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Category:indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 43.34 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 457 mg/kg
BEHAVIORAL: TREMOR
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
National Technical Information Service. Vol. OTS0555324
oral-rat LD50 430 mg/kg
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: ATAXIA
American Industrial Hygiene Association Journal. Vol. 41, Pg. 576, 1980.
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| Dermal Toxicity: |
skin-rabbit LD50 4300 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 81, Pg. 348, 1985.
skin-rat LD50 7000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 81, Pg. 348, 1985.
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| Inhalation Toxicity: |
inhalation-rat LC50 980 mg/m3/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE
Food and Chemical Toxicology. Vol. 24, Pg. 1325, 1986.
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Safety in Use Information:
| Category: | | indirect food additives: adhesives and components of coatings |
| Recommendation for ammonium perfluorooctanoate usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for ammonium perfluorooctanoate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Outcome of a public consultation on the draft risk assessment of perfluoroalkyl substances in food
View page or View pdf
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Risk to human health related to the presence of perfluoroalkyl substances in food
View page or View pdf
|
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):3825-26-1 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :2776282 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| azanium;2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoate |
| Chemidplus:0003825261 |
| RTECS:RH0782000 for cas# 3825-26-1 |
References:
| | azanium;2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 3825-26-1 |
| Pubchem (cid): | 2776282 |
| Pubchem (sid): | 135020328 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | azanium;2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoate | | per | fluorooctanoic acid, ammonium salt | | | octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-, ammonium salt (1:1) | | | pentadecafluoro-1-octanoic acid, ammonium salt |
Articles:
| PubMed:Coupling sweeping-micellar electrokinetic chromatography with tandem mass spectrometry for the therapeutic monitoring of benzimidazoles in animal urine by dilute and shoot. |
| PubMed:Enantioselective capillary electrophoresis-mass spectrometry of amino acids in cerebrospinal fluid using a chiral derivatizing agent and volatile surfactant. |
| PubMed:A micellar electrokinetic chromatography-mass spectrometry approach using in-capillary diastereomeric derivatization for fully automatized chiral analysis of amino acids. |
| PubMed:Vortex-assisted surfactant-enhanced emulsification liquid-liquid microextraction for the determination of carbamates in juices by micellar electrokinetic chromatography tandem mass spectrometry. |
| PubMed:New pressure-assisted sweeping on-line preconcentration for highly polar environmentally relevant nitrosamines: Part 2. Cationic and anionic surfactants with zero-flow capillaries. |
| PubMed:Evaluation of the combination of a dispersive liquid-liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt. |
| PubMed:Mortality and cancer incidence in ammonium perfluorooctanoate production workers. |
| PubMed:MEKC-MS/MS method using a volatile surfactant for the simultaneous determination of 12 synthetic cannabinoids. |
| PubMed:Intensification of sonochemical degradation of ammonium perfluorooctanoate by persulfate oxidant. |
| PubMed:Micellar electrokinetic chromatography-electrospray ionization mass spectrometry employing a volatile surfactant for the analysis of amino acids in human urine. |
| PubMed:Perfluorinated compounds in soils from Liaodong Bay with concentrated fluorine industry parks in China. |
| PubMed:Dispersive liquid-liquid microextraction using a low density extraction solvent for the determination of 17 N-methylcarbamates by micellar electrokinetic chromatography-electrospray-mass spectrometry employing a volatile surfactant. |
| PubMed:Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats. |
| PubMed:Exposure assessment of tetrafluoroethylene and ammonium perfluorooctanoate 1951-2002. |
| PubMed:Perfluorooctanoic acid and ammonium perfluorooctanoate: volatile surfactants for proteome analysis? |
| PubMed:Toxicological evaluation of ammonium perfluorobutyrate in rats: twenty-eight-day and ninety-day oral gavage studies. |
| PubMed:Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα. |
| PubMed:Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice. |
| PubMed:Toxicological evaluation of ammonium 4,8-dioxa-3H-perfluorononanoate, a new emulsifier to replace ammonium perfluorooctanoate in fluoropolymer manufacturing. |
