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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 67.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 273.00 °C. @ 760.00 mm Hg
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| Soluble in: |
| | water, 3.625e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-guinea pig LD50 2000 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 215, 1986.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for styrene glycol usage levels up to: | | | not for fragrance use.
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| Recommendation for styrene glycol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,2- | dihydroxy-1-phenyl ethane | | 1,2- | dihydroxy-1-phenylethane | | 1,2- | dihydroxyethyl benzene | | alpha,beta- | dihydroxyethyl benzene | | 1,2- | dihydroxyethylbenzene | | alpha,beta- | dihydroxyethylbenzene | | 1,2- | ethanediol, 1-phenyl- | | 1,2- | ethanediol, phenyl- | | 1- | fenyl-1,2-ethandiol | | | fenylglycol | | | phenyl ethane diol | | | phenyl ethane-1,2-diol | | 1- | phenyl ethylene glycol | | | phenyl glycol | | | phenyl glycol ether | | (±)-1- | phenyl-1,2-ethane diol | | | phenyl-1,2-ethanediol | | | phenylethane-1,2-diol | | 1- | phenylethane-1,2-diol | | | phenylethylene glycol | | 1- | phenylethylene glycol | | | styrolyl alcohol |
Articles:
| PubMed:Improving Gluconobacter oxydans performance in the in situ removal of the inhibitor for asymmetric resolution of racemic 1-phenyl-1,2-ethanediol. |
| PubMed:Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. |
| PubMed:Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes. |
| PubMed:By-passing the refinery for production of high-value BTX derivatives. |
| PubMed:Optimized expression of (S)-carbonyl reductase in Pichia pastoris for efficient production of (S)-1-phenyl-1, 2-ethanediol. |
| PubMed:Microbial production of the aromatic building-blocks (S)-styrene oxide and (R)-1,2-phenylethanediol from renewable resources. |
| PubMed:Enantioconvergent biohydrolysis of racemic styrene oxide to R-phenyl-1, 2-ethanediol by a newly isolated filamentous fungus Aspergillus tubingensis TF1. |
| PubMed:Highly enantioselective oxidation of racemic phenyl-1,2-ethanediol to optically pure (R)-(-)-mandelic acid by a newly isolated Brevibacterium lutescens CCZU12-1. |
| PubMed:Cooperative effects for CYP2E1 differ between styrene and its metabolites. |
| PubMed:Efficient one-step production of (S)-1-phenyl-1,2-ethanediol from (R)-enantiomer plus NAD(+)-NADPH in-situ regeneration using engineered Escherichia coli. |
| PubMed:Essential oils and fatty acids composition of Tunisian and Indian cumin (Cuminum cyminum L.) seeds: a comparative study. |
| PubMed:Novel anti-Prelog stereospecific carbonyl reductases from Candida parapsilosis for asymmetric reduction of prochiral ketones. |
| PubMed:Identification and quantification of lignans in wheat bran by gas chromatography-electron capture detection. |
| PubMed:Carbonyl reductase SCRII from Candida parapsilosis catalyzes anti-Prelog reaction to (S)-1-phenyl-1,2-ethanediol with absolute stereochemical selectivity. |
| PubMed:Detection of phenolic metabolites of styrene in mouse liver and lung microsomal incubations. |
| PubMed:Highly enantioselective reduction of 2-hydroxy-1-phenylethanone to enantiopure (R)-phenyl-1,2-ethanediol using Saccharomyces cerevisiae of remarkable reaction stability. |
| PubMed:Enhancement of Candida parapsilosis catalyzing deracemization of (R,S)-1-phenyl-1,2-ethanediol to its (S)-enantiomer by a highly productive "two-in-one" resin-based in situ product removal strategy. |
| PubMed:[Gene cloning and expression of a novel (S)-specific carbonyl reductase]. |
| PubMed:[Construction of an enzyme-coupled system consisting of (R)- and (S)-specific carbonyl reductases for one-step preparation of (S)-1-phenyl-1,2-ethanediol]. |
| PubMed:Improved production of (R)-1-phenyl-1,2-ethanediol by a codon-optimized R-specific carbonyl reductase from Candida parapsilosis in Escherichia coli. |
| PubMed:A new strategy to improve the efficiency and sustainability of Candida parapsilosis catalyzing deracemization of (R,S)-1-phenyl-1,2-ethanediol under non-growing conditions: increase of NADPH availability. |
