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Category:food contact closures with sealing gaskets for food containers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to pale yellow crystalline powder (est) |
| Assay: | 99.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 79.00 to 81.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 221.00 to 222.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 1.000000 mmHg @ 65.00 °C. |
| Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. )
|
| logP (o/w): | -1.260 |
| Soluble in: |
| | alcohol | | | water, 1e+006 mg/L @ 25 °C (est) | | | water, 2.25E+06 mg/L @ 25 °C (exp) |
| Similar Items:note |
| acetamide MEA |
Organoleptic Properties:
| Odor Description:bland |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 36/37 - Irritating to eyes and respiratory system.
R 40 - Possible risks of irreversable effects.
S 02 - Keep out of the reach of children.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 7000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
intravenous-rat LD50 12500 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
intraperitoneal-rat LD50 10300 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
intravenous-rabbit LD50 7500 mg/kg
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
oral-mouse LD50 12900 mg/kg
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
intravenous-mouse LD50 10000 mg/kg
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
intraperitoneal-mouse LD50 1000 mg/kg
JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
intravenous-chicken LDLo 33410 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
intravenous-rat LD50 12500 mg/kg
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
oral-rat LD50 7000 mg/kg
Journal of Reproduction and Fertility. Vol. 4, Pg. 219, 1962.
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| Dermal Toxicity: |
subcutaneous-rat LD50 10000 mg/kg
AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
CARDIAC: CHANGE IN RATE
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
subcutaneous-mouse LD50 8300 mg/kg
AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
CARDIAC: CHANGE IN RATE
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | food contact closures with sealing gaskets for food containers |
| Recommendation for acetamide usage levels up to: | | | not for fragrance use.
|
| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 22 |
| Click here to view publication 22 |
| | average usual ppm | average maximum ppm |
| baked goods: | 1.00000 | 5.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | 0.20000 | 1.00000 |
| cheese: | 0.40000 | 2.00000 |
| chewing gum: | - | - |
| condiments / relishes: | 0.10000 | 0.50000 |
| confectionery froastings: | 1.00000 | 5.00000 |
| egg products: | - | - |
| fats / oils: | 0.10000 | 0.50000 |
| fish products: | 0.20000 | 1.00000 |
| frozen dairy: | 0.40000 | 2.00000 |
| fruit ices: | 0.40000 | 2.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | 0.20000 | 1.00000 |
| milk products: | 0.40000 | 2.00000 |
| nut products: | - | - |
| other grains: | 0.20000 | 1.00000 |
| poultry: | 0.20000 | 1.00000 |
| processed fruits: | 0.40000 | 2.00000 |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | 0.10000 | 0.50000 |
| snack foods: | 1.00000 | 5.00000 |
| soft candy: | - | - |
| soups: | 0.10000 | 0.50000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetic acid amide | | | ethanamide | | | formamide, methyl- | | | methane carboxamide | | | methanimidic acid, methyl- | | | methylcarbylamine | | mono | methylformamide | | | methylimidoformic acid |
Articles:
| PubMed:Pellet cryopreservation for chicken semen: effects of sperm working concentration, cryoprotectant concentration, and equilibration time during in vitro processing. |
| PubMed:The postprandial plasma rye fingerprint includes benzoxazinoid-derived phenylacetamide sulfates. |
| PubMed:Inhibition of β-N-acetylglucosaminidase by acetamide affects sperm motility and fertilization success of rainbow trout (Oncorhynchus mykiss) and Siberian sturgeon (Acipenser baerii). |
| PubMed:The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying. |
| PubMed:Ammoxidation of lignocellulosic materials: formation of nonheterocyclic nitrogenous compounds from monosaccharides. |
| PubMed:Can the unauthorised use of ceftiofur be detected in poultry? |
| PubMed:Synthesis and anticonvulsant and antidepressant activity of 2-(5-bromo-2,3-dioxoindolin)-N-substituted phenylacetamide derivatives. |
| PubMed:Comparative analysis of flagellin glycans among pathovars of phytopathogenic Pseudomonas syringae. |
| PubMed:Hydroxylated phenylacetamides derived from bioactive benzoxazinoids are bioavailable in humans after habitual consumption of whole grain sourdough rye bread. |
| PubMed:Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications. |
| PubMed:SEPALLATA1/2-suppressed mature apples have low ethylene, high auxin and reduced transcription of ripening-related genes. |