| PubMed:Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. |
| PubMed:Pathology Working Group review and evaluation of proliferative lesions of mammary gland tissues in female rats fed ammonium perfluorooctanoate (APFO) in the diet for 2 years. |
| PubMed:Male reproductive system parameters in a two-generation reproduction study of ammonium perfluorooctanoate in rats and human relevance. |
| PubMed:Role of peroxisome proliferator-activated receptor-alpha in hepatobiliary injury induced by ammonium perfluorooctanoate in mouse liver. |
| PubMed:Ammonium perfluorooctanoate substantially alters phenotype and cytokine secretion of human monocyte-derived dendritic cells in vitro. |
| PubMed:Ammonium perfluorooctanoate production and occupational mortality. |
| PubMed:Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha. |
| PubMed:Ischaemic heart disease mortality study among workers with occupational exposure to ammonium perfluorooctanoate. |
| PubMed:Estimation and validation of biomarker-based exposures for historical ammonium perfluorooctanoate. |
| PubMed:Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate. |
| PubMed:Acute and chronic aquatic toxicity of ammonium perfluorooctanoate (APFO) to freshwater organisms. |
| PubMed:Cross-sectional study of lipids and liver enzymes related to a serum biomarker of exposure (ammonium perfluorooctanoate or APFO) as part of a general health survey in a cohort of occupationally exposed workers. |
| PubMed:Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate. |
| PubMed:Partitioning and removal of perfluorooctanoate during rain events: the importance of physical-chemical properties. |
| PubMed:Partitioning of hydrogen peroxide between the gas and liquid phases in the presence of surfactant. |
| PubMed:Transport of ammonium perfluorooctanoate in environmental media near a fluoropolymer manufacturing facility. |
| PubMed:Analysis of perfluorocarboxylic acids in air. |
| PubMed:Influence of persistent contaminants and steroid hormones on glioblastoma cell growth. |
| PubMed:Ammonium perfluorooctanoate as a volatile surfactant for the analysis of N-methylcarbamates by MEKC-ESI-MS. |
| PubMed:Age effect on perfluorooctanoate (PFOA) plasma concentration in post-weaning rats following oral gavage with ammonium perfluorooctanoate (APFO). |
| PubMed:Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species. |
| PubMed:Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO). |
| PubMed:Method for the determination of perfluorooctanoic acid in air samples using liquid chromatography with mass spectrometry. |
| PubMed:Penetration of ammonium perfluorooctanoate through rat and human skin in vitro. |
| PubMed:13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male rats. |
| PubMed:Analytical techniques and method validation for the measurement of selected semivolatile and nonvolatile organofluorochemicals in air. |
| PubMed:Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys. |
| PubMed:Gas-phase NMR technique for studying the thermolysis of materials: thermal decomposition of ammonium perfluorooctanoate. |
| PubMed:The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat. |
| PubMed:Fluorinated ionic surfactant microemulsions in hydrofluorocarbon 134a (HFC 134a). |
| PubMed:Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months. |
| PubMed:PAH degradation by UV/H2O2 in perfluorinated surfactant solutions. |
| PubMed:Solubilization of polycyclic aromatic hydrocarbons by perfluorinated surfactant micelles. |
| PubMed:Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. |
| PubMed:Plasma cholecystokinin and hepatic enzymes, cholesterol and lipoproteins in ammonium perfluorooctanoate production workers. |
| PubMed:Mechanisms for the pancreatic oncogenic effects of the peroxisome proliferator Wyeth-14,643. |
| PubMed:Effect of the peroxisome proliferator, ammonium perfluorooctanoate (C8), on hepatic aromatase activity in adult male Crl:CD BR (CD) rats. |
| PubMed:The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro. |
| PubMed:Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies. |
| PubMed:The potential of fluorinated surfactants in membrane biochemistry. |
| PubMed:Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrine-related mechanism. |
| PubMed:Acute inhalation toxicity of ammonium perfluorononanoate. |
| PubMed:Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals. |
| PubMed:Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation. |
| PubMed:Inhalation toxicity of ammonium perfluorooctanoate. |
| PubMed:Dermal toxicity of ammonium perfluorooctanoate. |
| PubMed:The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat. |
| PubMed:Animal toxicity studies with ammonium perfluorooctanoate. |
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3D/inchi