| Name: | (4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one |
| CAS Number: | 57-24-9 | 3D/inchi
|
| Other(deleted CASRN): | 101324-33-8 |
| ECHA EINECS - REACH Pre-Reg: | 200-319-7 |
| FDA UNII: | H9Y79VD43J |
| Nikkaji Web: | J4.576D |
| Beilstein Number: | 0052979 |
| MDL: | MFCD00005941 |
| XlogP3-AA: | 389.00 (est) |
| Molecular Weight: | 334.41874000 |
| Formula: | C21 H22 N2 O2 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:toxic natural substances
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless transparent crystals (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 287.00 °C. @ 760.00 mm Hg
|
| logP (o/w): | 1.930 |
| Soluble in: |
| | water, 160 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-bird - wild LD50 16 mg/kg Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
oral-cat LD50 500 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
intravenous-cat LDLo 330 ug/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
oral-chicken LDLo 30 mg/kg "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
oral-child TDLo 24 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BEHAVIORAL: GENERAL ANESTHETIC Pediatric Emergency Care. Vol. 15, Pg. 264, 1999.
intravenous-dog LD50 800 ug/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: TREMOR Journal of Pharmacology and Experimental Therapeutics. Vol. 126, Pg. 41, 1959.
oral-dog LD50 500 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
oral-duck LD50 3 mg/kg Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
oral-frog LDLo 2100 ug/kg "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
oral-human LDLo 30 mg/kg Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1073, 1966.
oral-man LDLo 30 mg/kg Pesticide Manual. Vol. 9, Pg. 771, 1991.
oral-man LDLo 5143 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA
CARDIAC: CHANGE IN RATE Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 269, 1992.
unreported-man LDLo 1103 ug/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
intramuscular-mouse LD50 628 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
intraperitoneal-mouse LD50 980 ug/kg BEHAVIORAL: TREMOR
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 176, 1960.
intravenous-mouse LD50 410 ug/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 204, 1960.
oral-mouse LD50 2 mg/kg Indian Journal of Experimental Biology. Vol. 19, Pg. 1075, 1981.
parenteral-mouse LD50 1060 ug/kg Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 657, 1961.
unreported-mouse LD50 500 ug/kg Igaku No Ayumi. Progress in Medicine. Vol. 112, Pg. 861, 1980.
oral-quail LD50 23 mg/kg Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
intravenous-rabbit LD50 400 ug/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 126, Pg. 41, 1959.
oral-rabbit LDLo 600 ug/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
intramuscular-rat LD50 1400 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
intraperitoneal-rat LD50 1100 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 239, 1936.
intravenous-rat LD50 582 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
oral-rat LD50 2350 ug/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 31, Pg. 113, 1942.
unreported-rat LDLo 1 mg/kg Pesticide Manual. Vol. 9, Pg. 771, 1991.
|
| Dermal Toxicity: |
subcutaneous-cat LDLo 250 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: IRRITABILITY Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 54, Pg. 234, 1974.
subcutaneous-chicken LDLo 3 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
subcutaneous-dog LDLo 350 ug/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
subcutaneous-duck LDLo 1 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
subcutaneous-frog LDLo 35 ug/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
subcutaneous-guinea pig LDLo 3200 ug/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1403, 1935.
subcutaneous-mouse LD50 474 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmaceutica Suecica. Vol. 7, Pg. 329, 1970.