| PubMed:An approach based on liquid chromatography/electrospray ionization-mass spectrometry to detect diol metabolites as biomarkers of exposure to styrene and 1,3-butadiene. |
| PubMed:Genetic effects and biotoxicity monitoring of occupational styrene exposure. |
| PubMed:Biosynthesis of (R)-phenyl-1,2-ethanediol from racemic styrene oxide by using bacterial and marine fish epoxide hydrolases. |
| PubMed:A novel NADH-dependent carbonyl reductase with unusual stereoselectivity for (R)-specific reduction from an (S)-1-phenyl-1,2-ethanediol-producing micro-organism: purification and characterization. |
| PubMed:Simultaneous determination of phenylglyoxylic acid, mandelic acid, styrene glycol and hippuric acid in primary culture of rat hepatocytes incubate by high-performance liquid chromatography. |
| PubMed:Enantioconvergent production of (R)-1-phenyl-1,2-ethanediol from styrene oxide by combining the Solanum tuberosum and an evolved Agrobacterium radiobacter AD1 epoxide hydrolases. |
| PubMed:Colorimetric assays for quantitative analysis and screening of epoxide hydrolase activity. |
| PubMed:Enzymatic resolution of racemic phenyloxirane by a novel epoxide hydrolase from Aspergillus niger SQ-6 and its fed-batch fermentation. |
| PubMed:Protein engineering of epoxide hydrolase from Agrobacterium radiobacter AD1 for enhanced activity and enantioselective production of (R)-1-phenylethane-1,2-diol. |
| PubMed:Block copolymers of ethylene oxide and phenyl glycidyl ether: micellization, gelation, and drug solubilization. |
| PubMed:Effects of pregnancy, age and sex in the metabolism of styrene in rat liver in relation to the regulation of cytochrome P450 enzymes. |
| PubMed:A novel approach based on solid phase microextraction gas chromatography and mass spectrometry to the determination of highly reactive organic compounds in cells cultures: styrene oxide. |
| PubMed:A spectrophotometric assay for measuring and detecting an epoxide hydrolase activity. |
| PubMed:[Hydrophobic membrane chromatography for fast purification of biological macromolecules]. |
| PubMed:Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat. |
| PubMed:DNA single strand breaks induced by low levels of occupational exposure to styrene: the gap between standards and reality. |
| PubMed:Stereochemical metabolism of styrene in volunteers. |
| PubMed:Metabolism of the styrene metabolite 4-vinylphenol by rat and mouse liver and lung. |
| PubMed:Toxicity and biodegradation of products from polyester hydrolysis. |
| PubMed:Incorporation of an aldehyde function in oligonucleotides. |
| PubMed:Metabolism of styrene oxide to styrene glycol in enriched mouse clara-cell preparations. |
| PubMed:Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid. |
| PubMed:Effect of styrene on monoamine oxidase B activity in rat brain. |
| PubMed:The 5-nitrofuran-2-ylmethylidene group as a potential bioreductively activated prodrug system for diol-containing drugs. |
| PubMed:Influence of duration of exposure to styrene oxide on sister chromatid exchanges and cell-cycle kinetics in cultured human blood lymphocytes in vitro. |
| PubMed:Metabolism of styrene oxide to styrene glycol by mouse liver and lung. |
| PubMed:Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. |
| PubMed:Determination of albumin and hemoglobin adducts in workers exposed to styrene and styrene oxide. |
| PubMed:Effects of simultaneous administration of ethanol on styrene metabolism under fed and fasted conditions in the perfused rat liver. |
| PubMed:Assessment of the neurotoxicity of styrene, styrene oxide, and styrene glycol in primary cultures of motor and sensory neurons. |
| PubMed:Partial conversion of cinnamic acid into styrene by growing cultures and cell-free extracts of the yeast Cryptococcus elinovii. |
| PubMed:Microbial metabolism and biotransformations of styrene. |
| PubMed:Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. |
| PubMed:CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. |
| PubMed:Review of the metabolic fate of styrene. |
| PubMed:Monitoring occupational exposure to styrene from hemoglobin adducts and metabolites in blood. |
