EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

1-methyl-2-pyrrolidinone
2-pyrrolidone, 1-methyl

Supplier Sponsors

Name:1-methylpyrrolidin-2-one
CAS Number: 872-50-4Picture of molecule3D/inchi
Other(deleted CASRN):26138-58-9
ECHA EINECS - REACH Pre-Reg:212-828-1
FDA UNII: JR9CE63FPM
Nikkaji Web:J26.033I
Beilstein Number:106420
MDL:MFCD00003193
XlogP3:-0.50 (est)
Molecular Weight:99.13293000
Formula:C5 H9 N O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Name:1-methylpyrrolidin-2-one
CAS Number: 51013-18-4Picture of molecule3D/inchi
FDA UNII: Search
Molecular Weight:99.13293000
Formula:C5 H9 N O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):872-50-4 ; N-METHYL-2-PYRROLIDONE
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: -25.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 202.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.345000 mmHg @ 25.00 °C. (est)
Vapor Density:3.4 ( Air = 1 )
Flash Point: 187.00 °F. TCC ( 86.10 °C. ) (est)
logP (o/w): -0.380
Soluble in:
 water, 1.00E+06 mg/L @ 25 °C (exp)
 water, 2.483e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: solvents
surfactants
 
Suppliers:
BOC Sciences
For experimental / research use only.
N-Methyl-2-pyrrolidone
Odor: characteristic
Use: N-Methyl-2-pyrrolidone is used as a versatile industrial solvent.
Covalent Chemical
N-methyl pyrrolidone
Eastman Chemical
N-Methyl-2-Pyrrolidone (NMP)
sds
Odor: characteristic
Use: N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid. NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability. It is used as a solvent for engineering polymers and coating resins. The polar nature and the low surface tension of NMP makes it also an excellent cleaning medium and paint stripping solvent.
ECSA Chemicals
N-METHYLPYRROLIDONE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Glentham Life Sciences
1-Methyl-2-pyrrolidinone
Indis NV
For experimental / research use only.
N-Methyl-2-Pyrrolidone
LyondellBasell Industries
N-Methyl-2-pyrrolidone
Penta International
1-METHYL-2-PYRROLIDINONE
Santa Cruz Biotechnology
For experimental / research use only.
1-Methyl-2-pyrrolidinone ≥99%
Shiva Chemicals and Pharmaceuticals
n Methyl Pyrrolidone
Sigma-Aldrich
For experimental / research use only.
1-Methyl-2-pyrrolidinone anhydrous, 99.5%
Silver Fern Chemical
n-Methylpyrrolidone
Odor: characteristic
Use: N-Methylpyrrolidone is commonly used as a solvent for resins and acetylene, a pigment dispersant, in petroleum, microelectronics, plastics, textiles, agrochemicals, and pharmaceuticals.
Taminco (Eastman)
n-methylpyrrolidone
TCI AMERICA
For experimental / research use only.
1-Methyl-2-pyrrolidinone >99.0%(GC)
sds
Universal Preserv-A-Chem Inc.
MICROPURE EG
Odor: characteristic
Use: NMP is used to recover certain hydrocarbons generated in the processing petrochemicals, such as the recovery of 1,3-butadiene and acetylene. It is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities. Due to its good solvency properties NMP is used to dissolve a wide range of polymers. It also used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 63300 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.

intraperitoneal-mouse LD50 3050 mg/kg
United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1087-0695

intravenous-mouse LD50 54500 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.

oral-mouse LD50 5130 mg/kg
United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1087-0695

intraperitoneal-rat LD50 2472 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.

intravenous-rat LD50 80500 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.

oral-rat LD50 3914 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.

unreported-rat LD50 7000 mg/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 408, 1969.

Dermal Toxicity:
skin-rabbit LD50 8000 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 84, 1974.

subcutaneous-rat LD50 > 2000 mg/kg
United States Patent Document. Vol. #4882359

Inhalation Toxicity:
inhalation-rat LCLo 1000 mg/m3
National Technical Information Service. Vol. OTS0534725
 
Safety in Use Information:
Category:
solvents
Recommendation for 1-methyl-2-pyrrolidinone usage levels up to:
 not for fragrance use.
 