| PubMed:Biodegradation of butachlor by Rhodococcus sp. strain B1 and purification of its hydrolase (ChlH) responsible for N-dealkylation of chloroacetamide herbicides. |
| PubMed:Inclusion of 1-naphthylacetic acid and 2-(1-naphthyl)acetamide into three typical multiresidue methods for LC/MS/MS analysis of tomatoes and zucchini. |
| PubMed:New nitrogen-containing bromophenols from the marine red alga Rhodomela confervoides and their radical scavenging activity. |
| PubMed:Isolation, identification and characterization of human intestinal bacteria with the ability to utilize chloramphenicol as the sole source of carbon and energy. |
| PubMed:Radiation dosimetry and biodistribution of the TSPO ligand 11C-DPA-713 in humans. |
| PubMed:Forced degradation study of thiocolchicoside: characterization of its degradation products. |
| PubMed:Assessment of liquid chromatography-tandem mass spectrometry approaches for the analysis of ceftiofur metabolites in poultry muscle. |
| PubMed:Activity of meadowfoam (Limnanthes alba) seed meal glucolimnanthin degradation products against soilborne pathogens. |
| PubMed:Discriminating multiple impacts of biogas residues amendment in selectively decontaminating chloroacetanilide herbicides. |
| PubMed:Biodegradation of chloroacetamide herbicides by Paracoccus sp. FLY-8 in vitro. |
| PubMed:Fate and efficacy of metolachlor granular and emulsifiable concentrate formulations in a conservation tillage system. |
| PubMed:T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine. |
| PubMed:A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity. |
| PubMed:Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. |
| PubMed:Identification of Pseudomonas aeruginosa in water-bottling plants on the basis of procedures included in ISO 16266:2006. |
| PubMed:Reduction in metolachlor and degradate concentrations in shallow groundwater through cover crop use. |
| PubMed:Reactivity of 1-deoxy-D-erythro-hexo-2,3-diulose: a key intermediate in the maillard chemistry of hexoses. |
| PubMed:2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. |
| PubMed:Runoff and leaching of metolachlor from Mississippi River alluvial soil during seasons of average and below-average rainfall. |
| PubMed:2-Chloro-N,N-diphenyl-acetamide. |
| PubMed:Characterization of metabolites of fungicidal cymoxanil in a sensitive strain of Botrytis cinerea. |
| PubMed:A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state. |
| PubMed:The conversion of chicken manure to bio-oil by fast pyrolysis. III. Analyses of chicken manure, bio-oils and char by Py-FIMS and Py-FDMS. |
| PubMed:Suitability of two laboratory testing methods to evaluate the side effects of pesticides on Typhlodromus pyri Scheuten (Acari: Phytoseiidae). |
| PubMed:Synthesis and antimicrobial activity of some derivatives of (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide. |
| PubMed:Detection of Pseudomonas aeruginosa in water samples using a novel synthetic medium and impedimetric technology. |
| PubMed:Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. |
| PubMed:Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats. |
| PubMed:Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp. |
| PubMed:One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition. |
| PubMed:Felinine stability in the presence of selected urine compounds. |
| PubMed:Degradation of chloroacetanilide herbicides by anodic fenton treatment. |
| PubMed:QSAR models for Daphnia magna toxicity prediction of benzoxazinone allelochemicals and their transformation products. |
| PubMed:Joint action of benzoxazinone derivatives and phenolic acids. |
| PubMed:Degradation of alachlor in natural and sludge-amended soils, studied by gas and liquid chromatography coupled to mass spectrometry (GC-MS and HPLC-MS). |
| PubMed:Synthesis of new benzoxazinone derivatives as neuropeptide Y5 antagonists for the treatment of obesity. |
| PubMed:Effect of processing on Celecoxib and its solvates. |
| PubMed:[Modafinil and fatigue in multiple sclerosis]. |
| PubMed:Application of micellar electrokinetic capillary chromatography to the analysis of uncharged pesticides of environmental impact. |
| PubMed:Kinetic evidence related to substrate-assisted catalysis of family 18 chitinases. |
| PubMed:Kinetics and mechanism of the nucleophilic displacement reactions of chloroacetanilide herbicides: investigation of alpha-substituent effects. |
| PubMed:Kinetics and mechanism of cymoxanil degradation in buffer solutions. |
| PubMed:Reaction mechanism of chitobiose phosphorylase from Vibrio proteolyticus: identification of family 36 glycosyltransferase in Vibrio. |
| PubMed:Indole derivatives produced by the fungus Colletotrichum acutatum causing lime anthracnose and postbloom fruit drop of citrus. |
| PubMed:Multilaboratory trial for determination of ceftiofur residues in bovine and swine kidney and muscle, and bovine milk. |
| PubMed:Determination of triazine and chloroacetanilide herbicides in soils by microwave-assisted extraction (MAE) coupled to gas chromatographic analysis with either GC-NPD or GC-MS. |
