EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

chloroxylenol
2-chloro-m-xylenol

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Name:4-chloro-3,5-dimethylphenol
CAS Number: 88-04-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-793-8
FDA UNII: 0F32U78V2Q
Nikkaji Web:J4.285D
Beilstein Number:1862539
MDL:MFCD00002324
XlogP3:2.00 (est)
Molecular Weight:156.61093000
Formula:C8 H9 Cl O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):88-04-0 ; CHLOROXYLENOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:white crystalline solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 115.00 °C. @ 760.00 mm Hg
Boiling Point: 246.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.011000 mmHg @ 20.00 °C. (est)
Flash Point: 223.00 °F. TCC ( 105.90 °C. ) (est)
logP (o/w): 3.270
Soluble in:
 water, 250 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
deodorants
preservatives
 
Suppliers:
American International Chemical, LLC.
Chloroxylenol
BOC Sciences
For experimental / research use only.
4-Chloro-3,5-dimethylphenol >98 %
Odor: characteristic
Use: 4-Chloro-3,5-dimethylphenol is a chemical compound which has antimicrobial effect due to disruption of cell membrane potentials. lt is an antiseptic and germicide. It is mainly used to control bacteria, algae, fungi and virus and is used in hospitals 4-Chloro-3,5-dimethylphenol is mainly used to control bacteria, algae, fungi and virus and is used in hospitals and
Kingyoung Bio Technical
Chloroxylenol
Santa Cruz Biotechnology
For experimental / research use only.
4-Chloro-3,5-dimethylphenol
Shiva Chemicals and Pharmaceuticals
PCMX
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Chloro-3,5-dimethylphenol 99%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 115000 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 41, Pg. 595, 1952.

oral-mouse LD50 1000 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: OTHER CHANGES
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

oral-rat LD50 3830 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES
Journal of the American College of Toxicology. Vol. 4(5), Pg. 147, 1985.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for chloroxylenol usage levels up to:
 not for fragrance use.
 
Recommendation for chloroxylenol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):88-04-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2723
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
4-chloro-3,5-dimethylphenol
Chemidplus:0000088040
RTECS:ZE6850000 for cas# 88-04-0
 
References:
 4-chloro-3,5-dimethylphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:88-04-0
Pubchem (cid):2723
Pubchem (sid):134972013
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14715
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2908.10.5000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
dettol (reckitt and colman, uk)
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4-chloro-3,5-dimethyl phenol
4-chloro-3,5-dimethylphenol
4-chloro-3,5-xylenol
2-chloro-5-hydroxy-1,3-dimethylbenzene
2-chloro-5-hydroxy-m-xylene
p-chloro-m-xlenol
2-chloro-m-xylenol
p-chloro-m-xylenol
para-chloro-meta-xlenol
para-chloro-meta-xylenol
3,5-dimethyl-4-chlorophenol
 nipacide PX
 phenol, 4-chloro-3,5-dimethyl-
 

Articles:

