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Category:nutrient supplements, EFSA concludes: use is of safety concern.
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | -0.928 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 400 mg/kg French Medicament Patent Document. Vol. #1260M
intravenous-mouse LD50 105 mg/kg French Medicament Patent Document. Vol. #1260M
oral-mouse LD50 > 2000 mg/kg French Medicament Patent Document. Vol. #1260M
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | nutrient supplements, EFSA concludes: use is of safety concern. |
| Recommendation for choline orotate (salt) usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for choline orotate (salt) flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Orotic acid salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :90484 |
| National Institute of Allergy and Infectious Diseases:Data |
| 2,4-dioxo-1H-pyrimidine-6-carboxylate; 2-hydroxyethyl(trimethyl)azanium |
| Chemidplus:0024381495 |
References:
| | 2,4-dioxo-1H-pyrimidine-6-carboxylate; 2-hydroxyethyl(trimethyl)azanium |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 90484 |
| Pubchem (sid): | 135045003 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cholergol | | | choline 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate | | 2,4- | dioxo-1H-pyrimidine-6-carboxylate; 2-hydroxyethyl(trimethyl)azanium | | 2- | hydroxy-n,n,n-trimethylethanaminium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate | | | orotic acid choline salt | | | rufai B 13 |
Articles:
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