subcutaneous-rabbit LDLo 400 ug/kg "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
subcutaneous-rat LD50 1200 ug/kg Russian Pharmacology and Toxicology Vol. 31, Pg. 260, 1968.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | toxic natural substances |
| Recommendation for (-)-strychnine usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for (-)-strychnine flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| EPA-Iris:IRIS |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):57-24-9 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :441071 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one |
| Chemidplus:0000057249 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:57-24-9 |
References:
| | (4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 57-24-9 |
| Pubchem (cid): | 441071 |
| Pubchem (sid): | 134970705 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | boomer-rid | | | certox | | (4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16- | decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one | | | dolco mouse cereal | | | gopher-gitter | | | hare-rid | | | strychnidin-10-one | | | strychnine or strychnine salts [UN1692] [poison] |
Articles:
| Info:Strychnine |
| PubMed:Dual mechanism for bitter avoidance in Drosophila. |
| PubMed:A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats. |
| PubMed:Bromethalin poisoning in a raccoon (Procyon lotor): diagnostic considerations and relevance to nontarget wildlife. |
| PubMed:Effects of Telfairia occidentalis (fluted pumpkin; Cucurbitaceae) in mouse models of convulsion, muscle relaxation, and depression. |
| PubMed:Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells. |
| PubMed:[Simultaneous determination of six adulterants in functional foods by high performance liquid chromatography with diode array detection]. |
| PubMed:Genetic analysis of the electrophysiological response to salicin, a bitter substance, in a polyphagous strain of the silkworm Bombyx mori. |
| PubMed:Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit. |
| PubMed:Screening of plant toxins in food, feed and botanicals using full-scan high-resolution (Orbitrap) mass spectrometry. |
| PubMed:Receptor agonism and antagonism of dietary bitter compounds. |
| PubMed:Prevalence of legal and illegal stimulating agents in sports. |
| PubMed:Consumption of bitter alkaloids in Drosophila melanogaster in multiple-choice test conditions. |
| PubMed:Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line - RPMI 8226. |
| PubMed:Simple and rapid extraction, separation, and detection of alkaloids in beverages. |
| PubMed:Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC. |
| PubMed:A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice. |
| PubMed:Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. |
| PubMed:The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells. |
| PubMed:[Interaction between strychnine and bovine serum albumin]. |
| PubMed:HPLC-UV method for nicotine, strychnine, and aconitine in dairy products. |
| PubMed:The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line. |
| PubMed:Development of a high performance liquid chromatography/mass spectroscopy method for the determination of strychnine concentrations in insects used to assess potential risks to insectivores. |
| PubMed:About the toxicity of some Strychnos species and their alkaloids. |
| PubMed:Tremorgenic neuromycotoxicosis in 2 dogs ascribed to the ingestion of penitrem A and possibly roquefortine in rice contaminated with Penicillium crustosum. |
| PubMed:Selective blockade of drug-induced place preference conditioning by ACPC, a functional NDMA-receptor antagonist. |
| PubMed:The selective glycine antagonist gavestinel lacks phencyclidine-like behavioral effects. |
| PubMed:A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines. |
| PubMed:Potentiation of paracetamol and carbon tetrachloride-induced hepatotoxicity in rodents by the food additive vanillin. |
| PubMed:Training and characterization of a quinine taste discrimination in rhesus monkeys. |
| PubMed:Behavioral specificity of the bitter taste gene Soa. |
| PubMed:Dizocilpine-like discriminative stimulus effects of competitive NMDA receptor antagonists in mice. |
| PubMed:Effects of convulsant and anticonvulsant agents on memory in squirrel monkeys. |
| PubMed:Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. |
| PubMed:Genetics of bitter perception in mice. |
| PubMed:Receptor mechanisms of bitter substances. |
| PubMed:Effects of convulsant ligands of the GABA-benzodiazepine receptor complex in conflict and learning tasks in mice. |
| PubMed:Taurine induces bicuculline/strychnine-insensitive dose-dependent inhibition of cortical visual evoked responses. |
| PubMed:Induction of feeding by 7-chlorokynurenic acid, a strychnine-insensitive glycine binding site antagonist. |
| PubMed:Hoffmann reflex from foreleg flexor nerves in cats: lateralization, picrotoxin, strychnine, crossed flexor reflex. |
| PubMed:Inhibitory neuromodulators do not alter the course of experimental hepatic encephalopathy. |
| PubMed:Selective enhancement of shock avoidance responding elicited by GABA blockade in the posterior hypothalamus of rats. |
| PubMed:MSH/ACTH 4-10 and aging effects on delayed response performance in rats. |
| PubMed:Methods of euthanasia in poultry and food-producing animals. |
| PubMed:Practical toxicologic diagnosis. |
| PubMed:A treatment of non-ketotic hyperglycinaemia. |
| PubMed:Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat. |
| PubMed:Pesticide poisoning of livestock: a review of cases investigated. |
| PubMed:Actions of clonidine on convulsions and behaviour. |
| PubMed:Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. |
| PubMed:[Clinical picture and diagnosis of botulism]. |
| PubMed:California bay oil. II. Biological effects of constituents. |
| PubMed:Time-dependent processes in memory storage. |
| PubMed:[Effect of kinetogenic drugs on internal inhibition in conditioned food reflexes of the 2d type]. |
| PubMed:[Not Available]. |
| PubMed:I. THE RELATION BETWEEN ATTACHMENT TO THE SUBSTRATUM AND INGESTION BY AMEBA IN STRYCHNINE SULFATE SOLUTION AND CONDITIONED MEDIA : II. BIOLOGICAL ASSAY OF CONDITIONED MEDIA. |
|