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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 97.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 83.00 to 88.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 129.00 °C. @ 24.00 mm Hg
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| Vapor Pressure: | 5.200000 mmHg @ 25.00 °C. |
| Vapor Density: | 6.1 ( Air = 1 ) |
| Flash Point: | 302.00 °F. TCC ( 150.00 °C. )
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| logP (o/w): | 1.010 |
| Soluble in: |
| | alcohol | | | water, 7832 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 21/22 - Harmful in contact with skin and if swallowed.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 36/39 - Wear suitable clothing and eye/face protection.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 2450 mg/kg
National Technical Information Service. Vol. OTS0533750
intraperitoneal-rat LD50 800 mg/kg
National Technical Information Service. Vol. OTS0533572
oral-rabbit LD50 3925 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(1), Pg. 49, 1987.
oral-mouse LD50 3400 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(1), Pg. 49, 1987.
intraperitoneal-mouse LD50 300 mg/kg
National Technical Information Service. Vol. AD277-689
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| Dermal Toxicity: |
skin-guinea pig LD50 > 1000 mg/kg
National Technical Information Service. Vol. OTS0533572
subcutaneous-rat LD50 7000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(1), Pg. 49, 1987.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for acetoacetanilide usage levels up to: | | | not for fragrance use.
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| Recommendation for acetoacetanilide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | AAA | | | AAN | | | acetoacetamidobenzene | | | acetoacetanilid | | | acetoacetic acid anilide | | | acetoacetic anilide | | | acetoacetyl aniline | | (( | acetoacetyl)amino) benzene | | (( | acetoacetyl)amino)benzene | | | acetoacetylaminobenzene | | | acetyl acetanilide | | 2- | acetyl acetanilide | | N-( | acetyl acetyl) aniline | | a- | acetyl-N-phenylacetamide | | | acetylacetanilide | | a- | acetylacetanilide | | alpha- | acetylacetanilide | | N-( | acetylacetyl)aniline | | | butanoic acid, 3-oxo-, amide, N-phenyl- | | b-keto | butyranilide | | beta-keto | butyranilide | | 3- | oxidanylidene-N-phenyl-butanamide | | N- | phenyl acetoacetamide | | 3-oxo-N- | phenyl-butyramide | | 3-oxo-N- | phenylbutanamid | | 3-oxo-N- | phenylbutanamide | | 1-( | phenylcarbamoyl)-2-propanone | | | AAA (acetoacetanilide) |
Articles:
| PubMed:Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products |
| PubMed:Multicomponent Reactions of Acetoacetanilide Derivatives with Aromatic Aldehydes and Cyanomethylene Reagents to Produce 4H-Pyran and 1,4-Dihydropyridine Derivatives with Antitumor Activities |
| PubMed:Cytotoxic and Antitumour Studies of Acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone and its Transition Metal Complexes |
| PubMed:Difluoroboron-acetoacetanilide |
| PubMed:Copper complexes bearing 2-aminobenzothiazole derivatives as potential antioxidant: Synthesis, characterization |
| PubMed:Synthesis and photoluminescent properties of lanthanides acetoacetanilide complexes |
| PubMed:Synthesis, characterization, and antifungal studies of transition metal complexes of omega-bromoacetoacetanilide isonicotinylhydrazone |
| PubMed:Claisen-Schmidt condensation: Synthesis of (1S,6R)/(1R,6S)-2-oxo-N,4,6-triarylcyclohex-3-enecarboxamide derivatives with different substituents in H(2) O/EtOH |
| PubMed:Determination of Very Low Level of Free Formaldehyde in Liquid Detergents and Cosmetic Products Using Photoluminescence Method |
| PubMed:Vibrational, NMR and quantum chemical investigations of acetoacetanilde, 2-chloroacetoacetanilide and 2-methylacetoacetanilide |
| PubMed:Trans-3,4-dideoxyglucone-3-ene (trans-3,4-DGE), a most reactive glucose degradation product in freshly heat sterilized glucose solutions |
