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2-benzoyl pyridine
phenyl-2-pyridinylmethanone

Supplier Sponsors

Name:phenyl(pyridin-2-yl)methanone
CAS Number: 91-02-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-034-3
FDA UNII:IZ1TTI0X5O
Nikkaji Web:J41.577D
Beilstein Number:0120283
MDL:MFCD00006300
XlogP3:1.90 (est)
Molecular Weight:183.20993000
Formula:C12 H9 N O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 42.00 to 44.00 °C. @ 760.00 mm Hg
Boiling Point: 317.00 °C. @ 760.00 mm Hg
Boiling Point: 317.00 to 318.00 °C. @ 760.00 mm Hg (est)
Flash Point: 302.00 °F. TCC ( 150.00 °C. )
logP (o/w): 1.880
Soluble in:
 alcohol
 water, 1317 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Flavor Type: bitter
bitter musty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Doxylamine Hydrogen Succinate Impurity D > 95%
Odor: characteristic
Use: An Impurity of Doxylamine Hydrogen Succinate.
EMD Millipore
For experimental / research use only.
2-Benzoylpyridine
Santa Cruz Biotechnology
For experimental / research use only.
2-Benzoylpyridine
Sigma-Aldrich: Aldrich
For experimental / research use only.
2-Benzoylpyridine ≥99%
TCI AMERICA
For experimental / research use only.
2-Benzoylpyridine >99.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 475 mg/kg
Journal of Medicinal Chemistry. Vol. 14, Pg. 551, 1971.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for 2-benzoyl pyridine usage levels up to:
 not for fragrance use.
 
Recommendation for 2-benzoyl pyridine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA Substance Registry Services (TSCA):91-02-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7038
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
phenyl(pyridin-2-yl)methanone
Chemidplus:0000091021
RTECS:OB6400000 for cas# 91-02-1
 
References:
 phenyl(pyridin-2-yl)methanone
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:91-02-1
Pubchem (cid):7038
Pubchem (sid):134971285
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.39.9100
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-benzoylpyridine
 ketone, phenyl 2-pyridyl
 methanone, phenyl-2-pyridinyl-
 phenyl (pyridin-2-yl) methanone
 phenyl 2-pyridyl ketone
 phenyl pyridin-2-yl ketone
 phenyl-2-pyridinylmethanone
 phenyl-a-pyridylketone
 phenyl-pyridin-2-yl-methanone
 phenyl(pyridin-2-yl)methanone
 pyridine, 2-benzoyl-
2-pyridyl phenyl ketone
 

Articles:

US Patents:3,952,024 - Furfurylthioacetone
PubMed:Structural studies and antileishmanial activity of 2-acetylpyridine and 2-benzoylpyridine nitroimidazole-derived hydrazones
US Patents:Certain 2,5-dimethyl-3-thiopyrazines
PubMed:2-Benzoylpyridine Ligand Complexation with Gold Critical for Propargyl Ester-Based Protein Labeling
PubMed:Rhodium (II) complex with 2-benzoylpyridine, a novel potential chemotherapeutic drug, induces cell cycle arrest and apoptosis in HepG2 cells
PubMed:[Ag(L)NO(3)] Complexes with 2-Benzoylpyridine-Derived Hydrazones: Cytotoxic Activity and Interaction with Biomolecules
PubMed:Interesting copper(ii)-assisted transformations of 2-acetylpyridine and 2-benzoylpyridine
PubMed:2-Acetylpyridine- and 2-benzoylpyridine-derived hydrazones and their gallium(III) complexes are highly cytotoxic to glioma cells
PubMed:Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis
PubMed:2-Benzoylpyridine thiosemicarbazone as a novel reagent for the single pot synthesis of dinuclear Cu(I)-Cu(II) complexes: formation of stable copper(II)-iodide bonds
PubMed:Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity
PubMed:Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: cytotoxicity against human leukemia cell lines
PubMed:Bismuth(III) complexes with 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones: Antimicrobial and cytotoxic activities and effects on the clonogenic survival of human solid tumor cells
PubMed:Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance
PubMed:Less toxic zinc(ii), diorganotin(iv), gallium(iii) and cadmium(ii) complexes derived from 2-benzoylpyridine N,N-dimethylthiosemicarbazone: synthesis, crystal structures, cytotoxicity and investigations of
PubMed:Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinas
PubMed:Synthesis, anti-bacterial evaluation, DFT study and molecular docking as a potential 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2 inhibitors of a novel Schiff bases
PubMed:Correction to [Ag(L)NO(3)] Complexes with 2-Benzoylpyridine-Derived Hydrazones: Cytotoxic Activity and Interaction with Biomolecules
PubMed:Synthesis, crystal structures, and biological evaluation of Cu(II) and Zn(II) complexes of 2-benzoylpyridine Schiff bases derived from S-methyl- and S-phenyldithiocarbazates
PubMed:Oxidovanadium(IV) and dioxidovanadium(V) complexes of hydrazones of 2-benzoylpyridine and their catalytic applications
PubMed:Syntheses and Structures of the Complexes cis-[M(C(6)F(5))(2)(N&arcraise;X)] (M = Pd, Pt; N&arcraise;X = 2-Iodoaniline, 2-Benzoylpyridine) Containing N&arcraise;X Acting as a Didentate Chelating Ligand and
PubMed:Unravelling the reaction mechanism for the fast photocyclisation of 2-benzoylpyridine in aqueous solvent by time-resolved spectroscopy and density functional theory calculations
PubMed:Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation
PubMed:Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy
PubMed:Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity
PubMed:Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligan
PubMed:The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonuc
PubMed:Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy
PubMed:2-Benzoylpyridine-N(4)-tolyl thiosemicarbazones and their palladium(II) complexes: cytotoxicity against leukemia cells
PubMed:Carbon-Phosphorus Coupling from C^N Cyclometalated Au(III) Complexes
PubMed:Cytotoxicity and structure-activity relationships of four alpha-N-heterocyclic thiosemicarbazone derivatives crystal structure of 2-acetylpyrazine thiosemicarbazone
PubMed:Flame AAS and UV-VIS determination of cobalt, nickel and palladium using the synergetic effect of 2-benzoylpyridine-2-pyridylhydrazone and thiocyanate ions
PubMed:Palladium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones: spectral characterization, structural studies and cytotoxic activity
PubMed:Ruthenium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones with cytotoxic activity against human tumor cell lines
PubMed:Excited electronic states and Raman spectra of 2-benzoylpyridine
PubMed:Ruthenium(II) complexes containing 2-pyridineformamide- and 2-benzoylpyridine-derived thiosemicarbazones and PPh3: NMR and electrochemical studies of cis-trans-isomerization
PubMed:Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes
PubMed:Rhodium-Catalyzed Pyridine N-Oxide Assisted Suzuki-Miyaura Coupling Reaction via C(O)-C Bond Activation
PubMed:Multifunctional Reactive MALDI Matrix Enabling High-Lateral Resolution Dual Polarity MS Imaging and Lipid CÍC Position-Resolved MS(2) Imaging
PubMed:2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity
PubMed:Towards blue emitting monocyclometalated gold(iii) complexes - synthesis, characterization and photophysical investigations
PubMed:Synthesis, structure and reactivity of rare-earth metallacarborane alkyls [?(1):?(5)-O(CH2)2C2B9H9]Ln(ĺ:?(1)-CH2C6H4-o-NMe2)(THF)2
PubMed:Multiple Cycloaddition Reactions of Ketones with a ?-Diketiminate Al Compound
PubMed:Cyclometalated Au(III) Complexes for Cysteine Arylation in Zinc Finger Protein Domains: towards Controlled Reductive Elimination
PubMed:Spectral characterization and crystal structure of 2-benzoylpyridine nicotinoyl hydrazone
PubMed:Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor ag
PubMed:Benchmarking Water Oxidation Catalysts Based on Iridium Complexes: Clues and Doubts on the Nature of Active Species
PubMed:Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: synthesis, characterization, X-ray crystal structures and antitumor comparison
PubMed:Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous admini
PubMed:Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes
PubMed:Concentration-dependent surface-enhanced Raman scattering of 2-benzoylpyridine adsorbed on colloidal silver particles
PubMed:Two azido-bridged homospin Fe(ii)/Co(ii) coordination polymers featuring single-chain magnet behavior
PubMed:Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers
PubMed:The medicinal chemistry of novel iron chelators for the treatment of cancer
PubMed:LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT
PubMed:Design and characterization of Cu(II) complexes from 2-benzoylpyridine benzhydrazone: crystallographic evidence for coordination versatility
PubMed:Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status
PubMed:Synthesis and spectral characterization of mono- and binuclear copper(II) complexes derived from 2-benzoylpyridine-N?-methyl-3-thiosemicarbazone: crystal structure of a novel sulfur bridged copper(II) box-
PubMed:Gold(I) complexes with thiosemicarbazones: cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity
PubMed:Reaction of ?-diketiminate tin(II) dimethylamide LSnNMe? [L = HC(CMeNAr)?; Ar = 2,6-iPr?C?H?] with ketones and alkynes
PubMed:Four Cu(ii) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity
PubMed:Application of the deford and hume method modified for quasi-reversible and irreversible processes to the chelates of Bi(III) with azomethine derivatives of 2-benzoylpyridine
PubMed:Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents
PubMed:Beckmann rearrangement of the oximes of phenyl 2-pyridyl ketone (2-benzoylpyridine)
PubMed:Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds
PubMed:Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism
PubMed:Spectral characterization of iron(III) complexes of 2-benzoylpyridine N(4)-substituted thiosemicarbazones
PubMed:In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites
PubMed:Substituted pyridines: nonsteroidal inhibitors of human placental aromatase cytochrome P-450
PubMed:Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy
PubMed:Multidrug Delivery Systems Based on Human Serum Albumin for Combination Therapy with Three Anticancer Agents
PubMed:Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450
PubMed:Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents
PubMed:Transformation of a Cp*-iridium(III) precatalyst for water oxidation when exposed to oxidative stress
PubMed:Synthesis and solid state characterisation of mononuclear 2-benzoylpyridine N-methyl-N-phenylhydrazone palladium(II) complexes
PubMed:Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells
PubMed:Compositional and structural variety of diphenyllead(IV) complexes obtained by reaction of diphenyllead dichloride with thiosemicarbazones
PubMed:ROS-mediated cytotoxic effect of copper(II) hydrazone complexes against human glioma cells
PubMed:Aggregation tendency and reactivity toward AgX of cationic half-sandwich ruthenium(II) complexes bearing neutral N,O-ligands
PubMed:Exploring the effect of the ligand design on the interactions between [Ru(?(5)-C5H5)(PPh3)(N,O)][CF3SO3] complexes and human serum albumin
PubMed:Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer
PubMed:Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp
PubMed:Electrospray ionization mass spectrometry in the structural characterization of some diphenyllead(IV) thiosemicarbazonates
PubMed:[Tridentate N-N-N chelating systems as potential antitumor agents]
PubMed:Variable-Valent Re&tbd1;NAr Species. A Family of Re(VI)NAr Amide Complexes and Their Re(V)NAr Imine Precursors Related by Oxygen Atom Transfer
PubMed:Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats
PubMed:Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT
PubMed:In situ tetrazole templated chair-like decanuclear azido-cobalt(II) SMM containing both tetra- and octa-hedral Co(II) ions
PubMed:Carbonyl reductase activity exhibited by pig testicular 20 beta-hydroxysteroid dehydrogenase
PubMed:Remote functionalisation via sodium alkylamidozincate intermediates: access to unusual fluorenone and pyridyl ketone reactivity patterns
PubMed:Indirect determination of free cyanide in industrial waste effluent by atomic absorption spectrometry
 
Notes:
None found
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