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folic acid
L-pteroylglutamic acid

Supplier Sponsors

Name:(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
CAS Number: 59-30-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-419-0
FDA UNII:935E97BOY8
Nikkaji Web:J1.392G
Beilstein Number:100781
MDL:MFCD00079305
XlogP3-AA:-1.10 (est)
Molecular Weight:441.40463000
Formula:C19 H19 N7 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FR DOC # 2012-14263 Gruma Corporation, Spina Bifida Association, March of Dimes Foundation, American Academy of Pediatrics, Royal DSM N.V., and National Council of La Raza; Filing of Food Additive Petition View - petition PDF
FR DOC # 2012-17432 Gruma Corporation, Spina Bifida Association, March of Dimes Foundation, American Academy of Pediatrics, Royal DSM N.V., and National Council of La Raza; Filing of Food Additive Petition; Correction View - petition PDF
FDA Mainterm (SATF):59-30-3 ; FOLIC ACID
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart E--Specific Requirements for Health Claims
Sec. 101.79 Health claims: Folate and neural tube defects.


FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.


FDA PART 107 -- INFANT FORMULA
Subpart D--Nutrient Requirements
Sec. 107.100 Nutrient specifications.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.165 Enriched flour.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.185 Enriched self-rising flour.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.260 Enriched corn meals.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.305 Enriched farina.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.350 Enriched rice.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.115 Enriched macaroni products.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.122 Enriched nonfat milk macaroni products.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.155 Enriched noodle products.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart D--Special Dietary and Nutritional Additives
Sec. 172.345 Folic acid (folacin).


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.896 Dried yeasts.
 
Physical Properties:
Appearance:yellow to yellowish orange crystals (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 250.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.990 (est)
Soluble in:
 water, 1.6 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
AIDP
Folic Acid 10%10% min
AIDP
Folic Acid 97% min
American International Chemical, LLC.
Folic Acid
Atlantic Chemicals
Folic Acid (Vitamin B9)
BOC Sciences
For experimental / research use only.
Folic acid ≥96%
Odor: characteristic
Use: Folic acid is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, and it also acts as a cofactor in biological reactions involving folate. The combined use of enalapril and Folic acid, compared with enalapril alone, Hematopoietic vitamin
Charkit Chemical
FOLIC ACID
ECSA Chemicals
FOLIC ACID
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ExtraSynthese
For experimental / research use only.
Folic Acid
Farbest-Tallman Foods
Folic Acid USP
Flavor: bland
It is used in food and dietary supplement applications including those targeting prenatal health.
Foodchem International
Folic Acid
Glentham Life Sciences
Folic acid, USP grade
Glentham Life Sciences
Folic acid
Jiangyin Healthway
Folic Acid
New functional food ingredients
Maypro Industries
Folic Acid
Penta International
FOLIC ACID FOOD GRADE
Penta International
FOLIC ACID USP
Penta International
FOLIC ACID USP/EP GRADE
Prinova
Folic Acid BP,USP
Shaanxi Y-Herb Biotechnology
USP Grade Folic Acid Monomer Powder Pharmaceutical Food Grade Vitamin B9 Powder
Shiva Chemicals and Pharmaceuticals
Folic Acid
Sigma-Aldrich: Sigma
For experimental / research use only.
Folic Acid ≥97%
SRS Aromatics
FOLIC ACID USP 38
Tianjin Talent Chemical
VB9 (Folic Acid)
United International
Folic Acid
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 500 mg/kg
Drugs in Japan Vol. -, Pg. 1409, 1995.

intravenous-rabbit LD50 410 mg/kg
Drugs in Japan Vol. -, Pg. 1409, 1995.

oral-mouse LD50 10000 mg/kg
Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.

intravenous-mouse LD50 282 mg/kg
Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.

intraperitoneal-mouse LD50 85 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Experientia. Vol. 41, Pg. 72, 1985.

intravenous-guinea pig LD50 120 mg/kg
Drugs in Japan Vol. -, Pg. 1409, 1995.

