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ferric pyrophosphate
pyrophosphoric acid iron(3+) salt (3:4)

Supplier Sponsors

CAS Number: 10058-44-3Picture of molecule3D/inchi
Other(deleted CASRN):87059-16-3
ECHA EINECS - REACH Pre-Reg:233-190-0
FDA UNII: QK8899250F
MDL:MFCD00016091
Molecular Weight:745.20577200
Formula:Fe4 O21 P6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
184.1304 Ferric pyrophosphate View - review
FDA Mainterm (SATF):10058-44-3 ; FERRIC PYROPHOSPHATE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1304 Ferric pyrophosphate.


FDA PART 582 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 582.80 Trace minerals added to animal feeds.
 
Physical Properties:
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -3.420 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American Elements
Iron(III) Pyrophosphate 99%
Odor: characteristic
Use: Iron(III) Pyrophosphate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Ferric Pyrophosphate
Glentham Life Sciences
Iron(III) pyrophosphate hydrate
Penta International
FERRIC PYROPHOSPHATE
Qingdao Dacon Trading
Ferric Pyrophosphate
Santa Cruz Biotechnology
For experimental / research use only.
Iron(III) pyrophosphate tribasic hydrate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Iron(III) pyrophosphate
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for ferric pyrophosphate usage levels up to:
 not for fragrance use.
 
Recommendation for ferric pyrophosphate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Peer review of the pesticide risk assessment of the active substance ferric pyrophosphate
View page or View pdf

ClinicalTrials.gov:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):10058-44-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24877
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
iron(3+); phosphonato phosphate
Chemidplus:0010058443
 
References:
 iron(3+); phosphonato phosphate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:10058-44-3
Pubchem (cid):24877
Pubchem (sid):134990944
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB014067
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
24% iron minimum. not to be confused with ferric pyrophosphate, soluble. ferric pyrophosphate, soluble is a combination of ferric pyrophosphate & sodium citrate 11% iron.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 diphosphoric acid iron(III) salt
 ferric pyrophosphate FCC
 ferricpyrophosphate
 iron (III) pyrophosphate
 iron pyrophosphate
 iron(3+) diphosphate (4:3)
 iron(3+) pyrophosphate
 iron(3+); phosphonato phosphate
 iron(III) pyrophosphate
 pyrophosphoric acid iron(3+) salt (3:4)
 sunactive Fe
 tetrairon tris(pyrophosphate)
 

Articles:

