PubMed:Biosynthesis of alpha-and beta-ecdysone in isolated abdomens of larvae of Musca domestica. |
| PubMed:Alpha- and beta-ecdysone levels in insect haemolymph: correlation with developmental events. |
| PubMed:Action of insect hormones at the cellular level. II. Differing sensitivity to beta-ecdysone of several lines and clones of Drosophila melanogaster cells. |
| PubMed:The ovary as a source of alpha-ecdysone in an adult mosquito. |
| PubMed:Effect of insect hormones on RNA polymerases of mass-isolated imaginal discs of Drosophila melanogaster cultured in vitro. |
| PubMed:The effect of beta-ecdysone on Gromphadorhina adult female fat body in the transcriptional and translational levels. |
| PubMed:beta-Ecdysone effects on the development of nucleopolyhedrosis in Heliothis spp. |
| PubMed:Uptake and binding of beta-ecdysone in imaginal discs of Drosophila melanogaster. |
| PubMed:RNA synthesis: a requirement for hormone-induced DNA amplification in Rhynchosciara americana. |
| PubMed:RNA synthesis in imaginal disks of Galleria mellonella: effects of alpha- and beta- ecdysone and fat body in vitro. |
| PubMed:[The effect of alpha- and beta-ecdysone on differentiation of imaginal disks of Drosophila melanogaster cultivated in vitro]. |
| PubMed:Influence of ecdysterone on the growth of cells and synthesis of macromolecules in established cell lines of Drosophila melanogaster. |
| PubMed:The effect of beta-ecdysone on protein synthesis in imaginal discs of Drosophila melanogaster cultured in vitro. |
| PubMed:The effect of beta-ecdysone on protein synthesis in imaginal discs of Drosophila melanogaster cultured in vitro. |
| PubMed:Isolation of beta-ecdysone (20-hydroxyecdysone) from the parasitic nematode Ascaris lumbricoides. |
| PubMed:Relative activities of alpha-ecdysone and beta-ecdysone for the differentiation in vitro of Drosophila melanogaster imaginal discs. |
| PubMed:[Action of beta-ecdysone on the development of larval and imaginal epidermal cell lines, from the abdomen of permanent larva of Ceratitis capitata Wied (Dipt. Trypetidae)]. |
| PubMed:Antibodies to the insect moulting hormone beta-ecdysone. |
| PubMed:Ecdysone-mediated stimulation of DOPA decarboxylase activity and its relationship to ovarian development in Aedes aegypti. |
| PubMed:Interactions between beta-ecdysone and fat body during wing disk development in vitro. |
| PubMed:The effects of eyestalk ablation and B-ecdysone on RNA synthesis in the androgenic glands of the protandric shrimp, Pandalus platyceros Brandt. |
| PubMed:The Secretion of alpha-Ecdysone by the Prothoracic Glands of Manduca sexta In Vitro. |
| PubMed:Galleria mellonella nerve cords in vitro: stage-specific survival and differential responsiveness to beta-ecdysone. |
| PubMed:Circadian control of the cellular response to beta-ecdysone in Drosophila lebanonensis. I. Experimental puff induction and its relation to puparium formation. |
| PubMed:Deposition of insect cuticle in vitro: differential responses to alpha- and beta-ecdysone. |
| PubMed:Effects and interactions of juvenile hormone and beta-ecdysone on Drosophila imaginal discs cultured in vitro. |
| PubMed:The apparent requirement of two hormones, alpha- and beta-ecdysone, for molting induction in insects. |
| PubMed:Effects of alpha-ecdysone, beta-ecdysone and inokosterone on the in vitro evagination of Drosophila leg discs and the subsequent differentiation of imaginal integumentary structures. |
| PubMed:The Activity of beta-Ecdysone in Four Gibberellin Bioassays. |
| PubMed:Increased RNase H (hybridase) activity in the integument of blowfly larvae during development and under the influence of beta-ecdysone. |
| PubMed:Binding proteins for an ecdysone metabolite in the crustacean hepatopancreas. |
| PubMed:Inhibitory effects of alpha-amanitin on RNA synthesis and induction of DOPA-decarboxylase by beta-ecdysone. |
| PubMed:Cellular Response to Ecdysterone in vitro. |
| PubMed:Conversion of alpha ecdysone to beta ecdysone by crustaceans and insects. |
| PubMed:[Structure of beta-ecdysone (1)]. |
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3D/inchi