Dermal Toxicity:
subcutaneous-mouse LDLo 200 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN
Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 544, 1949.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for folic acid usage levels up to:
 not for fragrance use.
 
Recommendation for folic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the safety and efficacy of folic acid as a feed additive for all animal species
View page or View pdf

Scientific Opinion on the substantiation of a health claim related to increasing maternal folate status by supplemental folate intake and reduced risk of neural tube defects pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for folate
View page or View pdf

Scientific Opinion on Dietary Reference Values for folate
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):59-30-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6037
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Chemidplus:0000059303
EPA/NOAA CAMEO:hazardous materials
 
References:
 (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:59-30-3
Pubchem (cid):6037
Pubchem (sid):134972291
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C00504
HMDB (The Human Metabolome Database):HMDB00121
FooDB:FDB014504
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•5 mg (base) per ml (rx) [folvite (benzyl alcohol 1.5 %)]; 10 mg per ml (rx) •folic acid (folvite) is marketed as oral tablets containing 0.4, 0.8, and 1 mg and as an aqueous solution for injection. tablets of folic acid contain either 0.1, 0.4, 0.8, or 1 mg of pteroylglutamic acid, as an aqueous solution for injection, and in combination with other vitamins and minerals •injectable solutions are prepared by dissolving folic acid in normal sodium bicarbonate solution (which should be sterilized by filtration) or by preparing solutions of the sodium or methylglucamine salt. •lexpec folic acid. syrup containing folic acid 2.5 mg in each 5 ml (recommended diluent, sorbitol solution or sorbitol solution and water, equal parts). •10% feed grade, usp
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 biological additives
 
Occurrence (nature, food, other):note
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 wheat seed
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Synonyms:
N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-laevo-glutamic acid
N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)-L-glutamic acid
(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
(2S)-2-{[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]amino}pentanedioic acid
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
 apo-folic
 dosfolat B activ
 folacin
 folate
L-glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-
L-glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
L-glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
 glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-
 glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
L-glutamic acid, N-[4-[[(1,2-dihydro-4-hydroxy-2-imino-6-pteridinyl)methyl]amino]benzoyl]-
L-glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
L-glutamic acid, N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-
L-glutamic acid, N-[4-[[(2-amino-4,8-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
 glutamic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, l-
 glutamic acid, pteroyl-, L-
 novo-folacid
 pteroyl glutamic acid
 pteroyl-L-glutamic acid
N-pteroyl-L-glutamic acid
 pteroyl-L-monoglutamic acid
L-pteroylglutamic acid
 vitamin M
 

Articles:

Info:Folic Acid
PubMed:Comparative studies on storage stability of ferrous iron in whole wheat flour and flat bread (naan).
J-Stage:Folic Acid Fortification Ameliorates Hyperhomocysteinemia Caused by a Vitamin B6-Deficient Diet Supplemented with L-Methionine
PubMed:Characteristics of reduced fat milks as influenced by the incorporation of folic acid.
PubMed:Multivitamin production in Lactococcus lactis using metabolic engineering.
PubMed:Nutritional status of infants and young children and characteristics of their diets.
PubMed:[Chemical and sensory characterization of cakes enriched with dietary fiber and micronutrient for the elderly].
PubMed:II. Glutamine and glutamate.
PubMed:[Optimization of a spaghetti formula enriched with dietary fiber and micronutrients for elderly people].
PubMed:[Fortification and evaluation of the nixtamal tortillas].
PubMed:Whole grains, refined grains and fortified refined grains: What's the difference?
PubMed:[Development and optimization of an isotonic sports drink].
PubMed:B-complex vitamins in cultured and acidified yogurt.
 
Notes:
a member of the vitamin b family that stimulates the hematopoietic system. it is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. Dietary supplement Folic acid (also known as vitamin B9, vitamin Bc or folacin) and folate (the naturally occurring form), as well as pteroyl-L-glutamic acid, pteroyl-L-glutamate, and pteroylmonoglutamic acid are forms of the water-soluble vitamin B9. [Wikipedia]
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