EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

pentylene glycol
hydrolite 5 (Symrise)

Supplier Sponsors

Name:pentane-1,2-diol
CAS Number: 5343-92-0Picture of molecule3D/inchi
Other(deleted CASRN):91049-43-3
ECHA EINECS - REACH Pre-Reg:226-285-3
FDA UNII:50C1307PZG
Beilstein Number:1719151
MDL:MFCD00010736
XlogP3-AA:0.20 (est)
Molecular Weight:104.14904000
Formula:C5 H12 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:multi-functional cosmetic ingredient for skin and hair care
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96500 to 0.97500 @ 25.00 °C.
Pounds per Gallon - (est).: 8.030 to 8.113
Refractive Index:1.43400 to 1.44400 @ 20.00 °C.
Boiling Point: 198.00 to 199.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.057000 mmHg @ 25.00 °C. (est)
Flash Point: 220.00 °F. TCC ( 104.40 °C. ) (est)
logP (o/w): 0.011 (est)
Soluble in:
 water, 7.664e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
solvents
 
Suppliers:
BASF
1,2-Pentanediol
BOC Sciences
For experimental / research use only.
1,2-Pentanediol 95%
Connect Chemicals
Bio-pentylene glycol
ECSA Chemicals
PENTYLENE GLYCOL
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Kingyoung Bio Technical
Pentylene Glycol
Minasolve
MinaCare Pentiol (Pentylene glycol)
Odor: characteristic
Use: Pentylene glycol is a very widely used moizturing agent, also showing interesting antimicrobial boosting properties. Minasolve is a large producer of synthetic pentylene glycol of odouless and colourless quality for the cosmetic industry. Its quality is recognized by small, medium and large companies all over the world, including the luxury brands.
Minasolve
MinaCare Pentiol Green ECOCERT (Pentylene Glycol)
Odor: characteristic
Use: Pentylene Glycol is a very widely used moizturing agent, also showing interesting antimicrobial boosting properties. Minasolve is a large producer of synthetic Pentylene Glycol of odouless and colourless quality for the cosmetic industry. Its quality is recognized by small, medium and large companies all over the world, including the luxury brands.
Santa Cruz Biotechnology
For experimental / research use only.
1,2-Pentanediol
Sigma-Aldrich: Aldrich
For experimental / research use only.
1,2-Pentanediol 96%
Symrise
Hydrolite® 5 green
Odor: characteristic
Use: Hydrolite® 5 green perfectly fits into the sustainability strategy of Symrise. Within the context of this strategy, the company emphasizes the importance of comprehensive transparency that benefits customers and end consumers. In 2018 the company won several awards for its exceptional global environmental protection efforts (Carbon Disclosure Project) and climate targets as well as for its environmental and social engagement (Ethibel Sustainability Index). The company currently assesses 80 percent of its main suppliers according to sustainability criteria. “Every time we use raw materials in our product development, we look at their sustainability as well as their social and environmental added value,” said Eder Ramos Global President Cosmetic Ingredients Division of Symrise. “With Hydrolite® 5 green we have reached a further milestone, because it is entirely made from byproducts of a renewable source, the sugar cane.”
Symrise
Hydrolite® 5
Odor: characteristic
Use: Hydrolite® 5 is 1,2-pentanediol. Hydrolite® 5 is a colorless liquid with a charateristic intrinsic odor. Due to its chemical properties, Hydrolite® 5 is readily soluble in water and oil. Hydrolite® 5 improves the water-binding capability of the skin and increases the degree of hydration. Hydrolite® 5 is also outstanding for its antimicrobial properties.
TCI AMERICA
For experimental / research use only.
1,2-Pentanediol >98.0%(GC)
Vigon International
Hydrolite-5 (Pentylene Glycol)
Vigon International
HYDROLITE® 5 GREEN
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 12700 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(9), Pg. 14, 1973.

oral-rabbit LD50 3700 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(9), Pg. 14, 1973.

oral-mouse LD50 7400 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(9), Pg. 14, 1973.

oral-guinea pig LD50 5200 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(9), Pg. 14, 1973.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
multi-functional cosmetic ingredient for skin and hair care
Recommendation for pentylene glycol usage levels up to:
 not for fragrance use.
 
Recommendation for pentylene glycol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):5343-92-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :93000
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
pentane-1,2-diol
Chemidplus:0005343920
RTECS:SA0455000 for cas# 5343-92-0
 
References:
 pentane-1,2-diol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):93000
Pubchem (sid):135050899
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2905.39.9000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 hydrolite 5 (Symrise)
 hydrolite 5 green (Symrise)
1,2-pentane diol
 pentane-1,2-diol
1,2-pentanediol
 

Articles:

PubMed:Effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole: toward development of a general vehicle for controlled release.
PubMed:Safety assessment of 1,2-glycols as used in cosmetics.
PubMed:Dermal peptide delivery using enhancer molecules and colloidal carrier systems--part I: carnosine.
PubMed:The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols.
PubMed:Preservative system development for argan oil-loaded nanostructured lipid carriers.
PubMed:Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.
PubMed:Allergic contact dermatitis to ethylhexylglycerin and pentylene glycol.
PubMed:The influence of alcohol, propylene glycol and 1,2-pentanediol on the permeability of hydrophilic model drug through excised pig skin.
PubMed:Dermal and transdermal targeting of dihydroavenanthramide D using enhancer molecules and novel microemulsions.
PubMed:Contact dermatitis to pentylene glycol in a prescription cream for atopic dermatitis: case report.
PubMed:Modulation of dihydroavenanthramide D release and skin penetration by 1,2-alkanediols.
PubMed:Allergic contact dermatitis to pentylene glycol in a cosmetic cream.
PubMed:A novel TEM contrasting technique for extracellular polysaccharides in in vitro biofilms.
PubMed:Contact allergy to pentylene glycol.
PubMed:Purification, characterization, and gene cloning of glycerol dehydrogenase from Hansenula ofunaensis, and its expression for production of optically active diol.
PubMed:A family of nanoporous materials based on an amino acid backbone.
PubMed:Heat capacity studies of formation of micelle-like structure in aqueous solutions of some alkane polyols.
PubMed:Synthesis and properties of an acetaldehyde-derived oligonucleotide interstrand cross-link.
PubMed:Stereoselective oxidation of aliphatic diols and reduction of hydroxy-ketones with galactitol dehydrogenase from Rhodobacter sphaeroides D.
PubMed:Structures of carbohydrate-boronic acid complexes determined by NMR and molecular modelling in aqueous alkaline media.
PubMed:Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol.
PubMed:In vitro induction of apoptosis vs. necrosis by widely used preservatives: 2-phenoxyethanol, a mixture of isothiazolinones, imidazolidinyl urea and 1,2-pentanediol.
PubMed:Stereospecific synthesis of oligonucleotides containing crotonaldehyde adducts of deoxyguanosine.
PubMed:Effects of alcohols and diols on the phase behaviour of quaternary systems.
 
Notes:
None found
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