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Category:solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear oily liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.01700 @ 25.00 °C.
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| Melting Point: | 20.40 °C. @ 760.00 mm Hg
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| Boiling Point: | 235.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.010500 mmHg @ 25.00 °C. |
| Vapor Density: | 3.1 ( Air = 1 ) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | -0.830 |
| Soluble in: |
| | water, 1.00E+06 mg/L @ 20 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 1525 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: OTHER CHANGES
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
intraperitoneal-rat LD50 1070 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 26, Pg. 597, 1974.
oral-rabbit LD50 2531 mg/kg
BLOOD: OTHER CHANGES
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
oral-mouse LD50 2062 mg/kg
BLOOD: OTHER CHANGES
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
intraperitoneal-mouse LD50 1650 mg/kg
Toxicology and Applied Pharmacology. Vol. 49, Pg. 385, 1979.
oral-guinea pig LD50 1200 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: OTHER CHANGES
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-rat LCLo 15000 mg/m3/4H
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Inhalation Toxicology. Vol. 3, Pg. 379, 1991.
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Safety in Use Information:
| Category: | | solvents |
| Recommendation for 1,4-butane diol usage levels up to: | | | not for fragrance use.
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| Recommendation for 1,4-butane diol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to the introduction of a Fat (consumption) Reduction Factor for infants and children.
View page or View pdf
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Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils – Part I of III
View page or View pdf
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| EPI System: View |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):110-63-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :8064 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| butane-1,4-diol |
| Chemidplus:0000110634 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:110-63-4 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | agrisynth B1D | | 1,4- | butandiol | | | butane-1,4-diol | | 1,4- | butanediol | | 1,4- | butylene glycol | | 1,4- | dihydroxybutane | | | tetramethylene glycol | | 1,4- | tetramethylene glycol |
Articles:
| PubMed:Physical dependence on gamma-hydroxybutrate (GHB) prodrug 1,4-butanediol (1,4-BD): time course and severity of withdrawal in baboons. |
| PubMed:Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration. |
| PubMed:Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons. |
| PubMed:Thermal behavior and gelling interactions of Mesona Blumes gum and rice starch mixture. |
| PubMed:Cloning, expression and characterization of meso-2,3-butanediol dehydrogenase from Klebsiella pneumoniae. |
| PubMed:Monolithic column based on a poly(glycidyl methacrylate-co-4-vinylphenylboronic acid-co-ethylene dimethacrylate) copolymer for capillary liquid chromatography of small molecules and proteins. |
| PubMed:Determination of polyadipates migrating from lid gaskets of glass jars. Hydrolysis to adipic acid and measurement by LC-MS/MS. |
| PubMed:Electrochromatographic characterization of methacrylate ester-based monolith and capillary electrochromatography separation of flavonoids. |
| PubMed:Preparation of a neutral porous monolith and its evaluation in pressurized capillary electrochromatography with neutral and charged solutes. |
| PubMed:Xyloglucan xyloglucosyl transferases from barley (Hordeum vulgare L.) bind oligomeric and polymeric xyloglucan molecules in their acceptor binding sites. |
| PubMed:Preparation and evaluation of the highly cross-linked poly(1-hexadecane-co-trimethylolpropane trimethacrylate) monolithic column for capillary electrochromatography. |
| PubMed:Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons. |
| PubMed:Rapid determination of sterols in vegetable oils by CEC using methacrylate ester-based monolithic columns. |
| PubMed:Numerical and genetic analysis of polycyclic aromatic hydrocarbon-degrading mycobacteria. |
| PubMed:Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats. |
| PubMed:Interaction between 1,4-butanediol and ethanol on operant responding and the cardiovascular system. |
| PubMed:Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats. |
| PubMed:Chronic 1,4-butanediol treatment in rats: cross-tolerance to gamma-hydroxybutyrate and (+/-)-baclofen. |
| PubMed:Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors. |
| PubMed:The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies. |
| PubMed:NTP Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). |
| PubMed:Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol. |
| PubMed:Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature. |
| PubMed:Coma and respiratory depression following the ingestion of GHB and its precursors: three cases. |
| PubMed:Development of immunoassays for tyramine and tryptamine toxins of Phalaris aquatica L. |
| PubMed:Subacute oral toxicity of 1,4-butanediol in rats. |
| PubMed:Separation of immunoglobulin and transferrin from blood serum and plasma by metal chelate interaction chromatography. |
| PubMed:Separation of immunoglobulins and lactoferrin from cheese whey by chelating chromatography. |
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3D/inchi