PubMed:Colloidal iron(III) pyrophosphate particles.
PubMed:[Liposomial iron: a new proposal for the treatment of anaemia in chronic kidney disease].
PubMed:Rice fortified with iron given weekly increases hemoglobin levels and reduces anemia in infants: a community intervention trial.
PubMed:Iron bioavailability in Wistar rats fed with fortified rice by Ultra Rice technology with or without addition of yacon flour (Smallanthus sonchifolius).
PubMed:Microporation and 'iron'tophoresis for treating iron deficiency anemia.
PubMed:Repeptization by dissolution in a colloidal system of iron(III) pyrophosphate.
PubMed:Ferrous ammonium phosphate (FeNH₄PO₄) as a new food fortificant: iron bioavailability compared to ferrous sulfate and ferric pyrophosphate from an instant milk drink.
PubMed:[Effect of iron supplementation on iron deficiency anemia of childbearing age women in Shanghai].
PubMed:An ammonium iron(II) pyrophosphate, (NH(4))(2)[Fe(3)(P(2)O(7))(2)(H(2)O)(2)], with a layered structure.
PubMed:Micronized ferric pyrophosphate supplied through extruded rice kernels improves body iron stores in children: a double-blind, randomized, placebo-controlled midday meal feeding trial in Indian schoolchildren.
PubMed:Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women.
PubMed:Iron deficiency up-regulates iron absorption from ferrous sulphate but not ferric pyrophosphate and consequently food fortification with ferrous sulphate has relatively greater efficacy in iron-deficient individuals.
PubMed:Hemoglobin regeneration efficiency in anemic rats: effects on bone mineral composition and biomechanical properties.
PubMed:Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate.
PubMed:New lithium iron pyrophosphate as 3.5 V class cathode material for lithium ion battery.
PubMed:[Polish Gynecological Society Experts' position on the use of Pregnamedc zelazo in gynecology and obstetrics].
PubMed:Difructose anhydride III enhances bioavailability of water-insoluble iron in anemic Vietnamese women.
PubMed:Constant voltage 'Iron'tophoresis.
PubMed:Iron-fortified rice is as efficacious as supplemental iron drops in infants and young children.
PubMed:Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin.
PubMed:Relative bioavailability of iron and folic acid from a new powdered supplement compared to a traditional tablet in pregnant women.
PubMed:Albumin microspheres for oral delivery of iron.
PubMed:Comparing soluble ferric pyrophosphate to common iron salts and chelates as sources of bioavailable iron in a Caco-2 cell culture model.
PubMed:Regular consumption of a complementary food fortified with ascorbic acid and ferrous fumarate or ferric pyrophosphate is as useful as ferrous sulfate in maintaining hemoglobin concentrations >105 g/L in young Bangladeshi children.
PubMed:Relative bioavailability of micronized, dispersible ferric pyrophosphate added to an apple juice drink.
PubMed:Irontophoresis: transdermal delivery of iron by iontophoresis.
PubMed:Dual fortification of salt with iodine and iron: a randomized, double-blind, controlled trial of micronized ferric pyrophosphate and encapsulated ferrous fumarate in southern India.
PubMed:Does ascorbic acid supplementation affect iron bioavailability in rats fed micronized dispersible ferric pyrophosphate fortified fruit juice?
PubMed:Stabilized-solubilized ferric pyrophosphate as a new iron source for food fortification. Bioavailability studies by means of the prophylactic-preventive method in rats.
PubMed:Efficacy of iron-fortified rice in reducing anemia among schoolchildren in the Philippines.
PubMed:Iron absorption from meat pate fortified with ferric pyrophosphate in iron-deficient women.
PubMed:Efficacy of iron-fortified Ultra Rice in improving the iron status of women in Mexico.
PubMed:Caseinophosphopeptide-bound iron: protective effect against gut peroxidation.
PubMed:Functional analysis of the multi-copper oxidase from Legionella pneumophila.
PubMed:The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocins.
PubMed:A comparative study of iron bioavailability from cocoa supplemented with ferric pyrophosphate or ferrous fumarate in rats.
PubMed:Low dose 'Sprinkles'-- an innovative approach to treat iron deficiency anemia in infants and young children.
PubMed:Synthesis, characterization, and bioavailability in rats of ferric phosphate nanoparticles.
PubMed:Improved iron bioavailability in an oat-based beverage: the combined effect of citric acid addition, dephytinization and iron supplementation.
PubMed:Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal.
PubMed:An effective and low-cost culture medium for isolation and growth of Xylella fastidiosa from citrus and coffee plants.
PubMed:Extruded rice fortified with micronized ground ferric pyrophosphate reduces iron deficiency in Indian schoolchildren: a double-blind randomized controlled trial.
PubMed:Multi-micronutrient Sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: a randomized clinical trial.
PubMed:Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire.
PubMed:Iron fortification reduces blood lead levels in children in Bangalore, India.
PubMed:FTIR features of lithium-iron phosphates as electrode materials for rechargeable lithium batteries.
PubMed:Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans.
PubMed:In vitro evaluation of iron solubility and dialyzability of various iron fortificants and of iron-fortified milk products targeted for infants and toddlers.
PubMed:In vitro iron availability from iron-fortified whole-grain wheat flour.