PubMed:Complex mechanism of relaxation in solid chloroxylenol (antibacterial/antifungal agent) studied by ¹H NMR spectroscopy and density functional theory calculations.
PubMed:Effectiveness of various hospital-based solutions against community- acquired methicillin-resistant Staphylococcus aureus.
PubMed:Oregano essential oil as an antimicrobial additive to detergent for hand washing and food contact surface cleaning.
PubMed:North American Contact Dermatitis Group patch test results for 2007-2008.
PubMed:Hand hygiene regimens for the reduction of risk in food service environments.
PubMed:Skin preparation for preventing infection following caesarean section.
PubMed:Dettol poisoning and the need for airway intervention.
PubMed:Conformations and intermolecular interactions pattern in solid chloroxylenol and triclosan (API of anti-infective agents and drugs). A (35) Cl NQR, (1) H-(14)  N NQDR, X-ray and DFT/QTAIM study.
PubMed:Bioassay-directed identification of novel antiandrogenic compounds in bile of fish exposed to wastewater effluents.
PubMed:Contact depigmentation following irritant contact dermatitis to chloroxylenol (Dettol).
PubMed:Comparative in vitro efficacy of antimicrobial shampoos: a pilot study.
PubMed:Determination of phenolic disinfectants in consumer products by capillary electrophoresis with amperometric detection.
PubMed:Evaluation of the tissue toxicity of antiseptics by the hen's egg test on the chorioallantoic membrane (HETCAM).
PubMed:Screening level ecological risk assessment for phenols in surface water of the Taihu Lake.
PubMed:The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus.
PubMed:Hand dermatitis: a focus on allergic contact dermatitis to biocides.
PubMed:Occupation-related contact dermatitis in North American health care workers referred for patch testing: cross-sectional data, 1998 to 2004.
PubMed:Mineralization of the biocide chloroxylenol by electrochemical advanced oxidation processes.
PubMed:A review of anti-septic agents for pre-operative skin preparation.
PubMed:In-vitro activity and in-vivo efficacy of catheters impregnated with chloroxylenol and thymol against uropathogens.
PubMed:Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach.
PubMed:Patch testing experience with 1000 patients.
PubMed:Contact sensitivity to preservatives in the UK, 2004-2005: results of multicentre study.
PubMed:Chloroxylenol.
PubMed:Allergic contact dermatitis to chloroxylenol.
PubMed:The effects of biocides (antiseptics and disinfectants) on the endospores of Rhinosporidium seeberi.
PubMed:Antifungal activity of antimicrobial-impregnated devices.
PubMed:Contact inactivation of orthopoxviruses by household disinfectants.
PubMed:Contact sensitivity to preservatives in Turkey.
PubMed:Efficacy of surgical preparation solutions in foot and ankle surgery.
PubMed:[Simultaneous determination of chloroxylenol, trilocarban and triclosan in cosmetics or household products by reversed-phase high performance liquid chromatography].
PubMed:Identification of estrogenic compounds in fish bile using bioassay-directed fractionation.
PubMed:Use of the 'ex vivo' test to study long-term bacterial survival on human skin and their sensitivity to antisepsis.
PubMed:[Efficacy of biocides against hospital isolates of Staphylococcus sensitive and resistant to methicillin, in the province of Buenos Aires, Argentina].
PubMed:Comparison of two in vivo and two ex vivo tests to assess the antibacterial activity of several antiseptics.
PubMed:Comparative analysis of antibiotic and antimicrobial biocide susceptibility data in clinical isolates of methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa between 1989 and 2000.
PubMed:Stridor after ingestion of dettol and domestos.
PubMed:Comparison of chloroxylenol 0.5% plus salicylic acid 2% cream and benzoyl peroxide 5% gel in the treatment of acne vulgaris: a randomized double-blind study.
PubMed:An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity.
PubMed:Evaluation of diazotized 4-amino-3,5-dinitrobenzoic acid (ADBA) as a new derivatizing reagent.
PubMed:Allergenicity evaluation of p-chloro-m-cresol and p-chloro-m-xylenol by non-radioactive murine local lymph-node assay and multiple-dose guinea pig maximization test.
PubMed:Quality control of decontaminating agents.
