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Category:hair dyeing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | almost black needles (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 137.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 385.40 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 5.600000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 368.00 °F. TCC ( 186.90 °C. ) (est)
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| logP (o/w): | 0.530 |
| Soluble in: |
| | water, 2.592e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 214 mg/kg
Genetica Polonica. Vol. 26, Pg. 109, 1985.
intraperitoneal-rat LD50 348 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.
oral-rat LD50 2100 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Journal of the Society of Cosmetic Chemists. Vol. 23, Pg. 259, 1972.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | hair dyeing agents |
| Recommendation for 2-nitro-p-phenylenediamine usage levels up to: | | | not for fragrance use.
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| Recommendation for 2-nitro-p-phenylenediamine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C19385 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2921.51.5000 |
| ChemSpider: | View |
Formulations/Preparations:
•...avail in us as commercial grade with following typical specifications: assay, 97% min; melting range, 135-138 deg c; loss on drying, 1.0% max; iron content, 100 mgkg max; residue on ignition, 0.3%.
•2-nitro-p-phenylenediamine is available commercially in purities ranging from 95 to 100%, with 4-amino-3-nitroacetanilide as a possible impurity.
•2-nitro-p-phenylenediamine has the following specifications: ash, 0.1% (max); iron, 40 ppm (max); lead, 5 ppm (max); and arsenic, 2ppm(max).
•it has been used in hair dyes dark-brown (@ levels of 0.1%), medium-brown (0.15%), medium-red (2.5%) & ash-blond (0.065%) dye formulations. it can also be used in bleach-toner formulations for golden-blond (0.008%) & red-blond (0.02%) shades.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,4- | benzenediamine, 2-nitro- | | | c.i. 76070 | | | C.I. oxidation base 22 | | | ci 76070 | | 1,4- | diamino-2-nitrobenzene | | | du rafur brown | | | durafur brown | | | durafur brown 2R | | | fouramine 2R | | | fourrine 36 | | | fourrine brown 2R | | | glycidyl-4-nitrophenyl ether | | 2- | nitro-1,4-benzenediamine | | 2- | nitro-1,4-diaminobenzene | | 2- | nitro-1,4-phenylene diamine | | 2- | nitro-1,4-phenylenediamine | | 2- | nitro-4-aminoaniline | | 2- | nitro-4-phenylenediamine | | 2- | nitro-p-phenylendiamine | | 2- | nitro-para-phenylendiamine | | 2- | nitro-para-phenylene diamine | | 2- | nitro-para-phenylenediamine | | 2- | nitrobenzene-1,4-diamine | | 2- | nitrol-p-phenylenediamine | | 2- | nitrol-para-phenylenediamine | | p- | phenylenediamine, 2-nitro- | | | ursol brown RR | | | zoba brown RR |
Articles:
| PubMed:Single strand dna breaks in human lymphocytes exposed to para-phenylenediamine and its derivatives. |
| PubMed:Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study. |
| PubMed:Percutaneous penetration and metabolism of 2-nitro-p-phenylenediamine in human and fuzzy rat skin. |
| PubMed:Comparison of the mutagenic specificity induced by four nitro-group-containing aromatic amines in Salmonella typhimurium his genes. |
| PubMed:Mutagenicity and antimutagenicity studies of tannic acid and its related compounds. |
| PubMed:Base-pair mutation caused by four nitro-group containing aromatic amines in Salmonella typhimurium TA100, TA104, TA4001 and TA4006. |
| PubMed:Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay. |
| PubMed:Effects of the nitro-group on the mutagenicity and toxicity of some benzamines. |
| PubMed:Mutagenicity and toxicity studies of p-phenylenediamine and its derivatives. |
| PubMed:Mutagenicity of selected aniline derivatives to Salmonella following plant activation and mammalian hepatic activation. |
| PubMed:Percutaneous absorption of hair dyes: correlation with partition coefficients. |
| PubMed:Assessment of sister chromatid exchange in spermatogonia and intestinal epithelium in Chinese hamsters. |
| PubMed:Percutaneous absorption of 2-nitro-p-phenylenediamine. |
| PubMed:Chemically-induced sister-chromatid exchange in vivo in bone marrow of Chinese hamsters. An evaluation of 24 compounds. |
| PubMed:Distribution, excretion, and metabolism of nitro-p-phenylenediamine in rats. |
| PubMed:Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse. |
| PubMed:In vivo skin penetration studies of 2,4-toluenediamine, 2,4-diaminoanisole, 2-nitro-p-phenylenediamine, p-dioxane and N-nitrosodiethanolamine in cosmetics. |
| PubMed:Induction of mitotic recombination by certain hair-dye chemicals in Saccharomyces cerevisiae. |
| PubMed:Carcinogenicity of the hair-dye component 2-nitro-p-phenylenediamine: induction of eosinophilic hepatocellular neoplasms in female B6C3F1 mice. |
| PubMed:Dominant lethal assay of some hair-dye components in random-bred male rats. |
| PubMed:Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. |
| PubMed:The mutagenic assay of some hair dye components, using the thymidine kinase locus of L5178Y mouse lymphoma cells. |
| PubMed:Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells. |
| PubMed:Dominant lethal mutagenicity study on hair dyes. |
| PubMed:Hair dyes are mutagenic: identification of a variety of mutagenic ingredients. |
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3D/inchi