| PubMed:Optical, elemental and structural analyses of acetoacetanilide single crystals for nonlinear optical applications |
| PubMed:Antifungal Activities of Copper(II) with Biosensitive Macrocyclic Schiff Base Ligands Derived from 4-Aminoantipyrine Derivatives |
| PubMed:Synthesis and antimicrobial activity of some new pyrazole, fused pyrazolo[3,4-d]-pyrimidine and pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine derivatives |
| PubMed:Chromium(III) selective membrane sensors based on Schiff bases as chelating ionophores |
| PubMed:Eco-efficient ultrasonic responsive synthesis of pyrimidines/pyridines |
| PubMed:Flow-injection spectrofluorometric determination of trace amounts of formaldehyde in water after derivatization with acetoacetanilide |
| PubMed:FeCl3?6H2O-catalyzed intermolecular-cascade cyclization of acetoacetanilide: aldehyde-tuned synthesis to valuable 2-pyridone analogues |
| PubMed:Simple fluorimetric method for quantification of sialic acids in glycoproteins |
| PubMed:Knorr cyclizations and distonic superelectrophiles |
| PubMed:Mononuclear Ru(III) Schiff base complexes: synthesis, spectral, redox, catalytic and biological activity studies |
| PubMed:Spectroscopic, and thermal studies of some new binuclear transition metal(II) complexes with hydrazone ligands containing acetoacetanilide and isoxazole |
| PubMed:Development of novel reagent for Hantzsch reaction for the determination of formaldehyde by spectrophotometry and fluorometry |
| PubMed:Reaction of Aliphatic Amines with Acetoacetanilide in the Presence of Zeolite Catalyst. Solvent-Free Synthesis of Symmetric N,N'-Dialkylureas |
| PubMed:Chemical ionization and high resolution electron impact mass spectra of 5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide and three of its metabolites |
| PubMed:Biomonitoring of arylamines: haemoglobin adducts of aniline derivatives |
| PubMed:Frost injury and heterogeneous ice nucleation in leaves of tuber-bearing solanum species : ice nucleation activity of external source of nucleants |
| PubMed:Antifungal Activities of Biorelevant Complexes of Copper(II) with Biosensitive Macrocyclic Ligands |
| PubMed:Synthesis, spectral, catalytic and antimicrobial studies of PPh3/AsPh3 complexes of Ru(II) with dibasic tridentate O, N, S donor ligands |
| PubMed:Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles |
| PubMed:Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas |
| PubMed:Antiviral compounds. 1. Structure-activity relationship of some antiviral enediones derived from aldehydo sugars |
| PubMed:Thin-layer chromatographic separation of some sulpha drugs using acetoacetanilide as a coupling agent |
| PubMed:Determination of acetaminophen and phenacetin in plasma by high-pressure liquid chromatography |
| PubMed:One-pot diastreoselective synthesis of highly functionalized cyclohexenones: 2-oxo-N,4,6-triarylcyclohex-3-enecarboxamides |
| PubMed:Selective electrochemical sensor for copper (II) ion based on chelating ionophores |
| PubMed:ArCH(OMe)?--a Pt(IV)-catalyst originator for diverse annulation catalysis |
| PubMed:A method for increasing the solubility of industrial azo pigments for (13) C and (1) H NMR spectra and the assignments of their (13) C and (1) H NMR peaks |
| PubMed:Comparative in vitro Cytotoxic Studies of Novel 8-(4'/2'-Methoxy/Unsubstituted phenylcarbamoyl)bicyclo[3.3.1]nonane Derivatives on Ehrlich Ascites Carcinoma Cell Line |
| PubMed:Metal-induced cyclization of thiosemicarbazones derived from beta-keto amides and beta-keto esters: open-chain and cyclized ligands in zinc(II) complexes |
| PubMed:Regiospecific ?-lactam ring-opening/recyclization reactions of N-aryl-3-spirocyclic-?-lactams catalyzed by a Lewis-Br?nsted acids combined superacid catalyst system: a new entry to 3-spirocyclicq |
| PubMed:Syntheses of 1,3-imidazolin-2-ones and 1,3-imidazolin-2-thiones from new building blocks, gamma-aminoacetoacetanilides |
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3D/inchi