| PubMed:Effects of different styrene metabolites on cytotoxicity, sister-chromatid exchanges and cell-cycle kinetics in human whole blood lymphocytes in vitro. |
| PubMed:Monitoring of exposure to styrene oxide by GC-MS analysis of phenylhydroxyethyl esters in hemoglobin. |
| PubMed:Dose-dependent genotoxic effects of styrene on human blood lymphocytes and the relationship to its oxidative and metabolic effects. |
| PubMed:Characterization of the human cytochrome P450 isozymes responsible for styrene metabolism. |
| PubMed:Single-strand breaks, chromosome aberrations, sister-chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics. |
| PubMed:Dichlorotetrafluoroacetone as a derivatisation reagent in the analysis of mandelic acids in human urine. |
| PubMed:Analysis of styrene oxide-globin adducts based upon reaction with Raney nickel. |
| PubMed:The stereoselectivity of 1,2-phenylethanediol and mandelic acid metabolism and disposition in the rat. |
| PubMed:Effect of ethanol on the urinary excretion of mandelic and phenylglyoxylic acids after human exposure to styrene. |
| PubMed:Biological monitoring of styrene: a review. |
| PubMed:Single-strand breaks in DNA of peripheral lymphocytes of styrene-exposed workers. |
| PubMed:Kinetics of styrene in workers from a plastics industry after controlled exposure: a comparison with subjects not previously exposed. |
| PubMed:Effect of in vitro exposure to styrene, styrene oxide, and other structurally related compounds on murine cell-mediated immunity. |
| PubMed:The formation of styrene glutathione adducts catalyzed by prostaglandin H synthase. A possible new mechanism for the formation of glutathione conjugates. |
| PubMed:Biological monitoring of styrene metabolites in blood. |
| PubMed:Mutagenic action of styrene and its metabolites. II. Genotoxic activity of styrene, styrene oxide, styrene glycol and benzoic acid tested with the SOS chromotest. |
| PubMed:Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons. |
| PubMed:Effect of blood on styrene oxidation in perfused rat liver. |
| PubMed:Activation of styrene to styrene oxide in hepatocytes and subcellular fractions of rat liver. |
| PubMed:Uptake, distribution, metabolism, and elimination of styrene in man. A comparison between single exposure and co-exposure with acetone. |
| PubMed:Occurrence of styrene-7,8-oxide and styrene glycol in mouse after the administration of styrene. |
| PubMed:Exposure to styrene. Uptake, distribution, metabolism and elimination in man. |
| PubMed:Cytosolic epoxide hydrolase in fetal and adult human liver. |
| PubMed:Tissue distribution of styrene, styrene glycol and more polar styrene metabolites in the mouse. |
| PubMed:Styrene oxide metabolism in rhesus monkey liver: enzyme activities in subcellular fractions and in isolated hepatocytes. |
| PubMed:Microsomal epoxide hydrolase in different rat strains. |
| PubMed:The effect of alcoholic cirrhosis on the activities of microsomal aldrin epoxidase, 7-ethoxycoumarin O-de-ethylase and epoxide hydrolase, and on the concentrations of reduced glutathione in human liver. |
| PubMed:Stereochemistry in the oxidative metabolism of styrene by hepatic microsomes. |
| PubMed:Isolation and incorporation of rabbit liver epoxide hydrase into phospholipid vesicles. |
| PubMed:Epoxide hydrase in Trypanosoma cruzi epimastigotes. |
| PubMed:The fate of intratracheally instilled 3H-styrene oxide in the isolated perfused rat lungs. |
| PubMed:Cytogenetic effects of styrene and styrene oxide. |
| PubMed:A very sensitive gas chromatographic method for the evaluation of styrene oxidase and styrene oxide hydratase activities. |
| PubMed:The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites. |
| PubMed:A simple method for purification of epoxide hydratase from rat liver. |
| PubMed:Characterization of rat lung epoxide (styrene oxide) hydrase with a modified radioactive assay of improved sensitivity. |
| PubMed:Action of styrene and its metabolites sytrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo. |
| PubMed:A study on the mutagenic activity of styrene and styrene oxide. |
| PubMed:Determination of vicinal hydroxyl groups in poly(vinyl alcohol) (PVA). |
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3D/inchi