| PubMed:Analysis and detection of the herbicides dimethenamid and flufenacet and their sulfonic and oxanilic acid degradates in natural water. |
| PubMed:Runoff and drainage losses of atrazine, metribuzin, and metolachlor in three water management systems. |
| PubMed:NMR and MS analysis of decomposition compounds produced from N-acetyl-L-glutamine at low pH. |
| PubMed:Comparison of enzyme-linked immunosorbent assay and gas chromatography procedures for the detection of cyanazine and metolachlor in surface water samples. |
| PubMed:Tillage, intercrop, and controlled drainage-subirrigation influence atrazine, metribuzin, and metolachlor loss. |
| PubMed:Development of a gas chromatographic method for fungicide cymoxanil analysis in dried hops. |
| PubMed:Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling. |
| PubMed:Structural influences in relative sorptivity of chloroacetanilide herbicides on soil. |
| PubMed:Pressurized fluid extraction for quantitative recovery of chloroacetanilide and nitrogen heterocyclic herbicides in soil. |
| PubMed:Photodegradation of metolachlor: isolation, identification, and quantification of monochloroacetic acid. |
| PubMed:Methylene group modifications of the N-(Isothiazol-5-yl)phenylacetamides. Synthesis and insecticidal activity. |
| PubMed:Identification of the major urinary and fecal metabolites of 3,5-dinitrobenzamide in chickens and rats. |
| PubMed:A novel, selective synthetic acetamide containing culture medium for isolating Pseudomonas aeruginosa from milk. |
| PubMed:Metabolism of metolachlor by the fungus Cunninghamella elegans. |
| PubMed:Effects of anticonvulsants in a novel operant learning paradigm in rats: comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents. |
| PubMed:Determination of ephedrine, pseudoephedrine, and norephedrine in mixtures (bulk and dosage forms) by proton nuclear magnetic resonance spectroscopy. |
| PubMed:Friedländer synthesis of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. |
| PubMed:Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp. |
| PubMed:Oncogenicity studies of the cognition-enhancing agent nefiracetam in mice and rats. |
| PubMed:Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. |
| PubMed:Reproductive toxicity studies of the new cognition-enhancing agent nefiracetam in rats and rabbits. |
| PubMed:Thirteen-week oral toxicity study of the new cognition-enhancing agent nefiracetam in dogs. |
| PubMed:Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia. |
| PubMed:Enhancement of the prophagic but not of the antidipsogenic effect of U-50, 488H after chronic amphetamine. |
| PubMed:An analytical study of antibacterial residues in meat: the simultaneous determination of 23 antibiotics and 13 drugs using gas chromatography. |
| PubMed:Single- and multiple-dose pharmacokinetics of nefiracetam, a new nootropic agent, in healthy volunteers. |
| PubMed:Metabolism of acrylonitrile by Klebsiella pneumoniae. |
| PubMed:Rapid and uniform electromagnetic heating of aqueous cryoprotectant solutions from cryogenic temperatures. |
| PubMed:A synthetic, selective culture medium for Pseudomonas aeruginosa. |
| PubMed:Inhibition of spontaneous growth and induced differentiation of murine erythroleukaemia cells by paraquat and atrazine. |
| PubMed:Orally administered kappa but not mu opiate agonists enhance gastric emptying of a solid canned food meal in dogs. |
| PubMed:Discriminative stimulus properties of physostigmine in rats. |
| PubMed:The kappa agonists PD117302 and U50488 produce a biphasic effect on 24 hour food intake in the rat. |
| PubMed:Simultaneous gas chromatographic determination of carboxylic acids in soft drinks and jams. |
| PubMed:Pharmacokinetics of acetohydroxamic acid in patients with staghorn renal calculi. |
| PubMed:Metabolism of AC 206,784 herbicide [2-chloro-N-(2,3-dimethylphenyl)-N-(1-methylethyl)acetamide] in soybean plants. |
| PubMed:Residues of the plant growth regulator mefluidide [N-[2,4]dimethy-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide] in the milk and tissues of lactating dairy cows: a 28-day feeding study. |
| PubMed:Fate of the plant growth regulator mefluidide [N-[2,4-dimethyl-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide] in a cow and sheep. |
| PubMed:2-Cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide, a new fungicide. |
| PubMed:Gas-liquid chromatographic/mass spectrometric screening method for T-2 toxin in milk. |
| PubMed:Excretion and metabolism of 3,4,5-tribromo-N,N,alpha-trimethyl-1H-pyrazole-1-acetamide in the rat. |
| PubMed:Gas-liquid chromatographic determination of vinyl chloride in vinyl chloride polymers, food-simulating solvents, and other samples. |
| PubMed:Gas-liquid chromatographic determination of diethylstilbestrol in molasses-based liquid feed supplements. |
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Acetamide (or acetic acid amide or ethanamide), CH3CONH2, the amide of acetic acid, is a white crystalline solid in pure form. It is produced by dehydrating ammonium acetate:
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3D/inchi