EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

5-chlorosalicylic acid
benzoic acid, 5-chloro-2-hydroxy-

Supplier Sponsors

Name:5-chloro-2-hydroxybenzoic acid
CAS Number: 321-14-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-283-9
Nikkaji Web:J26.969G
Beilstein Number:2046665
XlogP3:3.10 (est)
Molecular Weight:172.56645000
Formula:C7 H5 Cl O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 171.50 °C. @ 760.00 mm Hg
Boiling Point: 320.50 °C. @ 760.00 mm Hg (est)
Flash Point: 298.00 °F. TCC ( 147.60 °C. ) (est)
logP (o/w): 3.090
Soluble in:
 water, 1.00E+04 mg/L @ 20 °C (exp)
 water, 522.2 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
BOC Sciences
For experimental / research use only.
5-Chlorosalicylic acid 98%
Santa Cruz Biotechnology
For experimental / research use only.
5-Chlorosalicylic Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
5-Chlorosalicylic Acid 98%
For experimental / research use only.
5-Chlorosalicylic Acid >98.0%(GC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo 250 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 792, 1955.

oral-rat LD50 250 mg/kg
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic ingredient for skin conditioning
Recommendation for 5-chlorosalicylic acid usage levels up to:
 not for fragrance use.
Recommendation for 5-chlorosalicylic acid flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):321-14-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9447
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5-chloro-2-hydroxybenzoic acid
RTECS:VO2080000 for cas# 321-14-2
 5-chloro-2-hydroxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):9447
Pubchem (sid):134975628
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.29.7500
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 benzoic acid, 5-chloro-2-hydroxy-
5-chloro salicylic acid
5-chloro-2-hydroxybenzoic acid
5-chlorosalicyclic acid
 chlorosalicylic acid
2-hydroxy-5-chlorobenzoic acid
 salicylic acid, 5-chloro-


PubMed:Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric.
PubMed:Effect of biological confinement on the photophysics and dynamics of a proton-transfer phototautomer: an exploration of excitation and emission wavelength-dependent photophysics of the protein-bound drug.
PubMed:Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6.
PubMed:On the photophysics of 3,5,6-Trichlorosalicylic acid: spectroscopic study combined with Hartree-Fock and Density Functional Theory calculations.
PubMed:Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori.
PubMed:Deciphering the photophysics of 5-chlorosalicylic acid: evidence for excited-state intramolecular proton transfer.
PubMed:In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
PubMed:Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes.
PubMed:Two angular dioxygenases contribute to the metabolic versatility of dibenzofuran-degrading Rhodococcus sp. strain HA01.
PubMed:Guest-controlling effects on ER behaviors of beta-cyclodextrin polymer.
PubMed:Effect of ion-exchange fiber structure on the binding and release of model salicylates.
PubMed:New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1.
PubMed:Degradation of chlorinated dibenzofurans and dibenzo-p-dioxins by two types of bacteria having angular dioxygenases with different features.
PubMed:Synthesis and biological activity of new diarylalkenes.
PubMed:Biodegradation pathway of 2-chlorodibenzo-p-dioxin and 2-chlorodibenzofuran in the biphenyl-utilising strain JB1.
PubMed:Defense Responses in Infected and Elicited Cucumber (Cucumis sativus L.) Hypocotyl Segments Exhibiting Acquired Resistance.
PubMed:Pretreatment of Parsley (Petroselinum crispum L.) Suspension Cultures with Methyl Jasmonate Enhances Elicitation of Activated Oxygen Species.
PubMed:Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites.
PubMed:Conditioning of Parsley (Petroselinum crispum L.) Suspension Cells Increases Elicitor-Induced Incorporation of Cell Wall Phenolics.
PubMed:Mutagenic activity of 2-chloro-4-nitroaniline and 5-chlorosalicylic acid in Salmonella typhimurium: two possible metabolites of niclosamide.
PubMed:Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action.
PubMed:Microbial metabolism of chlorosalicylates: effect of prolonged subcultivation on constructed strains.
PubMed:Microbial metabolism of chlorosalicylates: accelerated evolution by natural genetic exchange.
PubMed:Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
PubMed:Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation.
PubMed:Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.
PubMed:[Chronic toxicity of 4-chloroanilide of 5-chlorosalicylic acid (Arylide)].
PubMed:Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
PubMed:Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats.
PubMed:Absorption, distribution, and metabolic fate of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one in rats, dogs, and humans.
PubMed:[Bactericidal effect of streptomycin on acid-fast bacilli in the presence of 4-chloroanilid of 5-chlorosalicylic acid].
PubMed:[Some pharmacological properties of 4-chloroanilide of 5-chlorosalicylic acid].
PubMed:[Binding of 4-chloroanilide of 5-chlorosalicylic acid by blood serum proteins and other protein substances. I. Qualitative methods for determination of the binding of arylid by protein substances].
PubMed:Structural studies on complexes. IV. Crystal structure of a 1:1 5-chlorosalicylic acid and theophylline complex.
PubMed:[Toxicity of 4-chloroanilid of 5-chlorosalicylic acid (arylid) for various species of laboratory animals].
PubMed:[Effect of 5-chlorosalicylic acid, 4-chloroanilide on tubercle bacilli].
PubMed:[Effect of 4-chloroanilid of 5-chlorosalicylic acid on the viability of tubercle bacilli in vitro].
PubMed:[Effect of 4-chloroanilid of 5-chlorosalicylic acid on experimental tuberculosis in guinea pigs].
PubMed:[Effect of the 4-chloroanilide of 5-chlorosalicylic acid on the respiration of tubercle bacilli].
PubMed:[Effect of 4-chloroanilide of 5-chlorosalicylic acid in experimental tuberculosis of white mice].
PubMed:[Treatment of epidermophytosis with the 2'-chloroanilide of 5-chlorosalicylic acid].
major metabolite of meseclazone.
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy