EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(Z+E)-2,5-dimethyl tetrahydrofuran
tetrahydro-2,5-dimethylfuran

Supplier Sponsors

Name:2,5-dimethyloxolane
CAS Number: 1003-38-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:213-707-6
FDA UNII: T18L0V4N9I
Nikkaji Web:J133.069A
Beilstein Number:0102563
MDL:MFCD00005369
XlogP3:1.20 (est)
Molecular Weight:100.16084000
Formula:C6 H12 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Name:(2R,5R)-2,5-dimethyloxolane
CAS Number: 2390-94-5Picture of molecule3D/inchi
FDA UNII: XV3745SMWL
Nikkaji Web:J313.943C
XlogP3:1.20 (est)
Molecular Weight:100.16084000
Formula:C6 H12 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Name:(2S,5R)-2,5-dimethyloxolane
CAS Number: 2144-41-4Picture of molecule3D/inchi
FDA UNII: O7NB7572GU
Nikkaji Web:J100.738F
XlogP3:1.20 (est)
Molecular Weight:100.16084000
Formula:C6 H12 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Name:(2S,5S)-2,5-dimethyloxolane
CAS Number: 1003-38-9 (SS)Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J313.944A
XlogP3:1.20 (est)
Molecular Weight:100.16084000
Formula:C6 H12 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Flavourings:13.120 2,5-dimethyltetrahydrofuran
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00 sum of isomers
Food Chemicals Codex Listed: No
Specific Gravity:0.82700 to 0.83300 @ 25.00 °C.
Pounds per Gallon - (est).: 6.881 to 6.931
Refractive Index:1.40100 to 1.40700 @ 20.00 °C.
Boiling Point: 89.00 to 91.00 °C. @ 760.00 mm Hg
Vapor Pressure:62.088001 mmHg @ 25.00 °C. (est)
Vapor Density:3.45 ( Air = 1 )
Flash Point: 80.00 °F. TCC ( 26.67 °C. )
logP (o/w): 1.544 (est)
Soluble in:
 alcohol
 water, 8378 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2,5-Dimethyltetrahydrofuran, mixture of cis and trans 95%
Santa Cruz Biotechnology
For experimental / research use only.
(Z+E)-2,5-Dimethyltetrahydrofuran, mixture of cis and trans
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,5-Dimethyltetrahydrofuran 98% (mixture of cis and trans)
TCI AMERICA
For experimental / research use only.
(Z+E)-2,5-Dimethyltetrahydrofuran (stabilized with BHT) >98.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable.
R 38 - Irritating to skin.
S 02 - Keep out of the reach of children.
S 24 - Avoid contact with skin.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for (Z+E)-2,5-dimethyl tetrahydrofuran usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.0012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3200 (μg/person/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 3.0000015.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
Edible ices, including sherbet and sorbet (03.0): 3.0000015.00000
Processed fruit (04.1): 2.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 3.0000015.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 15.0000075.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 75 (FGE.75)[1] - Consideration of tetrahydrofuran derivatives and a furanone derivative evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008)
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :13855
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:3
2,5-dimethyloxolane
Chemidplus:0001003389
(2R,5R)-2,5-dimethyloxolane
Chemidplus:0002390945
(2S,5R)-2,5-dimethyloxolane
Chemidplus:0002144414
(2S,5S)-2,5-dimethyloxolane
 
References:
 2,5-dimethyloxolane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):13855
Pubchem (sid):134979592
 (2R,5R)-2,5-dimethyloxolane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):7567603
Pubchem (sid):40045340
 (2S,5R)-2,5-dimethyloxolane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):16508
Pubchem (sid):159746
 (2S,5S)-2,5-dimethyloxolane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):7567598
Pubchem (sid):40045335
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.19.5100
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 potato baked potato
Search Trop Picture
 
Synonyms:
2,5-dimethyl oxolane
2,5-dimethyloxolane
(Z+E)-2,5-dimethyltetrahydrofuran
2,5-dimethyltetrahydrofuran
 furan, tetrahydro-2,5-dimethyl-
 furan, tetrahydro-2,5-dimethyl- (8CI)(9CI)
 tetrahydro-2,5-dimethylfuran
 tetrahydrofuran, 2,5-dimethyl-
 
 
Notes:
None found
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