PubMed:Salvage therapy of open, infected surgical wounds: a retrospective review using Techni-Care.
PubMed:The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance.
PubMed:Contamination of toothbrush at different time intervals and effectiveness of various disinfecting solutions in reducing the contamination of toothbrush.
PubMed:Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America.
PubMed:Chloroxylenol- and triclosan-tolerant bacteria from industrial sources.
PubMed:Toxicological screening for drugs of abuse in samples adulterated with household chemicals.
PubMed:Comparative susceptibility of resident and transient hand bacteria to para-chloro-meta-xylenol and triclosan.
PubMed:Antimicrobial efficacy of chloroxylenol and chlorhexidine in the treatment of infected root canals.
PubMed:Assessment of resistance towards biocides following the attachment of micro-organisms to, and growth on, surfaces.
PubMed:Post-inflammatory depigmentation following allergic contact dermatitis to chloroxylenol.
PubMed:Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na(+) channel.
PubMed:Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate.
PubMed:Antimicrobial susceptibility of 19 Australian corneal isolates of Acanthamoeba.
PubMed:A method of assessing the efficacy of hand sanitizers: use of real soil encountered in the food service industry.
PubMed:Chloroxylenol and zinc oxide containing cream (Nels cream) vs. 5% benzoyl peroxide cream in the treatment of acne vulgaris. A double-blind, randomized, controlled trial.
PubMed:Disinfectants/antiseptics in the management of guinea worm ulcers in the rural areas.
PubMed:Antimicrobial effect of camphorated chloroxylenol (ED 84) in the treatment of infected root canals.
PubMed:In vivo efficacy of antimicrobial-coated fabric from prosthetic heart valve sewing rings.
PubMed:Anti-infective efficacy of antiseptic-coated intramedullary nails.
PubMed:Serratia marcescens outbreak associated with extrinsic contamination of 1% chloroxylenol soap.
PubMed:Changes in the biocide susceptibility of Staphylococcus epidermidis and Escherichia coli cells associated with rapid attachment to plastic surfaces.
PubMed:Antimicrobial activity of antiseptic-coated orthopaedic devices.
PubMed:Chloroxylenol causing hand dermatitis in a plumber.
PubMed:The action of three antiseptics/disinfectants against enveloped and non-enveloped viruses.
PubMed:HPLC-fluorescence determination of chlorocresol and chloroxylenol in pharmaceuticals.
PubMed:Serratia marcescens outbreak associated with extrinsic contamination of 1% chlorxylenol soap.
PubMed:Evaluation, modelling and optimization of the cleaning process of contaminated plastic food refillables.
PubMed:Delayed upper airway obstruction. A life-threatening complication of Dettol poisoning.
PubMed:Chlorhexidine gluconate versus chloroxylenol for preoperative skin preparation in dogs.
PubMed:Pulmonary aspiration following Dettol poisoning: the scope for prevention.
PubMed:Collection of urine from washed-up potties.
PubMed:Association of bacterial vaginosis with a history of second trimester miscarriage.
PubMed:The risk of aspiration in Dettol poisoning: a retrospective cohort study.
PubMed:Chemical gastro-oesophagitis, upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning.
PubMed:Comparative ability of various prescription and over-the-counter topical antifungal drug products to inhibit the growth of C. albicans.
PubMed:Reaction of inflamed periapical tissue to intracanal medicaments and root canal sealers.
PubMed:Poisoning due to Savlon (cetrimide) liquid.
PubMed:Staphylococcus aureus colonization of teat skin as affected by postmilking teat treatment when exposed to cold and windy conditions.
PubMed:Comparative evaluation of five surgical hand scrub preparations.
PubMed:Is chloroxylenol nephrotoxic like phenol? A study of patients with DETTOL poisoning.
PubMed:Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites.
PubMed:The spectrum of poisonings in Hong Kong: an overview.
PubMed:Serious complications associated with Dettol poisoning.
PubMed:Synthesis and stability of isotopically labeled p-chloro-m-xylenol (PCMX).
PubMed:Preoperative skin preparation and intraoperative pelvic irrigation: impact on post-cesarean endometritis and wound infection.
PubMed:Aseptic technique in microgravity.
