EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

imidazolidinyl urea
urea, N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-

Supplier Sponsors

Name:1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea
CAS Number: 39236-46-9Picture of molecule3D/inchi
Other(deleted CASRN):82852-50-4
ECHA EINECS - REACH Pre-Reg:254-372-6
FDA UNII:M629807ATL
Nikkaji Web:J236.023C
Beilstein Number:8731946
MDL:MFCD00221482
XlogP3-AA:-3.40 (est)
Molecular Weight:388.29812000
Formula:C11 H16 N8 O8
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -4.930 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
BOC Sciences
For experimental / research use only.
Imidazolidinyl Urea ≥98%
Odor: characteristic
Use: Imidazolidinyl urea is an antimicrobial preservative acts as a formaldehyde releaser. An antimicrobial preservative used in cosmetics
Charkit Chemical
IMIDAZOLIDINYL UREA
Connect Chemicals
Imidazilydinyl urea (IMU)
Odor: characteristic
Use: Biocon IMU is a wide spectrum preservative, efficient against both gram positive and negative bacteria, including species of pseudomonas. Biocon IMU shows a synergic effect with parabens. Biocon IMU is used in a broad range of personal care fomulations.
ECSA Chemicals
IMIDAZOLIDINYL UREA
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Kingyoung Bio Technical
Imidazolidinyl Urea
Kraft Chemical
Imidzaolidinyl Urea USP/NF
Nanjing Jiancheng Chemical
Imidazolidinyl Urea(Germall 115)
Odor: characteristic
Use: Imidazolidinyl urea is widely used as antiseptic for its bactericidal effect. It can constrain the bacterium, yeast, mould, gram-positive bacterium and gram-negative bacterium. Imidazolidinyl urea can be applied in cream, dew liquid, shampoo, hair conditioner, eye cosmetics, liquid cosmetics and other cosmetics.
Santa Cruz Biotechnology
For experimental / research use only.
Imidazolidinyl Urea 98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Imidazolidinyl urea
TCI AMERICA
For experimental / research use only.
Imidazolidinyl Urea
TRI-K Industries
TRIstat IU (NF)
Odor: characteristic
Use: Safe, non-irritating and non sensitizing to the skin. Highly effective against Gram positive and Gram negative bacteria.
Universal Preserv-A-Chem Inc.
IMIDAZOLIDINYL UREA
Odor: characteristic
Use: Imidazolidinyl urea is an antimicrobial preservative used in cosmetics. It is chemically related to diazolidinyl urea which is used in the same way. Imidazolidinyl urea acts as a formaldehyde releaser.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 11300 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM
Journal of Environmental Pathology and Toxicology. Vol. 4(4), Pg. 133, 1980.

oral-mouse LD50 7200 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Environmental Pathology and Toxicology. Vol. 4(4), Pg. 133, 1980.

intraperitoneal-rat LDLo 4000 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM
Journal of Environmental Pathology and Toxicology. Vol. 4(4), Pg. 133, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for imidazolidinyl urea usage levels up to:
 not for fragrance use.
 
Recommendation for imidazolidinyl urea flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):39236-46-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :38258
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea
Chemidplus:0039236469
RTECS:YT7365000 for cas# 39236-46-9
 
References:
 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:39236-46-9
Pubchem (cid):38258
Pubchem (sid):135001474
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D04513
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2924.21.4500
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 abiol
 germall 115
 imidazolinidyl urea
 imidurea
1,1'-methanediylbis{3-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}
N,N''-methylene bis(N'-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)
1,1'-methylenebis(3-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
N,N"-methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)
N,N`-methylenebis[N`-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl] urea
N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
N,N"-methylenebis[N"-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea]
1,1'-methylenebis{3-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea}
1,1'-methylenebis{3-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}
N,N-methylenebisN'-1- -2,5-dioxo-4-imidazolidinylurea
 urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-
 urea, N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-
 

Articles:

PubMed:Contact sensitivity to preservatives in Singapore: frequency of sensitization to 11 common preservatives 2006-2011.
PubMed:Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives.
PubMed:Allantoin as a solid phase adsorbent for removing endotoxins.
PubMed:Characterization and removal of aggregates formed by nonspecific interaction of IgM monoclonal antibodies with chromatin catabolites during cell culture production.
PubMed:Frequency of positive patch test reactions to preservatives: The Australian experience.
PubMed:Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008.
PubMed:Simultaneous determination of eleven preservatives in cosmetics by micellar electrokinetic chromatography.
PubMed:Cell chip-based monitoring of toxic effects of cosmetic compounds on skin fibroblast cells.
PubMed:Formalehyde in personal care products.
PubMed:Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials.
PubMed:[Contact sensitization to allergens in the Spanish standard series at Hospital Costa del Sol in Marbella, Spain: a retrospective study (2005-2010)].
PubMed:Non-fragrance allergens in specific cosmetic products.
PubMed:Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009).
PubMed:Time trends of contact allergy to a modified European baseline series in Beijing between 2001 and 2006.
PubMed:Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008.
PubMed:Hydrogel allergic contact dermatitis and imidazolidinyl urea/diazolidinyl urea.
PubMed:Contact allergy to preservatives. Analysis of IVDK data 1996-2009.
PubMed:Allergic contact dermatitis in a girl due to several cosmetics containing diazolidinyl-urea or imidazolidinyl-urea.
PubMed:Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro.
PubMed:Positive concomitant test reactions to allergens in the standard patch test series.
PubMed:Formaldehyde-releasers in cosmetics in the USA and in Europe.
PubMed:Temporal trends of preservative allergy in Denmark (1985-2008).
PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde.
PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics.
PubMed:In vitro synergistic activities of essential oils and surfactants in combination with cosmetic preservatives against Pseudomonas aeruginosa and Staphylococcus aureus.
PubMed:Hand dermatitis: a focus on allergic contact dermatitis to biocides.
PubMed:Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II.
PubMed:Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema.
PubMed:Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group.
PubMed:Contact sensitivity to preservatives in the UK, 2004-2005: results of multicentre study.
PubMed:[Contact allergy to preservatives contained in cosmetics].
PubMed:The relationship of vehicle and concentration for imidazolidinylurea, with attention to formaldehyde allergy status.
PubMed:The relationship of vehicle and concentration of imidazolidinylurea, with attention to formaldehyde allergy status.
PubMed:Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea.
PubMed:Can an imidazolidinyl urea-preserved corticosteroid cream be safely used in individuals hypersensitive to formaldehyde?
PubMed:Cosmetic dermatitis in Chinese eczema patients patch tested with a modified European standard series of allergens.
PubMed:[Allergy to diazolidinyl urea (Germall II) and imidazolidinyl urea (Germall 115)].
PubMed:Contact sensitivity to preservatives in Turkey.
PubMed:Evaluation of phototoxic properties of antimicrobials used in topical preparations by a photohaemolysis test.
PubMed:[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
PubMed:The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance.
PubMed:In vitro induction of apoptosis vs. necrosis by widely used preservatives: 2-phenoxyethanol, a mixture of isothiazolinones, imidazolidinyl urea and 1,2-pentanediol.
PubMed:Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine. Part 1. Synthesis and pharmacological activity of chain derivatives of 1-aryl-2-iminoimidazolidine containing urea moiety.
PubMed:Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches.
PubMed:Comparison of patch test results with a standard series among white and black racial groups.
PubMed:Contact sensitization to corticosteroids: increased risk in long term dermatoses.
PubMed:Allergic contact dermatitis from imidazolidinyl urea in an ultrasonic gel.
PubMed:Concomitant positive reactions to allergens in a patch testing standard series from 1988-1997.
PubMed:Significance-prevalence index number: a reinterpretation and enhancement of data from the North American contact dermatitis group.
PubMed:Physician, heed thy shelf.
PubMed:Simultaneous HPLC determination of multiple components in a commercial cosmetic cream.
PubMed:Mechanisms of cytotoxicity by cosmetic ingredients in sea urchin eggs.
PubMed:A method for quantification of formaldehyde in the presence of formaldehyde donors in skin-care products.
PubMed:Flow-cytometric screening for the modulation of receptor-mediated endocytosis in human dendritic cells: implications for the development of an in vitro technique for predictive testing of contact sensitizers.
PubMed:Utilization of electrochemical silver ions as preservative agent in cosmetic dispersions.
PubMed:Comparison of automated and traditional minimum inhibitory concentration procedures for microbiological cosmetic preservatives.
PubMed:Reactions to formaldehyde and formaldehyde releasers in a standard series.
PubMed:Patch testing with preservatives at St John's from 1982 to 1993.
PubMed:Chloromethylisothiazolone/methylisothiazolone (CMI/MI) use test with a shampoo on patch-test-positive subjects. Results of a multicentre double-blind crossover trial.
PubMed:Cytotoxicity tests of antibacterial agents on human fibroblasts cultures.
PubMed:[Sensitization to hypoallergenic cosmetics].
PubMed:Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group.
PubMed:Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance.
PubMed:[Antimicrobial conservation of some cosmetics].
PubMed:Direct contact membrane inoculation of yeasts and moulds for evaluating preservative efficacy in solid cosmetics.
PubMed:Imidazolidinyl urea (Germall 115) should be patch tested in water.
PubMed:Direct contact membrane method for evaluating preservative efficacy in solid cosmetics.
PubMed:Water versus petrolatum for testing imidazolidinyl urea.
PubMed:Chemical stability and microbiological reply of preservative systems in cosmetics: a direct correlation.
PubMed:Dose-response sensitization experiments with imidazolidinyl urea.
PubMed:Contact allergy to diazolidinyl urea (Germall II).
PubMed:Dehydroacetic acid sodium salt stability in cosmetic preservative mixtures.
PubMed:Correlation of in vitro challenge testing with consumer use testing for cosmetic products.
PubMed:Hidden contact allergy to formaldehyde in imidazolidinyl urea.
PubMed:Imidazolidinyl urea (germall 115) causing cosmetic dermatitis.
PubMed:Experimental delayed contact sensitization to diazolidinyl urea (Germall II) in guinea pigs.
PubMed:Imidazolidinyl urea dermatitis.
PubMed:Reactions to Quaternium 15, Bronopol and Germall 115 in a standard series.
PubMed:A five-year study of cosmetic reactions.
PubMed:Guinea pig maximization tests with formaldehyde releasers. Results from two laboratories.
PubMed:Concentrated solutions of preservatives: their technological and analytical advantages in cosmetic products.
PubMed:[Allergy to preservatives].
PubMed:Iatrogenic dermatitis.
PubMed:Cosmetic ingredients and their safety assessment. Reports issued by the Cosmetic Ingredient Review.
PubMed:Cosmetic dermatitis. Part II. Reactions to some commonly used preservatives.
PubMed:Allergic contact dermatitis from Germall 115, a new cosmetic preservative.
PubMed:Letter: Contact dermatitis to substituted imidazolidinyl urea--a common preservative in cosmetics.
 
Notes:
None found
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