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Category:nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 98.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 309.00 to 310.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000057 mmHg @ 25.00 °C. (est) |
| Flash Point: | 311.00 °F. TCC ( 155.20 °C. ) (est)
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| logP (o/w): | -1.721 (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | nutrient supplements |
| Recommendation for calcium citrate malate usage levels up to: | | | not for fragrance use.
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| Recommendation for calcium citrate malate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Calcium citrate malate as source for calcium for use in foods for Particular Nutritional Uses and in foods for the general population (including food supplements)[1] - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing aids and Materials in Contact with food (AFC)
View page or View pdf
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| ClinicalTrials.gov:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :132456 |
| National Institute of Allergy and Infectious Diseases:Data |
| tetracalcium; 2-hydroxybutanedioate; 2-hydroxypropane-1,2,3-tricarboxylate |
| Chemidplus:0142606539 |
References:
| | tetracalcium; 2-hydroxybutanedioate; 2-hydroxypropane-1,2,3-tricarboxylate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 132456 |
| Pubchem (sid): | 135088044 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | calcium 2-hydroxybutanedioate 2-hydroxypropane-1,2,3-tricarboxylate (4:1:2) | | 2- | hydroxy-1,2,3-propanetricarboxylic acid calcium salt, mixt. with hydroxybutanedioic acid calcium salt | | 1,2,3- | propanetricarboxylic acid, 2-hydroxy-, calcium salt, mixt. with hydroxybutanedioic acid calcium salt | | | tetracalcium; 2-hydroxybutanedioate; 2-hydroxypropane-1,2,3-tricarboxylate |
Articles:
| PubMed:An in-vitro assessment of erosive potential of a calcium-fortified fruit juice. |
| PubMed:Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate. |
| PubMed:Effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing gastrectomy. |
| PubMed:[Nutrition and bone health. Food for specified health use (FOSHU) and bone health]. |
| PubMed:The health benefits of calcium citrate malate: a review of the supporting science. |
| PubMed:Calcium supplementation and bone mineral accretion in adolescent girls: an 18-mo randomized controlled trial with 2-y follow-up. |
| PubMed:Calcium retention in adolescent boys on a range of controlled calcium intakes. |
| PubMed:Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. |
| PubMed:I understand that older women should take 1,000-1,500 mg of calcium every day. I am 60, and my doctor recommends calcium citrate. However, a physical therapist I am seeing for a back problem says to take Os Cal. Which is best? |
| PubMed:Calcium fortification systems differ in bioavailability. |
| PubMed:Calcium and protein in bone health. |
| PubMed:Interaction of dietary calcium and protein in bone health in humans. |
| PubMed:Conserved residues R420 and Q428 in a cytoplasmic loop of the citrate/malate transporter CimH of Bacillus subtilis are accessible from the external face of the membrane. |
| PubMed:Relative bioavailability of calcium-rich dietary sources in the elderly. |
| PubMed:An investigation of calcium citrate-malate as a calcium source for young broiler chicks. |
| PubMed:Selenium intakes, absorption, retention, and status in adolescent girls. |
| PubMed:Absorption of calcium fumarate salts is equivalent to other calcium salts when measured in the rat model. |
| PubMed:Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women. |
| PubMed:Fate of salmonellae in calcium-supplemented orange juice at refrigeration temperature. |
| PubMed:Calcium and vitamin D supplements reduce tooth loss in the elderly. |
| PubMed:Survival of salmonellae in pasteurized, refrigerated calcium-fortified orange juice. |
| PubMed:Comparative absorption of calcium sources and calcium citrate malate for the prevention of osteoporosis. |
| PubMed:Iron status, menarche, and calcium supplementation in adolescent girls. |
| PubMed:Comparison of erosion of dental enamel by four drinks using an intra-oral applicance. |
| PubMed:Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. |
| PubMed:Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females. |
| PubMed:Zinc balance in adolescent females consuming a low- or high-calcium diet. |
| PubMed:Effect of dietary calcium on urinary oxalate excretion after oxalate loads. |
| PubMed:Calcium absorption from apple and orange juice fortified with calcium citrate malate (CCM). |
| PubMed:Magnesium balance in adolescent females consuming a low- or high-calcium diet. |
| PubMed:Lessening dental erosive potential by product modification. |
| PubMed:The effect of calcium supplementation and Tanner stage on bone density, content and area in teenage women. |
| PubMed:Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium. |
| PubMed:Effect of calcium supplementation on blood pressure in children. |
| PubMed:Supplementation trials with calcium citrate malate: evidence in favor of increasing the calcium RDA during childhood and adolescence. |
| PubMed:Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. |
| PubMed:Effect of age, calcium source, and radiolabeling method on whole body 47Ca retention in the rat. |
| PubMed:Calcium supplementation and bone mineral density in adolescent girls. |
| PubMed:Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men. |
| PubMed:Calcium supplementation and increases in bone mineral density in children. |
| PubMed:Stone-forming potential of milk or calcium-fortified orange juice in idiopathic hypercalciuric adults. |
| PubMed:Lactose, calcium source and age affect calcium bioavailability in rats. |
| PubMed:Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. |
| PubMed:A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. |
| PubMed:Effect of calcium citrate-malate on skeletal development in young, growing rats. |
| PubMed:Effects of different calcium sources on iron absorption in postmenopausal women. |
| PubMed:Calcium absorption in children estimated from single and double stable calcium isotope techniques. |
| PubMed:Calcium absorption from a new calcium delivery system (CCM). |
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3D/inchi