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Category:herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale brown to brownish-yellow solid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 50.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 238.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.008000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 306.00 °F. TCC ( 152.22 °C. )
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| logP (o/w): | 0.093 (est) |
| Soluble in: |
| | water, 7.958e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-bird - wild LD50 75 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
oral-guinea pig LD50 130 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BLOOD: OTHER CHANGES
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
oral-mouse LD50 105 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: OTHER CHANGES
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
oral-rabbit LD50 150 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BLOOD: OTHER CHANGES
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
intraperitoneal-rat LD50 52435 ug/kg
Journal of Pharmacy and Pharmacology. Vol. 26, Pg. 597, 1974.
oral-rat LD50 105 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: OTHER CHANGES
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-mouse LCLo 150 mg/m3/2H
BLOOD: HEMORRHAGE
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 13, 1965.
inhalation-rat LCLo 150 mg/m3/2H
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
BLOOD: HEMORRHAGE
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 13, 1965.
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Safety in Use Information:
| Category: | | herbicides / pesticides |
| Recommendation for 2-butyne-1,4-diol usage levels up to: | | | not for fragrance use.
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| Recommendation for 2-butyne-1,4-diol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | but-2-yne-1,4-diol | | 1,4- | butynediol | | 1,4- | butynediol [UN2716] [Poison] | | 1,4- | dihydroxy-2-butyne | | 1,4- | dimethoxyacetylene |
Articles:
| PubMed:Kinetic and DFT studies on the mechanism of C-S bond formation by alkyne addition to the [Mo3S4(H2O)9]4+ cluster. |
| PubMed:Selective semihydrogenation of alkynes on shape-controlled palladium nanocrystals. |
| PubMed:[Setting limit values for chemical substances in the workplace: DNEL(INH) setting according to REACH principles following the example of 2-butyne-1,4-diol]. |
| PubMed:Preparation of 2-iodo allylic alcohols from 2-butyn-1,4-diol. |
| PubMed:Calculation of electric dipole intensity parameter to explore some interaction between hard metal ions Pr(III) and Nd(III) with pi-electron density of butene-1,4 and butyne-1,4-diols in non-aqueous solutions: an absorption spectral study. |
| PubMed:Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. |
| PubMed:The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists. |
| PubMed:A 13C solid-state NMR investigation of the alkynyl carbon chemical shift tensors for 2-butyne-1,4-diol. |
| PubMed:Allergic contact dermatitis from 2-butin-1,4-diol. |
| PubMed:Investigation of Electrosorption of Organic Molecules onto Gold and Nickel Electrodes Using an Electrochemical Quartz Crystal Microbalance. |
| PubMed:Developmental toxicity of 2-butin-1,4-diol following oral administration to the rat. |
| PubMed:Subacute oral toxicity of 2-butyne-1,4-diol in rats. |
| PubMed:Acute toxicity of 2-butyne-1,4-diol in laboratory animals. |
| PubMed:A chemical study of 2-butyne-1,4-diol. |
| PubMed:Contact dermatitis to Butin-2-diol 1,4. |
| PubMed:Redox activation of galactose oxidase: thin-layer electrochemical study. |
| PubMed:Irreversible inactivation of the flavoenzyme alcohol, oxidase with acetylenic alcohols. |
| PubMed:But-2-yne-1,4 diol, primary gloss improver and contact sensitizer in a nickel plating bath. |
| PubMed:Hypothermic and toxic actions of 2-butyne-1, 4-diol and other related diols in the rat. |
| PubMed:Formation of dibutylphthalate from 2-butyne-1,4-diol by a soil bacterium. |
| PubMed:SEPARATION OF 2-BUTYNE-1,4-DIOL, ITS MONOESTERS AND DIESTERS: A COMPARISON OF GLASS-PAPER CHROMATOGRAPHY AND THIN-LAYER CHROMATOGRAPHY. |
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3D/inchi