PubMed:Effect of ascorbic acid and particle size on iron absorption from ferric pyrophosphate in adult women.
PubMed:Particle size reduction and encapsulation affect the bioavailability of ferric pyrophosphate in rats.
PubMed:Triple fortification of salt with microcapsules of iodine, iron, and vitamin A.
PubMed:Dual fortification of salt with iodine and micronized ferric pyrophosphate: a randomized, double-blind, controlled trial.
PubMed:Iron absorption and bioavailability in rats of micronized dispersible ferric pyrophosphate.
PubMed:A micronised, dispersible ferric pyrophosphate with high relative bioavailability in man.
PubMed:Gamma-proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media.
PubMed:Characterization of Fe(III) reduction by chlororespiring Anaeromyxobacter dehalogenans.
PubMed:Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt.
PubMed:An evaluation of EDTA compounds for iron fortification of cereal-based foods.
PubMed:Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration?
PubMed:Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate.
PubMed:Effects of ascorbic acid on interactions between ciprofloxacin and ferrous sulphate, sodium ferrous citrate or ferric pyrophosphate, in mice.
PubMed:Identification of the syntrophic partners in a coculture coupling anaerobic methanol oxidation to Fe(III) reduction.
PubMed:Characterization of a flavocytochrome that is induced during the anaerobic respiration of Fe3+ by Shewanella frigidimarina NCIMB400.
PubMed:Dialysate iron therapy: infusion of soluble ferric pyrophosphate via the dialysate during hemodialysis.
PubMed:Continuous axenic cultivation of Pneumocystis carinii.
PubMed:The antioxidant action of 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-alpha]pyra z in-3-one (MCLA), a chemiluminescence probe to detect superoxide anions.
PubMed:Geovibrio ferrireducens, a phylogenetically distinct dissimilatory Fe(III)-reducing bacterium.
PubMed:Effects of fructooligosaccharides on the absorption of iron, calcium and magnesium in iron-deficient anemic rats.
PubMed:Iron acquisition by Cryptococcus neoformans.
PubMed:A microsomal membrane component associated with iron reduction in NADPH-supported lipid peroxidation.
PubMed:Investigations of culture and properties of Afipia spp.
PubMed:Effect of recombinant human erythropoietin on anaemia after gastrectomy: a pilot study.
PubMed:Cholate solubilization of liver microsomal membrane components which promote NADPH-supported lipid peroxidation.
PubMed:Effects of calcium on hepatocyte iron uptake from transferrin, iron-pyrophosphate and iron-ascorbate.
PubMed:Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila.
PubMed:Ferrous fumarate fortification of a chocolate drink powder.
PubMed:Interactions between infections, malnutrition and iron nutritional status in Pakistani infants. A longitudinal study.
PubMed:Activated polymorphonuclear leukocytes inhibit phosphatidylcholine synthesis in cultured type II alveolar cells.
PubMed:Paramagnetic pyrophosphate. Preliminary studies on magnetic resonance contrast enhancement of acute myocardial infarction.
PubMed:Iron fortification of infant cereals: a proposal for the use of ferrous fumarate or ferrous succinate.
PubMed:Kinetics of pyrophosphate induced iron release from diferric ovotransferrin.
PubMed:Oxidation of esterified arachidonate by rat liver microsomes.
PubMed:Factors affecting growth of Legionella pneumophila in liquid media.
PubMed:The exchange of Fe3+ between pyrophosphate and transferrin. Probing the nature of an intermediate complex with stopped flow kinetics, rapid multimixing, and electron paramagnetic resonance spectroscopy.
PubMed:Inhibition of microsomal lipid peroxidation by naphthoquinones: structure-activity relationships and possible mechanisms of action.
PubMed:[Cultivation characteristics of Legionella pneumophila in a liquid medium].
PubMed:Transferrin as a donor of iron to mitochondria. Effect of pyrophosphate and relationship to mitochondrial metabolism and heme synthesis.
PubMed:Pyrophosphate as a ligand for delivery of iron to isolated rat-liver mitochondria.
PubMed:Isolation of Legionella pneumophila serogroup 1 from blood with nonsupplemented blood culture bottles.
PubMed:A simple disc technique for the presumptive identification of Legionella pneumophila.
PubMed:[Practical problems raised by antibiotic minimal inhibitory concentration determination in Legionella species (author's transl)].
PubMed:[A growth media of genus Legionella in containing saccharated ferric oxide (Fesin) replacing soluble ferric pyrophosphate (author's transl)].
PubMed:Studies on the mechanism of pyrophosphate-mediated uptake of iron from transferrin by isolated rat-liver mitochondria.
PubMed:Chemically defined medium for Legionella pneumophila growth.
PubMed:Growth, survival, and resistance of the Legionnaires' disease bacterium.
PubMed:Bioavailability of zinc in infant cereals.
PubMed:Primary isolation media for Legionnaires disease bacterium.
PubMed:Semiautomated fluorometric analysis of riboflavin in nutrient premixes containing reduced iron.
PubMed:Inhibition of nadph-driven microsomal lipid peroxidation by cytosol factor(s). Effect of a fat-free, high carbohydrate diet.
PubMed:Biological availability of iron supplements for rats, chicks and humans.
PubMed:The absorption of iron as supplements in infant cereal and infant formulas.
 
Notes:
Nutrient supplement used in bread fortification and infant formulas
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