PubMed:Evaluation of the repeatability and reproducibility of European suspension test methods for antimicrobial activity of disinfectants and antiseptics.
PubMed:Pharmacokinetic and metabolic disposition of p-chloro-m-xylenol (PCMX) in dogs.
PubMed:Computerized image analysis of full-hand touch plates: a method for quantification of surface bacteria on hands and the effect of antimicrobial agents.
PubMed:The cytotoxicity of p-chloro-m-xylenol in primary culture of rat hepatocytes.
PubMed:Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action.
PubMed:[Experimental study of topical uses of para-chloro-methyl-xylenol in burns: therapeutic effect against Staphylococcus aureus].
PubMed:Androgenetic alopecia--is contact dermatitis an accelerating factor?
PubMed:Contact sensitivity to topical antimicrobials. (II). Sensitizing potentials of some topical antimicrobials.
PubMed:Allergic contact dermatitis from para-chloro-meta-xylenol in Lurosep soap.
PubMed:Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes.
PubMed:[Combined long-term toxicity and carcinogenicity test of p-chloro-m-xylenol (PCMX) applied to female mouse skin].
PubMed:Factors influencing the survival and multiplication of bacteriophages in calves and in their environment.
PubMed:[Bactericidal activity of disinfectants against certain bacterial strains. Klebsiella pneumonia].
PubMed:Report on chloroxylenol-containing antiseptic: reference correction.
PubMed:[Modification of the sensitivity of Pseudomonas aeruginosa ATCC 15442 to chloroxylenol in the presence of protamine].
PubMed:Concerning the report on chloroxylenol-containing antiseptic: queries and response.
PubMed:Electrocardiography electrode and hand dermatitis from parachlorometaxylenol.
PubMed:An approach for selection of health care personnel handwashing agents.
PubMed:The efficacy of several new handwashing agents for removing non-transient bacterial flora from hands.
PubMed:The antiseptic efficacy of chlorxylenol-containing vs. chlorhexidine gluconate-containing surgical scrub preparations.
PubMed:Contact sensitivity to parachlorometaxylenol (PCMX).
PubMed:The bactericidal activity of aqueous disinfectants applied on living tissues.
PubMed:Para-chloro-meta-xylenol (PCMX): a new, potential topical antimicrobial agent.
PubMed:Dettol (chloroxylenol and terpineol) poisoning in a pregnant patient. A case report.
PubMed:Chloroxylenol and EDTA kill P. aeruginosa.
PubMed:P-chloro-m-xylenol in cutting fluids: two cases of allergic contact dermatitis in machinists.
PubMed:Iatrogenic dermatitis.
PubMed:The protective potentials of 4-chloro-3, 5-xylenol (Dettol) against Mansonian schistosomiasis.
PubMed:Disinfection of the skin of the abdomen.
PubMed:Simultaneous programmed temperature GLC assay of phenol, chloroxylenol, and lidocaine hydrochloride in topical antiseptic cream.
PubMed:Severe Dettol (chloroxylenol and terpineol) poisoning.
PubMed:The antibacterial activity of a new chloroxylenol preparation containing ethylenediamine tetraacetic acid.
PubMed:Comparison of four selective agars for the isolation of pseudomonads.
PubMed:Suicidal intoxication with Dettol (chloroxylenol) (a case report).
PubMed:The antibacterial activity of chloroxylenol in combination with ethylenediaminetetra-acetic acid.
PubMed:Para-chloro-meta-xylenol allergic contact dermatitis in seven individuals.
PubMed:Chlorocresol sensitivity.
PubMed:A membrane filter technique for testing disinfectants.
PubMed:Chlorhexidine resistance in Proteus mirabilis.
PubMed:The interaction of benzoic acid and chloroxylenol with cetomacrogol.
PubMed:BACTERICIDAL ACTIVITY OF CHLOROXYLENOL IN AQUEOUS SOLUTIONS OF CETOMACROGOL.
PubMed:A chronicle of tinea pedis and chloroxylenol for control of tinea pedis.
PubMed:Non-ionic surface-active agents. I. The solubility of chloroxylenol in aqueous solutions of polyethylene glycol 1000 monocetyl ether.
PubMed:A study of the pharmacopoeial method for the preparation of solution of chloroxylenol.
PubMed:The bactericidal activity of phenols in aqueous solutions of soap. III. The bactericidal activity of chloroxylenol in aqueous solutions of potassium laurate.
PubMed:Blood concentration of P-chloro-xylenol in man following parenteral, percutaneous and rectal application.
 
Notes:
topical antiseptic.
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