Recommendation for 1-methyl-2-pyrrolidinone flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 7th list of substances for food contact materials
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):872-50-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :13387
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1-methylpyrrolidin-2-one
Chemidplus:0000872504
EPA/NOAA CAMEO:hazardous materials
RTECS:872-50-4
1-methylpyrrolidin-2-one
Chemidplus:0051013184
 
References:
 1-methylpyrrolidin-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:872-50-4
Pubchem (cid):13387
Pubchem (sid):134980916
 1-methylpyrrolidin-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:51013-18-4
Pubchem (cid):13387
Pubchem (sid):135117211
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C11118
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.79.2000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 M-pyrol
N-methyl pyrrolidone
N-methyl-2-ketopyrrolidine
N-methyl-2-pyrolidinone
N-methyl-2-pyrrolidinone
1-methyl-2-pyrrolidone
N-methyl-2-pyrrolidone
N-methyl-a-pyrrolidinone
N-methyl-a-pyrrolidone
1-methyl-pyrrolidin-2-one
N-methyl-pyrrolidone
N-methylbutyrolactam
1-methylpyrrolidin-2-one
N-methylpyrrolidin-2-one
 methylpyrrolidinone
N-methylpyrrolidinone
N-methylpyrrolidione
N-methylpyrrolidone
 methylpyrrolidone, N-
 pyrrolidin-2-one, 1-methyl-
2-pyrrolidinone, 1-methyl-
 pyrrolidinone, methyl-
2-pyrrolidinone, methyl-
2-pyrrolidone, 1-methyl
 

Articles:

PubMed:Homogeneous ring opening graft polymerization of ɛ-caprolactone onto xylan in dual polar aprotic solvents.
PubMed:Star-shaped poly(L-lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: synthesis, self-assembly, singlet oxygen research and recognition properties.
PubMed:Direct synthesis of α-trifluoromethyl ketone from (hetero)arylacetylene: design, intermediate trapping, and mechanistic investigations.
PubMed:Effective liquid-phase exfoliation and sodium ion battery application of MoS2 nanosheets.
PubMed:Liquid-phase exfoliation of graphene in organic solvents with addition of naphthalene.
PubMed:Ultrahigh PEMFC performance of a thin-film, dual-electrode assembly with tailored electrode morphology.
PubMed:Carbon nanotube poroshell silica as a novel stationary phase for fast HPLC analysis of monoclonal antibodies.
PubMed:Development and pharmacokinetic evaluation of a curcumin co-solvent formulation.
PubMed:Fouling mitigation in humic acid ultrafiltration using polysulfone/SAPO-34 mixed matrix membrane.
PubMed:Chemical and biological characterization of wastewater generated from hydrothermal liquefaction of Spirulina.
PubMed:Noninvasive characterization of the effect of varying PLGA molecular weight blends on in situ forming implant behavior using ultrasound imaging.
PubMed:Non-covalent functionalisation of monolithic silica for the development of carbon nanotube HPLC stationary phases.
PubMed:Porosity and mechanically optimized PLGA based in situ hardening systems.
PubMed:Effects of pentacene-doped PEDOT:PSS as a hole-conducting layer on the performance characteristics of polymer photovoltaic cells.
PubMed:Partial dissolution of ACQ-treated wood in lithium chloride/N-methyl-2-pyrrolidinone: separation of copper from potential lignocellulosic feedstocks.
PubMed:Delivery of atovaquone and proguanil across sublingual membranes, in vitro.
PubMed:Rare earth fluoride nanoparticles obtained using charge transfer complexes: a versatile and efficient route toward colloidal suspensions and monolithic transparent xerogels.
PubMed:Effects of electrochemical reduction reactions on the biodegradation of recalcitrant organic compounds (ROCs) and bacterial community diversity.
PubMed:Facile synthesis of MOF-177 by a sonochemical method using 1-methyl-2-pyrrolidinone as a solvent.
PubMed:Characterization of formulation parameters affecting low molecular weight drug release from in situ forming drug delivery systems.
PubMed:Noninvasive characterization of in situ forming implants using diagnostic ultrasound.
PubMed:SAXS and NMR analysis for the cast solvent effect on sPEEK membrane properties.
PubMed:Pyrolysis of waste polypropylene and characterisation of tar.
PubMed:The use of oxygen uptake rate to monitor discovery of microbial and enzymatic biocatalysts.
PubMed:Human bone derived cell culture on PLGA flat sheet membranes of different lactide:glycolide ratio.
PubMed:Kinetics of amide formation through carbodiimide/N-hydroxybenzotriazole (HOBt) couplings.
PubMed:[Discharge ion mobility spectrometry of ketonic organic compounds].
PubMed:Control of EOF in CE by different ways of application of radial electric field.
PubMed:Phase separation micromolding: a new generic approach for microstructuring various materials.
PubMed:Poly(lactic-co-glycolic acid) hollow fibre membranes for use as a tissue engineering scaffold.
PubMed:Unexpected reaction of beta-cyclodextrin tosylate with pyrrolidinones.
PubMed:Examination of soil contaminated by coal-liquids by size exclusion chromatography in 1-methyl-2-pyrrolidinone solution to evaluate interference from humic and fulvic acids and extracts from peat.
PubMed:[Effect of tegaserod on the serotonin content in rat ileocaecal mucosa under partial restraint stress].
PubMed:Affinity enhancement bivalent morpholino for pretargeting: initial evidence by surface plasmon resonance.
PubMed:Relevance of Frank's solvent classification as typically aqueous and typically non-aqueous to activities of firefly luciferase, alcohol dehydrogenase, and alpha-chymotrypsin in aqueous binaries.
PubMed:Wetting kinetics of modified polyimide surfaces: interactions with polar solvents.
PubMed:Estimation of the molecular mass range of the tar from pyrolysis of casein by gas chromatography-mass spectrometry, probe mass spectrometry and size exclusion chromatography with 1-methyl-2-pyrrolidinone as eluent.
PubMed:Use of an 8(1)3(2) asymmetrical factorial design for the in vitro evaluation of ondansetron permeation through human epidermis.
PubMed:Thin-layer chromatography of pitch and a petroleum vacuum residue. Relation between mobility and molecular size shown by size-exclusion chromatography.
PubMed:Size-exclusion chromatography of large molecules from coal liquids, petroleum residues, soots, biomass tars and humic substances.
PubMed:Through-shell alkyllithium additions and borane reductions.
PubMed:The effect of Pluronic on the protein release kinetics of an injectable drug delivery system.
PubMed:Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process.
PubMed:Dermal exposure to aqueous solutions of N-methyl pyrrolidone.
PubMed:Pyrolysis-gas chromatography/mass spectrometry of fractions separated from a low-temperature coal tar: an attempt to develop a general method for characterising structures and compositions of heavy hydrocarbon liquids.
PubMed:A new, efficient glycosylation method for oligosaccharide synthesis under neutral conditions: preparation and use of new DISAL donors.
PubMed:Study of the polymerization of anthracene oil with AlCl3 by chromatography and related techniques.
PubMed:Liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry determination of N-methylpyrrolidinone in riverine biofilms.
PubMed:Structural characterisation of Baltic amber and its solvent extracts by several mass spectrometric methods.
PubMed:Syntheses and characterization of anti-inflammatory dinuclear and mononuclear zinc indomethacin complexes. Crystal structures of [Zn2(indomethacin)4(L)2] (L = N,N-dimethylacetamide, pyridine, 1-methyl-2-pyrrolidinone) and [Zn(indomethacin)2(L1)2] (L1 = ethanol, methanol).
PubMed:HPTLC screening assay for urinary cotinine as biomarker of environmental tobacco smoke exposure among male adolescents.
PubMed:Identification of organically associated trace elements in wood and coal by inductively coupled plasma mass spectrometry.
PubMed:Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer.
PubMed:Photodynamic activities and biodistribution of fluorinated zinc phthalocyanine derivatives in the murine EMT-6 tumour model.
PubMed:Synthesis, Structure, and Thiolysis Reactions of Pyridine Soluble Alkaline Earth and Yttrium Thiolates.
PubMed:Determination of 5-hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide in human urine.
PubMed:1-Methyl-2-pyrrolidinone (NMP) does not induce structural and numerical chromosomal aberrations in vivo.
PubMed:Characterization of polymorphs and solvates of 3-amino-1-(m-trifluoromethylphenyl)-6-methyl-1H-pyridazin-4-one.
PubMed:Synthesis of insulin-like growth factor I using N-methyl pyrrolidinone as the coupling solvent and trifluoromethane sulphonic acid cleavage from the resin.
PubMed:Transdermal absorption of radioprotectors using permeation-enhancing vehicles.
PubMed:Induction of chromosome loss by mixtures of organic solvents including neurotoxins.
PubMed:Aprotic polar solvents that affect porcine brain tubulin aggregation in vitro induce aneuploidy in yeast cells growing at low temperatures.
PubMed:Investigations of aneuploidy-inducing chemical combinations in Saccharomyces cerevisiae.
PubMed:Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1-methyl-2-pyrrolidinone and 2-pyrrolidinone.
PubMed:Nonheritable resistance to chloramphenicol and other antibiotics induced by salicylates and other chemotactic repellents in Escherichia coli K-12.
PubMed:Degradation of chlorthalidone in methanol: kinetics and stabilization.
 
Notes:
None found
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